Protein Classes
Protein Summary
Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9. This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase ...more
- ENST00000333868
- ENSP00000330237
- ENSG00000132906
- ENST00000348549
- ENSP00000255256
- ENST00000375890
- ENSP00000365051
- MCH6
- MCH6
- APAF3
- APAF-3
- PPP1R56
- ICE-LAP6
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
chemical | 1 | ||
kinase | 0.99 | ||
protein domain | 0.99 | ||
hub protein | 0.95 | ||
biological process | 0.92 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2690.91 (req: < 5)
Gene RIFs: 227 (req: <= 3)
Antibodies: 1672 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2690.91 (req: >= 5)
Gene RIFs: 227 (req: > 3)
Antibodies: 1672 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 29
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 13
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (13)
1 – 10 of 13
Protein Data Bank (10)
1 – 5 of 10
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (107)
Reactome (25)
KEGG (31)
PathwayCommons (17)
WikiPathways (34)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 25
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | AKT phosphorylates targets in the cytosol | ||||
Reactome | Activation of caspases through apoptosome-mediated cleavage | ||||
Reactome | Apoptosis | ||||
Reactome | Apoptotic factor-mediated response | ||||
Reactome | Caspase activation via Dependence Receptors in the absence of ligand | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
AKT phosphorylates targets in the cytosol | ||||
Activation of caspases through apoptosome-mediated cleavage | ||||
Apoptosis | ||||
Apoptotic factor-mediated response | ||||
Caspase activation via Dependence Receptors in the absence of ligand | ||||
Gene Ontology Terms (35)
Functions (8)
Components (6)
Processes (21)
Items per page:
10
1 – 8 of 8
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Protein-Protein Interactions (283)
1 – 10 of 283
BIRC8
Novelty: 0.10093242
p_int: 0.916097331
p_wrong: 0.083902669
Score: 0.965
Data Source: BioPlex,STRINGDB
XIAP
Family: Enzyme
Novelty: 0.00068225
Score: 0.999
Data Source: Reactome,STRINGDB
APAF1
Family: Enzyme
Novelty: 0.00164778
Score: 0.999
Data Source: Reactome,STRINGDB
CYCS
Novelty: 0.00018258
Score: 0.998
Data Source: Reactome,STRINGDB
AKT1
Family: Kinase
Novelty: 0.0000383
Score: 0.994
Data Source: Reactome,STRINGDB
CASP8
Family: Enzyme
Novelty: 0.00026844
Score: 0.994
Data Source: STRINGDB
CASP2
Family: Enzyme
Novelty: 0.00224248
Score: 0.994
Data Source: STRINGDB
DIABLO
Novelty: 0.00107224
Score: 0.989
Data Source: Reactome,STRINGDB
BIRC2
Novelty: 0.00265344
Score: 0.987
Data Source: STRINGDB
BIRC3
Novelty: 0.00226316
Score: 0.986
Data Source: STRINGDB
Publication Statistics
PubMed Score 2690.91
PubMed score by year
PubTator Score 3273.28
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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UniProt Keyword
GWAS Trait