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Tchem
CASP9
Caspase-9

Protein Summary
Description
Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9. This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333868
  • ENSP00000330237
  • ENSG00000132906
  • ENST00000348549
  • ENSP00000255256
  • ENST00000375890
  • ENSP00000365051

Symbol
  • MCH6
  • MCH6
  • APAF3
  • APAF-3
  • PPP1R56
  • ICE-LAP6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
kinase
0.99
protein domain
0.99
hub protein
0.95
biological process
0.92


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3592.87   (req: < 5)
Gene RIFs: 227   (req: <= 3)
Antibodies: 1672   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3592.87   (req: >= 5)
Gene RIFs: 227   (req: > 3)
Antibodies: 1672   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 13
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatinine measurement
1
1
1
27.4
glomerular filtration rate
1
1
1
27.4
1
1
0
1.6
25.8
urate measurement
1
1
1
18.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatinine measurement
1
27.4
glomerular filtration rate
1
27.4
0
1.6
25.8
urate measurement
1
18.3
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
caspase 9
694544
Mouse
MGI:1277950
12371
Rat
RGD:61867
58918
Dog
caspase 9
487432
Horse
caspase 9
VGNC:50673
100054331
Species
Name
OMA
EggNOG
Inparanoid
Macaque
caspase 9
Mouse
Rat
Dog
caspase 9
Horse
caspase 9
Protein Structure (10 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P55211-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (107)
AKT phosphorylates targets in the cytosol (R-HSA-198323)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 25
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AKT phosphorylates targets in the cytosol
Reactome
Activation of caspases through apoptosome-mediated cleavage
Reactome
Apoptosis
Reactome
Apoptotic factor-mediated response
Reactome
Caspase activation via Dependence Receptors in the absence of ligand
Name
Explore in Pharos
Explore in Source
AKT phosphorylates targets in the cytosol
Activation of caspases through apoptosome-mediated cleavage
Apoptosis
Apoptotic factor-mediated response
Caspase activation via Dependence Receptors in the absence of ligand
Gene Ontology Terms (35)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (283)
1 – 10 of 283
BIRC8
Tchem
Novelty: 0.05142518
p_int: 0.916097331
p_wrong: 0.083902669
Score: 0.965
Data Source: BioPlex,STRINGDB
XIAP
Tchem
Family: Enzyme
Novelty: 0.00062268
Score: 0.999
Data Source: Reactome,STRINGDB
APAF1
Tbio
Family: Enzyme
Novelty: 0.00107622
Score: 0.999
Data Source: Reactome,STRINGDB
CYCS
Tchem
Novelty: 0.00014004
Score: 0.998
Data Source: Reactome,STRINGDB
AKT1
Tchem
Family: Kinase
Novelty: 0.00003185
Score: 0.994
Data Source: Reactome,STRINGDB
CASP8
Tchem
Family: Enzyme
Novelty: 0.00024321
Score: 0.994
Data Source: STRINGDB
CASP2
Tchem
Family: Enzyme
Novelty: 0.00189892
Score: 0.994
Data Source: STRINGDB
DIABLO
Tbio
Novelty: 0.0007851
Score: 0.989
Data Source: Reactome,STRINGDB
BIRC2
Tchem
Novelty: 0.00199701
Score: 0.987
Data Source: STRINGDB
BIRC3
Tchem
Novelty: 0.00189613
Score: 0.986
Data Source: STRINGDB
Publication Statistics
PubMed Score  3592.87

PubMed score by year
PubTator Score  3273.28

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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