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Tbio
CDH13
Cadherin-13

Protein Summary
Description
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth. This gene encodes a member of the cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. The protein lacks the cytoplasmic domain characteristic of other cadherins, and so is not thought to be a cell-cell adhesion glycoprotein. This protein acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. The gene is hypermethylated in many types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268613
  • ENSP00000268613
  • ENSG00000140945
  • ENST00000428848
  • ENSP00000394557
  • ENST00000431540
  • ENSP00000408632
  • ENST00000565636
  • ENSP00000456491
  • ENST00000567109
  • ENSP00000479395

Symbol
  • CDHH
  • CDHH
  • P105
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
PubMedID
0.94
disease
0.9
biological process
0.87
phenotype
0.77


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
View Data
 GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 281.81   (req: < 5)
View Publications
Gene RIFs: 126   (req: <= 3)
View Gene RIFs
Antibodies: 586   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 281.81   (req: >= 5)
Gene RIFs: 126   (req: > 3)
Antibodies: 586   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (18)
Items per page:
1 – 5 of 18
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
adiponectin measurement
EFO_0004502
4
2
4
99.5
BMI-adjusted adiponectin measurement
EFO_0007737
1
2
2
97.5
mathematical ability
EFO_0004875
4
8
10
95.5
self reported educational attainment
EFO_0004784
1
2
2
93.4
cognitive function measurement
EFO_0008354
1
2
2
85.1
Items per page:
1 – 5 of 18
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
adiponectin measurement
EFO_0004502
4
99.5
BMI-adjusted adiponectin measurement
EFO_0007737
2
97.5
mathematical ability
EFO_0004875
10
95.5
self reported educational attainment
EFO_0004784
2
93.4
cognitive function measurement
EFO_0008354
2
85.1
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
cadherin 13
718038
Mouse
cadherin 13
MGI:99551
12554
Rat
cadherin 13
RGD:619745
192248
Dog
cadherin 13
VGNC:39022
489689
Horse
cadherin 13
VGNC:16319
100055760
Species
Name
OMA
EggNOG
Inparanoid
Macaque
cadherin 13
Mouse
cadherin 13
Rat
cadherin 13
Dog
cadherin 13
Horse
cadherin 13
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (9)
Adherens junctions interactions (R-HSA-418990)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adherens junctions interactions
31 targets
R-HSA-418990
Reactome
Cell junction organization
88 targets
R-HSA-446728
Reactome
Cell-Cell communication
121 targets
R-HSA-1500931
Reactome
Cell-cell junction organization
63 targets
R-HSA-421270
Name
Explore in Pharos
Explore in Source
Adherens junctions interactions
31 targets
R-HSA-418990
Cell junction organization
88 targets
R-HSA-446728
Cell-Cell communication
121 targets
R-HSA-1500931
Cell-cell junction organization
63 targets
R-HSA-421270
Gene Ontology Terms (49)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
cadherin binding
Inferred from Direct Assay (IDA)
BHF-UCL
lipoprotein particle binding
Inferred from Direct Assay (IDA)
UniProtKB
low-density lipoprotein particle binding
Inferred from Direct Assay (IDA)
BHF-UCL
calcium ion binding
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
cytoskeletal protein binding
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
protein homodimerization activity
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
adiponectin binding
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Protein-Protein Interactions (94)
1 – 10 of 94
SEC14L1
Tbio
Novelty: 0.09562071
p_int: 0.99999869
p_ni: 0.00000131
Score: 0.169
Data Source: BioPlex,STRINGDB
AGPAT5
Tbio
Family: Enzyme
Novelty: 0.23785857
p_int: 0.999852081
p_ni: 0.000147748
p_wrong: 1.72e-7
Score: 0.189
Data Source: BioPlex,STRINGDB
INSIG1
Tbio
Novelty: 0.00999942
p_int: 0.991377276
p_ni: 3.1e-8
p_wrong: 0.008622693
Score: 0.277
Data Source: BioPlex,STRINGDB
DSTYK
Tchem
Family: Kinase
Novelty: 0.12049855
p_int: 0.981378687
p_ni: 0.018621313
Score: 0.151
Data Source: BioPlex,STRINGDB
RRAGB
Tbio
Novelty: 0.02279777
p_int: 0.968779466
p_ni: 0.028430643
p_wrong: 0.002789892
Score: 0.248
Data Source: BioPlex,STRINGDB
ERMP1
Tbio
Family: Enzyme
Novelty: 0.16736317
p_int: 0.968107069
p_ni: 0.031892931
Data Source: BioPlex
DNAAF2
Tbio
Novelty: 0.01254416
p_int: 0.938324311
p_ni: 0.061675663
p_wrong: 2.6e-8
Data Source: BioPlex
VMP1
Tbio
Novelty: 0.00997613
p_int: 0.902940937
p_ni: 0.097059063
Score: 0.248
Data Source: BioPlex,STRINGDB
UQCC1
Tbio
Family: Enzyme
Novelty: 0.03937066
p_int: 0.899296799
p_ni: 0.100703201
Data Source: BioPlex
TUBB3
Tclin
Novelty: 0.00195963
p_int: 0.895263365
p_ni: 0.104736635
Data Source: BioPlex
Publication Statistics
PubMed Score  281.81

PubMed score by year
PubTator Score  212.16

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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