Tbio CDKN2D Cyclin-dependent kinase 4 inhibitor D

Protein Summary

Description

Interacts strongly with CDK4 and CDK6 and inhibits them. The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P55273
• Q13102
• Q6FGE9

Gene Name

• CDKN2D

Ensembl ID

• ENST00000335766
• ENSP00000337056
• ENSG00000129355
• ENST00000393599
• ENSP00000377224

Symbol

• p19
• INK4D
• p19-INK4D

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.93
virus perturbation	0.83
transcription factor binding site profile	0.74
small molecule perturbation	0.71
transcription factor	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.43   (req: < 5)

Gene RIFs: 32   (req: <= 3)

Antibodies: 271   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.43   (req: >= 5)

Gene RIFs: 32   (req: > 3)

Antibodies: 271   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0