Tchem CASP9 Caspase-9

Protein Summary

Description

Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9. This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

Uniprot Accession IDs

• P55211
• B4E1A3
• O95348
• Q53Y70
• Q5JRU9
• Q5UGI1
• Q92852
• Q9BQ62
• Q9UEQ3
• Q9UIJ8
• CASP-9

Gene Name

• CASP9

Ensembl ID

• ENST00000333868
• ENSP00000330237
• ENSG00000132906
• ENST00000348549
• ENSP00000255256
• ENST00000375890
• ENSP00000365051

Symbol

• MCH6
• MCH6
• APAF3
• APAF-3
• PPP1R56
• ICE-LAP6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
chemical	1
kinase	0.99
protein domain	0.99
hub protein	0.95
biological process	0.92

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Cysteine Protease / Caspase-9

Protein / Enzyme Modulator / Protease Inhibitor / Caspase-9

DTO Classes

Protein / Enzyme / Protease / Cysteine Protease / Caspase-9

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3711.01   (req: < 5)

Gene RIFs: 262   (req: <= 3)

Antibodies: 1672   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3711.01   (req: >= 5)

Gene RIFs: 262   (req: > 3)

Antibodies: 1672   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 16

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0