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Tbio
NAP1L1
Nucleosome assembly protein 1-like 1

Protein Summary
Description
Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity). This gene encodes a member of the nucleosome assembly protein (NAP) family. This protein participates in DNA replication and may play a role in modulating chromatin formation and contribute to the regulation of cell proliferation. Alternative splicing results in multiple transcript variants encoding different isoforms; however, not all have been fully described. [provided by RefSeq, Apr 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261182
  • ENSP00000261182
  • ENSG00000187109
  • ENST00000393263
  • ENSP00000376947
  • ENST00000431879
  • ENSP00000409795
  • ENST00000549596
  • ENSP00000447793
  • ENST00000618691
  • ENSP00000477538

Symbol
  • NRP
  • NRP
  • NAP1
  • NAP1L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor perturbation
1
viral protein
1
virus
1
disease perturbation
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.08   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 186   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.08   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 186   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (119)
1 – 10 of 119
FNTB
Tclin
Family:  Enzyme
Novelty:  0.07434994
p_int:  0.99999539
p_ni:  0.00000461
Score:  0.224
Data Source:  BioPlex,STRINGDB
RPL36AL
Tbio
Novelty:  0.09336423
p_int:  0.999909617
p_ni:  0.000090383
Score:  0.247
Data Source:  BioPlex,STRINGDB
RPL23A
Tbio
Novelty:  0.02951947
p_int:  0.999514076
p_ni:  0.000485925
Score:  0.238
Data Source:  BioPlex,STRINGDB
FNTA
Tclin
Family:  Enzyme
Novelty:  0.03163169
p_int:  0.999318383
p_ni:  0.000681617
Score:  0.823
Data Source:  BioPlex,STRINGDB
RPL24
Tbio
Novelty:  0.02160548
p_int:  0.997958651
p_ni:  0.002041349
Score:  0.521
Data Source:  BioPlex,STRINGDB
NAP1L4
Tbio
Novelty:  0.08710866
p_int:  0.993576597
p_ni:  0.006423402
Score:  0.839
Data Source:  BioPlex,STRINGDB
NAP1L5
Tbio
Novelty:  0.10378595
p_int:  0.992008587
p_ni:  0.007991413
Score:  0.351
Data Source:  BioPlex,STRINGDB
TFPI2
Tbio
Novelty:  0.00475383
p_int:  0.990482647
p_ni:  0.009517354
Data Source:  BioPlex
DGKZ
Tchem
Family:  Enzyme
Novelty:  0.01312044
p_int:  0.988865096
p_ni:  0.011134904
Score:  0.319
Data Source:  BioPlex,STRINGDB
SDAD1
Tdark
Novelty:  0.2574139
p_int:  0.988296041
p_ni:  0.011703959
Score:  0.751
Data Source:  BioPlex,STRINGDB
Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nucleosome assembly protein 1 like 1
VGNC:8471
452083
Macaque
nucleosome assembly protein 1 like 1
719047
Macaque
nucleosome assembly protein 1-like 1
706480
Mouse
MGI:1855693
53605
Rat
RGD:71094
89825
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nucleosome assembly protein 1 like 1
Macaque
nucleosome assembly protein 1 like 1
Macaque
nucleosome assembly protein 1-like 1
Mouse
Rat
Publication Statistics
PubMed Score 33.08
PubMed score by year
PubTator Score 175.47
PubTator score by year