Tbio CDH13 Cadherin-13

Protein Summary

Description

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth. This gene encodes a member of the cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. The protein lacks the cytoplasmic domain characteristic of other cadherins, and so is not thought to be a cell-cell adhesion glycoprotein. This protein acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. The gene is hypermethylated in many types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2011]

Uniprot Accession IDs

• P55290
• A8W476
• A8W477
• B7Z590
• C9JRI6
• J3KN62
• Q6GTW4
• Q8TBX3

Gene Name

• CDH13

Ensembl ID

• ENST00000268613
• ENSP00000268613
• ENSG00000140945
• ENST00000428848
• ENSP00000394557
• ENST00000431540
• ENSP00000408632
• ENST00000565636
• ENSP00000456491
• ENST00000567109
• ENSP00000479395

Symbol

• CDHH
• CDHH
• P105

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	1
PubMedID	0.94
disease	0.9
biological process	0.87
phenotype	0.77

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 316.47   (req: < 5)

Gene RIFs: 151   (req: <= 3)

Antibodies: 586   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 316.47   (req: >= 5)

Gene RIFs: 151   (req: > 3)

Antibodies: 586   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0