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Tbio
CDH15
Cadherin-15

Protein Summary
Description
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation. This gene is a member of the cadherin superfamily of genes, encoding calcium-dependent intercellular adhesion glycoproteins. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from this particular cadherin are expressed in myoblasts and upregulated in myotubule-forming cells. The protein is thought to be essential for the control of morphogenetic processes, specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000289746
  • ENSP00000289746
  • ENSG00000129910

Symbol
  • CDH14
  • CDH3
  • CDH3
  • CDHM
  • MCAD
  • MRD3
  • CDH14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
transcription factor
0.59
cell type or tissue
0.56
cell line
0.46
gene perturbation
0.46


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.85   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 296   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.85   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 296   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.4
68.1
1
1
0
1.4
44.5
non-melanoma skin carcinoma
1
1
0
1.3
30.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.4
68.1
0
1.4
44.5
non-melanoma skin carcinoma
0
1.3
30.4
Pathways (45)
Adherens junctions interactions (R-HSA-418990)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adherens junctions interactions
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Reactome
Developmental Biology
Name
Explore in Pharos
Explore in Source
Adherens junctions interactions
Cell junction organization
Cell-Cell communication
Cell-cell junction organization
Developmental Biology
Gene Ontology Terms (22)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (65)
1 – 10 of 65
CTNNB1
Tchem
Novelty: 0.0000744
Score: 0.964
Data Source: Reactome,STRINGDB
CTNNA1
Tbio
Novelty: 0.00925774
Score: 0.959
Data Source: Reactome,STRINGDB
JUP
Tbio
Novelty: 0.0081803
Score: 0.957
Data Source: STRINGDB
CDH9
Tbio
Novelty: 0.06379235
Score: 0.94
Data Source: STRINGDB
CDH7
Tbio
Novelty: 0.03451354
Score: 0.939
Data Source: STRINGDB
CTNND1
Tbio
Novelty: 0.00335459
Score: 0.938
Data Source: STRINGDB
CDON
Tbio
Novelty: 0.00447262
Score: 0.932
Data Source: Reactome,STRINGDB
CDH17
Tbio
Novelty: 0.00035679
Score: 0.924
Data Source: STRINGDB
CDH8
Tbio
Novelty: 0.04055999
Score: 0.916
Data Source: STRINGDB
CDH5
Tbio
Novelty: 0.00072649
Score: 0.916
Data Source: STRINGDB
Publication Statistics
PubMed Score  47.85

PubMed score by year
PubTator Score  43.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer