Tbio FOXA1 Hepatocyte nuclear factor 3-alpha

Protein Summary

Description

Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription; required for ESR1 binding to the NKX2-1 promoter in breast cancer cells; binds to the RPRM promoter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis. This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P55317
• B2R9H6
• B7ZAP5
• Q9H2A0
• HNF-3-alpha

Gene Name

• FOXA1

Ensembl ID

• ENST00000250448
• ENSP00000250448
• ENSG00000129514

Symbol

• HNF3A
• TCF3A
• HNF3A
• TCF3A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.99
PubMedID	0.99
gene perturbation	0.96
transcription factor binding site profile	0.84
biological term	0.79

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Hepatocyte Nuclear Factor 3-alpha

Protein / Nucleic Acid Binding / Dna Binding Protein / Hepatocyte Nuclear Factor 3-alpha

Protein / ... / Winged Helix/forkhead Transcription Factor / Hepatocyte Nuclear Factor 3-alpha

DTO Classes

Protein / Transcription Factor / Helix-turn-helix Transcription Factor / Winged Helix/forkhead Transcription Factor / Hepatocyte Nuclear Factor 3-alpha

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 551.51   (req: < 5)

Gene RIFs: 290   (req: <= 3)

Antibodies: 1361   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 551.51   (req: >= 5)

Gene RIFs: 290   (req: > 3)

Antibodies: 1361   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0