Tbio CDH13 Cadherin-13

Protein Summary

Description

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth. This gene encodes a member of the cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. The protein lacks the cytoplasmic domain characteristic of other cadherins, and so is not thought to be a cell-cell adhesion glycoprotein. This protein acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. The gene is hypermethylated in many types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2011]

Uniprot Accession IDs

• P55290
• A8W476
• A8W477
• B7Z590
• C9JRI6
• J3KN62
• Q6GTW4
• Q8TBX3

Gene Name

• CDH13

Ensembl ID

• ENST00000268613
• ENSP00000268613
• ENSG00000140945
• ENST00000428848
• ENSP00000394557
• ENST00000431540
• ENSP00000408632
• ENST00000565636
• ENSP00000456491
• ENST00000567109
• ENSP00000479395

Symbol

• CDHH
• CDHH
• P105

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	1
PubMedID	0.94
disease	0.9
biological process	0.87
phenotype	0.77

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 285.63   (req: < 5)

Gene RIFs: 126   (req: <= 3)

Antibodies: 586   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 285.63   (req: >= 5)

Gene RIFs: 126   (req: > 3)

Antibodies: 586   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (94)

Explore Interacting Targets

1 – 10 of 94

• See Interactions on String-DB

SEC14L1

Tbio

Novelty:  0.09562071

p_int:  0.99999869

p_ni:  0.00000131

Score:  0.169

Data Source:  BioPlex,STRINGDB

AGPAT5

Tbio

Family:  Enzyme

Novelty:  0.23785857

p_int:  0.999852081

p_ni:  0.000147748

p_wrong:  1.72e-7

Score:  0.189

Data Source:  BioPlex,STRINGDB

INSIG1

Tbio

Novelty:  0.00999942

p_int:  0.991377276

p_ni:  3.1e-8

p_wrong:  0.008622693

Score:  0.277

Data Source:  BioPlex,STRINGDB

DSTYK

Tchem

Family:  Kinase

Novelty:  0.12049855

p_int:  0.981378687

p_ni:  0.018621313

Score:  0.151

Data Source:  BioPlex,STRINGDB

RRAGB

Tbio

Novelty:  0.02279777

p_int:  0.968779466

p_ni:  0.028430643

p_wrong:  0.002789892

Score:  0.248

Data Source:  BioPlex,STRINGDB

ERMP1

Tbio

Family:  Enzyme

Novelty:  0.16736317

p_int:  0.968107069

p_ni:  0.031892931

Data Source:  BioPlex

DNAAF2

Tbio

Novelty:  0.01254416

p_int:  0.938324311

p_ni:  0.061675663

p_wrong:  2.6e-8

Data Source:  BioPlex

VMP1

Tbio

Novelty:  0.00997613

p_int:  0.902940937

p_ni:  0.097059063

Score:  0.248

Data Source:  BioPlex,STRINGDB

UQCC1

Tbio

Family:  Enzyme

Novelty:  0.03937066

p_int:  0.899296799

p_ni:  0.100703201

Data Source:  BioPlex

TUBB3

Tclin

Novelty:  0.00195963

p_int:  0.895263365

p_ni:  0.104736635

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (9)

Reactome (4)

PathwayCommons (2)

WikiPathways (3)

Adherens junctions interactions (R-HSA-418990)

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Find Similar Targets

Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adherens junctions interactions	31 targets	R-HSA-418990
Reactome	Cell junction organization	88 targets	R-HSA-446728
Reactome	Cell-Cell communication	121 targets	R-HSA-1500931
Reactome	Cell-cell junction organization	63 targets	R-HSA-421270

Name	Explore in Pharos	Explore in Source
Adherens junctions interactions	31 targets	R-HSA-418990
Cell junction organization	88 targets	R-HSA-446728
Cell-Cell communication	121 targets	R-HSA-1500931
Cell-cell junction organization	63 targets	R-HSA-421270

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (49)

Functions (7)

Components (16)

Processes (26)

Find Similar Targets

Items per page:

10

1 – 7 of 7

GO Term	Evidence	Assigned by
cadherin binding	Inferred from Direct Assay (IDA)	BHF-UCL
lipoprotein particle binding	Inferred from Direct Assay (IDA)	UniProtKB
low-density lipoprotein particle binding	Inferred from Direct Assay (IDA)	BHF-UCL
calcium ion binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
cytoskeletal protein binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
protein homodimerization activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
adiponectin binding	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL

Disease Associations ()

No disease associations found

GWAS Traits (23)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 23

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
adiponectin measurement	EFO_0004502	7	4	7		97.9
BMI-adjusted adiponectin measurement	EFO_0007737	1	2	2		94.1
mathematical ability	EFO_0004875	4	8	10		80.6
self reported educational attainment	EFO_0004784	2	3	3		80.4
adolescent idiopathic scoliosis	EFO_0005423	2	2	0	1.2	76.2

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 23

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
adiponectin measurement	EFO_0004502	7		97.9
BMI-adjusted adiponectin measurement	EFO_0007737	2		94.1
mathematical ability	EFO_0004875	10		80.6
self reported educational attainment	EFO_0004784	3		80.4
adolescent idiopathic scoliosis	EFO_0005423	0	1.2	76.2

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Calcium
Cell adhesion
Cell membrane
Cleavage on pair of basic residues
Complete proteome
Direct protein sequencing
Glycoprotein
GPI-anchor

GWAS Trait Find Similar Targets

No Header	No Header
adiponectin measurement
adolescent idiopathic scoliosis
alcohol consumption measurement
biological sex
BMI-adjusted adiponectin measurement
body height
body mass index
cognitive function measurement
coronary artery disease
Crohn's disease

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
homeostasis/metabolism phenotype
vision/eye phenotype

IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	cadherin 13		718038
Mouse	cadherin 13	MGI:99551	12554
Rat	cadherin 13	RGD:619745	192248
Dog	cadherin 13	VGNC:39022	489689
Horse	cadherin 13	VGNC:16319	100055760

Species	Name	OMA	EggNOG	Inparanoid
Macaque	cadherin 13
Mouse	cadherin 13
Rat	cadherin 13
Dog	cadherin 13
Horse	cadherin 13

Publication Statistics

PubMed Score 285.63

PubMed score by year

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PubTator Score 212.16

PubTator score by year

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Related Publications

Text Mined References (189)

GeneRif Annotations (126)

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10

0 of 0

PMID	Year	Title