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Tbio
FOXA1
Hepatocyte nuclear factor 3-alpha

Protein Summary
Description
Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). Modulates the transcriptional activit ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000250448
  • ENSP00000250448
  • ENSG00000129514

Symbol
  • HNF3A
  • TCF3A
  • HNF3A
  • TCF3A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
PubMedID
0.99
gene perturbation
0.96
transcription factor binding site profile
0.84
biological term
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 484.63   (req: < 5)
Gene RIFs: 170   (req: <= 3)
Antibodies: 1361   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 484.63   (req: >= 5)
Gene RIFs: 170   (req: > 3)
Antibodies: 1361   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (243)
PLOD1
Tbio
Family:  Enzyme
Novelty:  0.00905345
p_int:  0.99999362
p_ni:  1.4e-8
p_wrong:  0.000006366
Score:  0.199
Data Source:  BioPlex,STRINGDB
AR
Tclin
Family:  NR
Novelty:  0.00013531
Score:  0.991
Data Source:  STRINGDB
ESR1
Tclin
Family:  NR
Novelty:  0.00005938
Score:  0.989
Data Source:  Reactome,STRINGDB
GATA3
Tbio
Family:  TF
Novelty:  0.00071141
Score:  0.988
Data Source:  Reactome,STRINGDB
EP300
Tchem
Family:  Epigenetic
Novelty:  0.00055009
Score:  0.973
Data Source:  Reactome,STRINGDB
TFF1
Tbio
Novelty:  0.00295014
Score:  0.97
Data Source:  STRINGDB
PGR
Tclin
Family:  NR
Novelty:  0.00008416
Score:  0.96
Data Source:  STRINGDB
FOS
Tbio
Family:  TF
Novelty:  0.00006103
Score:  0.96
Data Source:  STRINGDB
TLE3
Tbio
Novelty:  0.02641884
Score:  0.954
Data Source:  STRINGDB
TBP
Tbio
Novelty:  0.00034941
Score:  0.953
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
ESR-mediated signaling (R-HSA-8939211)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ESR-mediated signaling
Reactome
Estrogen-dependent gene expression
Reactome
Signal Transduction
Reactome
Signaling by Nuclear Receptors
Name
Explore in Pharos
Explore in Source
ESR-mediated signaling
Estrogen-dependent gene expression
Signal Transduction
Signaling by Nuclear Receptors
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (43)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
1
1
57.1
intraocular pressure measurement
1
2
2
52.4
1
1
0
1.1
28.1
tonsillectomy risk measurement
1
1
0
1.1
13.1
eosinophil count
1
1
1
7.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
57.1
intraocular pressure measurement
2
52.4
0
1.1
28.1
tonsillectomy risk measurement
0
1.1
13.1
eosinophil count
1
7.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
forkhead box A1
VGNC:12637
737693
Macaque
forkhead box A1
697909
Mouse
MGI:1347472
15375
Rat
RGD:2807
25098
Dog
forkhead box A1
VGNC:53490
490657
Species
Name
OMA
EggNOG
Inparanoid
Chimp
forkhead box A1
Macaque
forkhead box A1
Mouse
Rat
Dog
forkhead box A1
Publication Statistics
PubMed Score 484.63
PubMed score by year
PubTator Score 284.78
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title