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Tbio
FOXG1
Forkhead box protein G1

Protein Summary
Description
Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon. This locus encodes a member of the forked-head transcription factor family. The encoded protein, which functions as a repressor, may play a role in brain development. Mutations at this locus have been associated with Rett syndrome. [provided by RefSeq, Feb 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313071
  • ENSP00000339004
  • ENSG00000176165

Symbol
  • FKH2
  • FKHL1
  • FKHL2
  • FKHL3
  • FKHL4
  • FOXG1A
  • FOXG1B
  • FOXG1C
  • BF1
  • BF2
  • QIN
  • FKH2
  • HBF2
  • HFK1
  • HFK2
  • HFK3
  • KHL2
  • FHKL3
  • FKHL1
  • FKHL2
  • FKHL3
  • FKHL4
  • HBF-1
  • HBF-2
  • HBF-3
  • FOXG1A
  • FOXG1B
  • FOXG1C
  • HBF-G2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.95
disease perturbation
0.79
PubMedID
0.76
hub protein
0.71
small molecule perturbation
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 696.3   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 265   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 696.3   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 265   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (202)
1 – 10 of 202
PROZ
Tbio
Family:  Enzyme
Novelty:  0.05629679
p_int:  0.999986424
p_ni:  0.000013566
p_wrong:  1e-8
Score:  0.187
Data Source:  BioPlex,STRINGDB
THSD4
Tbio
Novelty:  0.12898073
p_int:  0.934027111
p_ni:  0.0000929
p_wrong:  0.065879989
Score:  0.204
Data Source:  BioPlex,STRINGDB
FOXO1
Tbio
Family:  TF
Novelty:  0.00058938
Score:  0.957
Data Source:  STRINGDB
FOXO3
Tbio
Family:  TF
Novelty:  0.00074316
Score:  0.952
Data Source:  Reactome,STRINGDB
FOXO4
Tbio
Family:  TF
Novelty:  0.00544293
Score:  0.951
Data Source:  STRINGDB
SMAD3
Tchem
Family:  TF
Novelty:  0.00048058
Score:  0.946
Data Source:  Reactome,STRINGDB
SMAD2
Tbio
Family:  TF
Novelty:  0.00040166
Score:  0.945
Data Source:  Reactome,STRINGDB
SMAD4
Tbio
Family:  TF
Novelty:  0.00047069
Score:  0.944
Data Source:  Reactome,STRINGDB
SRF
Tbio
Family:  TF
Novelty:  0.00088839
Score:  0.883
Data Source:  STRINGDB
AKT1
Tchem
Family:  Kinase
Novelty:  0.00003185
Score:  0.865
Data Source:  STRINGDB
Pathways (18)
FOXO-mediated transcription (R-HSA-9614085)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
FOXO-mediated transcription
Reactome
FOXO-mediated transcription of cell cycle genes
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
FOXO-mediated transcription
FOXO-mediated transcription of cell cycle genes
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
daytime rest measurement
1
1
1
65.6
mathematical ability
3
2
3
60.8
smoking status measurement
1
1
1
38.8
cortical surface area measurement
1
1
0
6.7
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
daytime rest measurement
1
65.6
mathematical ability
3
60.8
smoking status measurement
1
38.8
cortical surface area measurement
0
6.7
31.4
Find similar targets by:
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
forkhead box G1
467416
Macaque
forkhead box G1
716287
Mouse
MGI:1347464
15228
Rat
RGD:2619
24370
Opossum
forkhead box G1
100013551
Species
Name
OMA
EggNOG
Inparanoid
Chimp
forkhead box G1
Macaque
forkhead box G1
Mouse
Rat
Opossum
forkhead box G1
Publication Statistics
PubMed Score 696.30
PubMed score by year
PubTator Score 632.80
PubTator score by year