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Tbio
ADAR
Double-stranded RNA-specific adenosine deaminase

Protein Classes
Protein Summary
Description
Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing (PubMed:7972084, PubMed:7565688, PubMed:12618436). This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368471
  • ENSP00000357456
  • ENSG00000160710
  • ENST00000368474
  • ENSP00000357459
  • ENST00000529168
  • ENSP00000431794
  • ENST00000647597
  • ENSP00000497276
  • ENST00000648231
  • ENSP00000497555
  • ENST00000648311
  • ENSP00000498137
  • ENST00000649042
  • ENSP00000497790
  • ENST00000649593
  • ENSP00000497589
  • ENST00000649724
  • ENSP00000497932
  • ENST00000649749
  • ENSP00000497210

Symbol
  • ADAR1
  • DSRAD
  • G1P1
  • IFI4
  • DSH
  • AGS6
  • G1P1
  • IFI4
  • P136
  • ADAR1
  • DRADA
  • DSRAD
  • IFI-4
  • K88DSRBP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
virus perturbation
1
biological process
0.96
transcription factor binding site profile
0.91
biological term
0.82


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 863.5   (req: < 5)
Gene RIFs: 181   (req: <= 3)
Antibodies: 249   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 863.5   (req: >= 5)
Gene RIFs: 181   (req: > 3)
Antibodies: 249   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
3
6
99.4
vitamin D measurement
2
2
2
75.5
testosterone measurement
1
1
1
63.4
smoking status measurement
1
1
1
59.5
apolipoprotein A 1 measurement
1
1
1
49.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
99.4
vitamin D measurement
2
75.5
testosterone measurement
1
63.4
smoking status measurement
1
59.5
apolipoprotein A 1 measurement
1
49.3
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adenosine deaminase, RNA specific
VGNC:27
457349
Macaque
adenosine deaminase, RNA specific
718759
Mouse
MGI:1889575
56417
Rat
RGD:71099
81635
Dog
adenosine deaminase, RNA specific
VGNC:37612
100855668
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adenosine deaminase, RNA specific
Macaque
adenosine deaminase, RNA specific
Mouse
Rat
Dog
adenosine deaminase, RNA specific
Protein Structure (15 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P55265-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 15
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (46)
C6 deamination of adenosine (R-HSA-75102)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
C6 deamination of adenosine
Reactome
Cytokine Signaling in Immune system
Reactome
Formation of editosomes by ADAR proteins
Reactome
Immune System
Reactome
Interferon Signaling
Name
Explore in Pharos
Explore in Source
C6 deamination of adenosine
Cytokine Signaling in Immune system
Formation of editosomes by ADAR proteins
Immune System
Interferon Signaling
Gene Ontology Terms (27)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (231)
1 – 10 of 231
LY86
Tbio
Novelty: 0.00314575
p_int: 0.950190499
p_ni: 0.049809502
Data Source: BioPlex
USP38
Tbio
Family: Enzyme
Novelty: 0.10350208
p_int: 0.947782036
p_ni: 0.052217964
Score: 0.68
Data Source: BioPlex,STRINGDB
SAMHD1
Tbio
Family: Enzyme
Novelty: 0.00294595
Score: 0.966
Data Source: STRINGDB
UPF1
Tbio
Novelty: 0.00311006
Score: 0.962
Data Source: STRINGDB
IRF7
Tbio
Family: TF
Novelty: 0.0021839
Score: 0.962
Data Source: STRINGDB
STAT2
Tbio
Family: TF
Novelty: 0.00241454
Score: 0.961
Data Source: STRINGDB
MX1
Tbio
Novelty: 0.00072554
Score: 0.96
Data Source: STRINGDB
ISG15
Tbio
Novelty: 0.00203781
Score: 0.958
Data Source: STRINGDB
RNASEL
Tchem
Family: Kinase
Novelty: 0.00165549
Score: 0.953
Data Source: STRINGDB
IRF9
Tbio
Family: TF
Novelty: 0.00751233
Score: 0.951
Data Source: STRINGDB
Publication Statistics
PubMed Score  863.50

PubMed score by year
PubTator Score  504.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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