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Tbio
GP2
Pancreatic secretory granule membrane major glycoprotein GP2

Protein Summary
Description
This gene encodes an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. The encoded protein binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302555
  • ENSP00000304044
  • ENSG00000169347
  • ENST00000341642
  • ENSP00000343861
  • ENST00000381360
  • ENSP00000370765
  • ENST00000381362
  • ENSP00000370767

Symbol
  • ZAP75
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.83
cellular component
0.66
cell line
0.61
cell type or tissue
0.52
tissue
0.48


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 793.82   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 369   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 793.82   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 369   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1
1
1.1
83.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
83.7
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Protein-Protein Interactions (109)
1 – 10 of 109
GTPBP1
Tbio
Novelty: 0.00160825
Score: 0.931
Data Source: STRINGDB
NEGR1
Tbio
Novelty: 0.0088917
Score: 0.912
Data Source: STRINGDB
CEACAM5
Tbio
Novelty: 0.00007291
Score: 0.909
Data Source: STRINGDB
LYPD8
Tdark
Novelty: 0.15320165
Score: 0.908
Data Source: STRINGDB
VNN1
Tchem
Family: Enzyme
Novelty: 0.0144646
Score: 0.906
Data Source: STRINGDB
ALPL
Tchem
Family: Enzyme
Novelty: 0.00152281
Score: 0.905
Data Source: STRINGDB
SPACA4
Tdark
Novelty: 0.21569953
Score: 0.905
Data Source: STRINGDB
TECTA
Tbio
Novelty: 0.02462336
Score: 0.905
Data Source: STRINGDB
MSLN
Tbio
Novelty: 0.00191245
Score: 0.904
Data Source: STRINGDB
ALPI
Tbio
Family: Enzyme
Novelty: 0.00559196
Score: 0.904
Data Source: STRINGDB
Publication Statistics
PubMed Score  793.82

PubMed score by year
PubTator Score  272.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer