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Tbio
LAMB2
Laminin subunit beta-2

Protein Summary
Description
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305544
  • ENSP00000307156
  • ENSG00000172037
  • ENST00000418109
  • ENSP00000388325

Symbol
  • LAMS
  • LAMS
  • NPHS5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
histone modification site profile
0.82
interacting protein
0.67
virus
0.66
tissue sample
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.71   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 359   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.71   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 359   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mood instability measurement
1
1
0
5.9
20.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mood instability measurement
0
5.9
20.8
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
laminin subunit beta 2
VGNC:6355
460365
Macaque
laminin subunit beta 2
707892
Mouse
MGI:99916
16779
Rat
RGD:2988
25473
Dog
laminin subunit beta 2
VGNC:42568
476626
Species
Name
OMA
EggNOG
Inparanoid
Chimp
laminin subunit beta 2
Macaque
laminin subunit beta 2
Mouse
Rat
Dog
laminin subunit beta 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P55268-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (34)
ECM proteoglycans (R-HSA-3000178)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ECM proteoglycans
Reactome
Extracellular matrix organization
Reactome
Laminin interactions
Reactome
MET activates PTK2 signaling
Reactome
MET promotes cell motility
Name
Explore in Pharos
Explore in Source
ECM proteoglycans
Extracellular matrix organization
Laminin interactions
MET activates PTK2 signaling
MET promotes cell motility
Protein-Protein Interactions (217)
1 – 10 of 217
DEFA1
Tbio
Novelty: 0.01027492
p_int: 0.978687991
p_ni: 0.021312009
Data Source: BioPlex
LYZL2
Tdark
Family: Enzyme
Novelty: 0.50542161
p_int: 0.965642463
p_ni: 0.034357537
Data Source: BioPlex
PLAUR
Tchem
Family: Enzyme
Novelty: 0.00087642
p_int: 0.961922975
p_ni: 0.038077025
Data Source: BioPlex
DNAJC10
Tbio
Novelty: 0.02258366
p_int: 0.957191373
p_ni: 0.042808627
Score: 0.188
Data Source: BioPlex,STRINGDB
TMEM25
Tdark
Novelty: 0.35505784
p_int: 0.954227078
p_ni: 0.045772922
Data Source: BioPlex
GML
Tdark
Novelty: 0.04982168
p_int: 0.941151601
p_ni: 0.058848399
Data Source: BioPlex
SIAE
Tbio
Family: Enzyme
Novelty: 0.01138067
p_int: 0.929837646
p_ni: 0.070162354
Score: 0.205
Data Source: BioPlex,STRINGDB
SLAMF1
Tbio
Novelty: 0.00112892
p_int: 0.927629458
p_ni: 0.072370542
Data Source: BioPlex
ADAM18
Tdark
Family: Enzyme
Novelty: 0.22622379
p_int: 0.915437162
p_ni: 0.084562838
Data Source: BioPlex
NELL1
Tbio
Family: Enzyme
Novelty: 0.01325888
p_int: 0.903354399
p_ni: 0.096645601
Data Source: BioPlex
Publication Statistics
PubMed Score  12.71

PubMed score by year
PubTator Score  53.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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