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Tchem
CASP7
Caspase-7

Protein Summary
Description
Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death. This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345633
  • ENSP00000298701
  • ENSG00000165806
  • ENST00000369315
  • ENSP00000358321
  • ENST00000369318
  • ENSP00000358324
  • ENST00000369331
  • ENSP00000358337
  • ENST00000452490
  • ENSP00000398107
  • ENST00000614447
  • ENSP00000478285
  • ENST00000621345
  • ENSP00000480584
  • ENST00000621607
  • ENSP00000478999

Symbol
  • MCH3
  • MCH3
  • CMH-1
  • LICE2
  • CASP-7
  • ICE-LAP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
virus perturbation
1
hub protein
0.88
protein domain
0.85
gene perturbation
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 628.92   (req: < 5)
Gene RIFs: 83   (req: <= 3)
Antibodies: 991   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 628.92   (req: >= 5)
Gene RIFs: 83   (req: > 3)
Antibodies: 991   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 329
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
factor VII activating protease measurement
1
3
0
369
96.2
eosinophil percentage of leukocytes
2
1
2
73.7
eosinophil count
3
1
3
70.5
smoking status measurement
2
1
2
65.9
2
2
0
1.2
65.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
factor VII activating protease measurement
0
369
96.2
eosinophil percentage of leukocytes
2
73.7
eosinophil count
3
70.5
smoking status measurement
2
65.9
0
1.2
65.3
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
caspase 7
VGNC:3829
450745
Macaque
caspase 7
697633
Mouse
MGI:109383
12369
Rat
RGD:620944
64026
Dog
caspase 7
VGNC:38735
486896
Species
Name
OMA
EggNOG
Inparanoid
Chimp
caspase 7
Macaque
caspase 7
Mouse
Rat
Dog
caspase 7
Protein Structure (41 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P55210-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 41
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (108)
Activation of caspases through apoptosome-mediated cleavage (R-HSA-111459)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of caspases through apoptosome-mediated cleavage
Reactome
Apoptosis
Reactome
Apoptotic cleavage of cellular proteins
Reactome
Apoptotic execution phase
Reactome
Apoptotic factor-mediated response
Name
Explore in Pharos
Explore in Source
Activation of caspases through apoptosome-mediated cleavage
Apoptosis
Apoptotic cleavage of cellular proteins
Apoptotic execution phase
Apoptotic factor-mediated response
Gene Ontology Terms (13)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (201)
1 – 10 of 201
CASP8
Tchem
Family:  Enzyme
Novelty:  0.00024321
Score:  0.999
Data Source:  STRINGDB
XIAP
Tchem
Family:  Enzyme
Novelty:  0.00062268
Score:  0.996
Data Source:  Reactome,STRINGDB
APAF1
Tchem
Family:  Enzyme
Novelty:  0.00107622
Score:  0.993
Data Source:  STRINGDB
BIRC2
Tchem
Novelty:  0.00199701
Score:  0.99
Data Source:  STRINGDB
CASP10
Tchem
Family:  Enzyme
Novelty:  0.00724061
Score:  0.988
Data Source:  STRINGDB
CYCS
Tchem
Novelty:  0.00014004
Score:  0.981
Data Source:  STRINGDB
BIRC3
Tchem
Novelty:  0.00189613
Score:  0.981
Data Source:  STRINGDB
PARP1
Tclin
Family:  Enzyme
Novelty:  0.00033016
Score:  0.981
Data Source:  STRINGDB
CASP2
Tchem
Family:  Enzyme
Novelty:  0.00189892
Score:  0.966
Data Source:  STRINGDB
GZMB
Tchem
Family:  Enzyme
Novelty:  0.00052869
Score:  0.965
Data Source:  STRINGDB
Publication Statistics
PubMed Score  628.92

PubMed score by year
PubTator Score  905.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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