Tbio CDH6 Cadherin-6

Protein Summary

Description

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This gene encodes a member of the cadherin superfamily. Cadherins are membrane glycoproteins that mediate homophilic cell-cell adhesion and play critical roles in cell differentiation and morphogenesis. The encoded protein is a type II cadherin and may play a role in kidney development as well as endometrium and placenta formation. Decreased expression of this gene may be associated with tumor growth and metastasis. [provided by RefSeq, May 2011]

Uniprot Accession IDs

• P55285
• A8K5H5
• Q9BWS0

Gene Name

• CDH6

Ensembl ID

• ENST00000265071
• ENSP00000265071
• ENSG00000113361

Symbol

• CAD6
• KCAD

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.81
cell type or tissue	0.79
gene perturbation	0.74
protein domain	0.73
kinase perturbation	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.36   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 386   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.36   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 386   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0