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Tbio
ADAR
Double-stranded RNA-specific adenosine deaminase

Protein Summary
Description
Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing (PubMed:7972084, PubMed:7565688, PubMed:12618436). This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368471
  • ENSP00000357456
  • ENSG00000160710
  • ENST00000368474
  • ENSP00000357459
  • ENST00000529168
  • ENSP00000431794
  • ENST00000647597
  • ENSP00000497276
  • ENST00000648231
  • ENSP00000497555
  • ENST00000648311
  • ENSP00000498137
  • ENST00000649042
  • ENSP00000497790
  • ENST00000649593
  • ENSP00000497589
  • ENST00000649724
  • ENSP00000497932
  • ENST00000649749
  • ENSP00000497210

Symbol
  • ADAR1
  • DSRAD
  • G1P1
  • IFI4
  • DSH
  • AGS6
  • G1P1
  • IFI4
  • P136
  • ADAR1
  • DRADA
  • DSRAD
  • IFI-4
  • K88DSRBP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
virus perturbation
1
biological process
0.96
transcription factor binding site profile
0.91
biological term
0.82


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1061.75   (req: < 5)
Gene RIFs: 279   (req: <= 3)
Antibodies: 249   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1061.75   (req: >= 5)
Gene RIFs: 279   (req: > 3)
Antibodies: 249   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0