Tbio GP2 Pancreatic secretory granule membrane major glycoprotein GP2

Protein Summary

Description

This gene encodes an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. The encoded protein binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Uniprot Accession IDs

• P55259
• A6NFM9
• A6NJA8
• Q13338
• Q9UIF1

Gene Name

• GP2

Ensembl ID

• ENST00000302555
• ENSP00000304044
• ENSG00000169347
• ENST00000341642
• ENSP00000343861
• ENST00000381360
• ENSP00000370765
• ENST00000381362
• ENSP00000370767

Symbol

• ZAP75

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.83
cellular component	0.66
cell line	0.61
cell type or tissue	0.52
tissue	0.48

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1070.01   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 369   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1070.01   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 369   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0