Protein Summary
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth. This gene encodes a member of the cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. The protein lacks the cytoplasmic domain characteristic of other cadherins, and so is not thought to be a cell-cell adhesion glycoprotein. This protein acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. The gene is hypermethylated in many types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, ...more
- ENST00000268613
- ENSP00000268613
- ENSG00000140945
- ENST00000428848
- ENSP00000394557
- ENST00000431540
- ENSP00000408632
- ENST00000565636
- ENSP00000456491
- ENST00000567109
- ENSP00000479395
- CDHH
- CDHH
- P105
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
trait | 1 | ||
PubMedID | 0.94 | ||
disease | 0.9 | ||
biological process | 0.87 | ||
phenotype | 0.77 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 285.63 (req: < 5)
Gene RIFs: 126 (req: <= 3)
Antibodies: 586 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 285.63 (req: >= 5)
Gene RIFs: 126 (req: > 3)
Antibodies: 586 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 33
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (94)
SEC14L1
Novelty: 0.09562071
p_int: 0.99999869
p_ni: 0.00000131
Score: 0.169
Data Source: BioPlex,STRINGDB
AGPAT5
Family: Enzyme
Novelty: 0.23785857
p_int: 0.999852081
p_ni: 0.000147748
p_wrong: 1.72e-7
Score: 0.189
Data Source: BioPlex,STRINGDB
INSIG1
Novelty: 0.00999942
p_int: 0.991377276
p_ni: 3.1e-8
p_wrong: 0.008622693
Score: 0.277
Data Source: BioPlex,STRINGDB
DSTYK
Family: Kinase
Novelty: 0.12049855
p_int: 0.981378687
p_ni: 0.018621313
Score: 0.151
Data Source: BioPlex,STRINGDB
RRAGB
Novelty: 0.02279777
p_int: 0.968779466
p_ni: 0.028430643
p_wrong: 0.002789892
Score: 0.248
Data Source: BioPlex,STRINGDB
ERMP1
Family: Enzyme
Novelty: 0.16736317
p_int: 0.968107069
p_ni: 0.031892931
Data Source: BioPlex
DNAAF2
Novelty: 0.01254416
p_int: 0.938324311
p_ni: 0.061675663
p_wrong: 2.6e-8
Data Source: BioPlex
VMP1
Novelty: 0.00997613
p_int: 0.902940937
p_ni: 0.097059063
Score: 0.248
Data Source: BioPlex,STRINGDB
UQCC1
Family: Enzyme
Novelty: 0.03937066
p_int: 0.899296799
p_ni: 0.100703201
Data Source: BioPlex
Nearest Tclin Targets
Pathways (9)
Reactome (4)
PathwayCommons (2)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Adherens junctions interactions | ||||
Reactome | Cell junction organization | ||||
Reactome | Cell-Cell communication | ||||
Reactome | Cell-cell junction organization | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Adherens junctions interactions | ||||
Cell junction organization | ||||
Cell-Cell communication | ||||
Cell-cell junction organization | ||||
Viral Interactions (0)
Gene Ontology Terms (49)
Functions (7)
Components (16)
Processes (26)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Disease Associations ()
GWAS Traits (23)
Items per page:
1 – 5 of 23
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
adiponectin measurement | 7 | 4 | 7 | 97.9 | |||||
BMI-adjusted adiponectin measurement | 1 | 2 | 2 | 94.1 | |||||
mathematical ability | 4 | 8 | 10 | 80.6 | |||||
self reported educational attainment | 2 | 3 | 3 | 80.4 | |||||
adolescent idiopathic scoliosis | 2 | 2 | 0 | 1.2 | 76.2 | ||||
Items per page:
1 – 5 of 23
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
adiponectin measurement | 7 | 97.9 | |||||
BMI-adjusted adiponectin measurement | 2 | 94.1 | |||||
mathematical ability | 10 | 80.6 | |||||
self reported educational attainment | 3 | 80.4 | |||||
adolescent idiopathic scoliosis | 0 | 1.2 | 76.2 | ||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Macaque | cadherin 13 | 718038 | ||||||
Mouse | MGI:99551 | 12554 | ||||||
Rat | RGD:619745 | 192248 | ||||||
Dog | cadherin 13 | VGNC:39022 | 489689 | |||||
Horse | cadherin 13 | VGNC:16319 | 100055760 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Macaque | cadherin 13 | |||||
Mouse | ||||||
Rat | ||||||
Dog | cadherin 13 | |||||
Horse | cadherin 13 | |||||
Publication Statistics
PubMed Score 285.63
PubMed score by year
PubTator Score 212.16
PubTator score by year
Related Publications
Text Mined References (189)
GeneRif Annotations (126)
Items per page:
0 of 0
PMID | Year | Title |
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