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Tchem
CASP9
Caspase-9

Protein Summary
Description
Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9. This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333868
  • ENSP00000330237
  • ENSG00000132906
  • ENST00000348549
  • ENSP00000255256
  • ENST00000375890
  • ENSP00000365051

Symbol
  • MCH6
  • MCH6
  • APAF3
  • APAF-3
  • PPP1R56
  • ICE-LAP6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
kinase
0.99
protein domain
0.99
hub protein
0.95
biological process
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3708.25   (req: < 5)
Gene RIFs: 227   (req: <= 3)
Antibodies: 1672   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3708.25   (req: >= 5)
Gene RIFs: 227   (req: > 3)
Antibodies: 1672   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 16
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (16)
SID24788424
Rendered image for SID24788424
CHEMBL23226
Rendered image for CHEMBL23226
CHEMBL237310
Rendered image for CHEMBL237310
CHEMBL180263
Rendered image for CHEMBL180263
SID24809205
Rendered image for SID24809205
CHEMBL2324339
Rendered image for CHEMBL2324339
CHEMBL2324341
Rendered image for CHEMBL2324341
CHEMBL185356
Rendered image for CHEMBL185356
CHEMBL90307
Rendered image for CHEMBL90307
Protein-Protein Interactions (283)
BIRC8
Tchem
Novelty:  0.05142518
p_int:  0.916097331
p_wrong:  0.083902669
Score:  0.965
Data Source:  BioPlex,STRINGDB
XIAP
Tchem
Family:  Enzyme
Novelty:  0.00062268
Score:  0.999
Data Source:  Reactome,STRINGDB
APAF1
Tchem
Family:  Enzyme
Novelty:  0.00107622
Score:  0.999
Data Source:  Reactome,STRINGDB
CYCS
Tchem
Novelty:  0.00014004
Score:  0.998
Data Source:  Reactome,STRINGDB
AKT1
Tchem
Family:  Kinase
Novelty:  0.00003185
Score:  0.994
Data Source:  Reactome,STRINGDB
CASP8
Tchem
Family:  Enzyme
Novelty:  0.00024321
Score:  0.994
Data Source:  STRINGDB
CASP2
Tchem
Family:  Enzyme
Novelty:  0.00189892
Score:  0.994
Data Source:  STRINGDB
DIABLO
Tbio
Novelty:  0.0007851
Score:  0.989
Data Source:  Reactome,STRINGDB
BIRC2
Tchem
Novelty:  0.00199701
Score:  0.987
Data Source:  STRINGDB
BIRC3
Tchem
Novelty:  0.00189613
Score:  0.986
Data Source:  STRINGDB
Nearest Tclin Targets (2)
Explore Nearest Tclin Targets
Pathways (107)
AKT phosphorylates targets in the cytosol (R-HSA-198323)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 25
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AKT phosphorylates targets in the cytosol
Reactome
Activation of caspases through apoptosome-mediated cleavage
Reactome
Apoptosis
Reactome
Apoptotic factor-mediated response
Reactome
Caspase activation via Dependence Receptors in the absence of ligand
Name
Explore in Pharos
Explore in Source
AKT phosphorylates targets in the cytosol
Activation of caspases through apoptosome-mediated cleavage
Apoptosis
Apoptotic factor-mediated response
Caspase activation via Dependence Receptors in the absence of ligand
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (35)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
7
7
6
8.2
94.6
urate measurement
3
4
4
92.5
1
6
0
1.6
91.9
creatinine measurement
4
4
4
84.3
body mass index
2
2
2
49.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
6
8.2
94.6
urate measurement
4
92.5
0
1.6
91.9
creatinine measurement
4
84.3
body mass index
2
49.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
caspase 9
694544
Mouse
MGI:1277950
12371
Rat
RGD:61867
58918
Dog
caspase 9
487432
Horse
caspase 9
VGNC:50673
100054331
Species
Name
OMA
EggNOG
Inparanoid
Macaque
caspase 9
Mouse
Rat
Dog
caspase 9
Horse
caspase 9
Publication Statistics
PubMed Score 3708.25
PubMed score by year
PubTator Score 3273.28
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title