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Tchem
CASP9
Caspase-9

Protein Summary
Description
Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9. This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333868
  • ENSP00000330237
  • ENSG00000132906
  • ENST00000348549
  • ENSP00000255256
  • ENST00000375890
  • ENSP00000365051

Symbol
  • MCH6
  • MCH6
  • APAF3
  • APAF-3
  • PPP1R56
  • ICE-LAP6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
kinase
0.99
protein domain
0.99
hub protein
0.95
biological process
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2690.91   (req: < 5)
Gene RIFs: 227   (req: <= 3)
Antibodies: 1672   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2690.91   (req: >= 5)
Gene RIFs: 227   (req: > 3)
Antibodies: 1672   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 13
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (10)
1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (107)
AKT phosphorylates targets in the cytosol (R-HSA-198323)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 25
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AKT phosphorylates targets in the cytosol
Reactome
Activation of caspases through apoptosome-mediated cleavage
Reactome
Apoptosis
Reactome
Apoptotic factor-mediated response
Reactome
Caspase activation via Dependence Receptors in the absence of ligand
Name
Explore in Pharos
Explore in Source
AKT phosphorylates targets in the cytosol
Activation of caspases through apoptosome-mediated cleavage
Apoptosis
Apoptotic factor-mediated response
Caspase activation via Dependence Receptors in the absence of ligand
Gene Ontology Terms (35)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (283)
1 – 10 of 283
BIRC8
Tchem
Novelty: 0.10093242
p_int: 0.916097331
p_wrong: 0.083902669
Score: 0.965
Data Source: BioPlex,STRINGDB
XIAP
Tchem
Family: Enzyme
Novelty: 0.00068225
Score: 0.999
Data Source: Reactome,STRINGDB
APAF1
Tbio
Family: Enzyme
Novelty: 0.00164778
Score: 0.999
Data Source: Reactome,STRINGDB
CYCS
Tchem
Novelty: 0.00018258
Score: 0.998
Data Source: Reactome,STRINGDB
AKT1
Tchem
Family: Kinase
Novelty: 0.0000383
Score: 0.994
Data Source: Reactome,STRINGDB
CASP8
Tchem
Family: Enzyme
Novelty: 0.00026844
Score: 0.994
Data Source: STRINGDB
CASP2
Tchem
Family: Enzyme
Novelty: 0.00224248
Score: 0.994
Data Source: STRINGDB
DIABLO
Tbio
Novelty: 0.00107224
Score: 0.989
Data Source: Reactome,STRINGDB
BIRC2
Tchem
Novelty: 0.00265344
Score: 0.987
Data Source: STRINGDB
BIRC3
Tchem
Novelty: 0.00226316
Score: 0.986
Data Source: STRINGDB
Publication Statistics
PubMed Score  2690.91

PubMed score by year
PubTator Score  3273.28

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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