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Tbio
CDH11
Cadherin-11

Protein Summary
Description
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268603
  • ENSP00000268603
  • ENSG00000140937
  • ENST00000394156
  • ENSP00000377711

Symbol
  • OB
  • ESWS
  • CAD11
  • CDHOB
  • OSF-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
1
gene perturbation
0.92
transcription factor perturbation
0.88
disease
0.79
phenotype
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 242.57   (req: < 5)
Gene RIFs: 52   (req: <= 3)
Antibodies: 779   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 242.57   (req: >= 5)
Gene RIFs: 52   (req: > 3)
Antibodies: 779   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
4
4
5
92.5
cortical surface area measurement
1
1
0
20.4
57.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
5
92.5
cortical surface area measurement
0
20.4
57.1
Pathways (20)
Adherens junctions interactions (R-HSA-418990)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adherens junctions interactions
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Name
Explore in Pharos
Explore in Source
Adherens junctions interactions
Cell junction organization
Cell-Cell communication
Cell-cell junction organization
Gene Ontology Terms (24)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (83)
1 – 10 of 83
CTNNB1
Tchem
Novelty: 0.0000744
Score: 0.968
Data Source: STRINGDB
CTNND1
Tbio
Novelty: 0.00335459
Score: 0.953
Data Source: STRINGDB
CDH2
Tbio
Novelty: 0.00040112
Score: 0.942
Data Source: STRINGDB
JUP
Tbio
Novelty: 0.0081803
Score: 0.932
Data Source: STRINGDB
CTNNA1
Tbio
Novelty: 0.00925774
Score: 0.927
Data Source: STRINGDB
CDH17
Tbio
Novelty: 0.00035679
Score: 0.926
Data Source: STRINGDB
CDH13
Tbio
Novelty: 0.00389516
Score: 0.923
Data Source: STRINGDB
CDH3
Tbio
Novelty: 0.00295114
Score: 0.916
Data Source: STRINGDB
CDH15
Tbio
Novelty: 0.01904376
Score: 0.914
Data Source: STRINGDB
CDH1
Tbio
Novelty: 0.00010629
Score: 0.913
Data Source: STRINGDB
Publication Statistics
PubMed Score  242.57

PubMed score by year
PubTator Score  134.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer