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Tchem
BRPF1
Peregrin

Protein Summary
Description
Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:27939640). Preferentially mediates histone H3-K23 acetylation (PubMed:27939640). Positively regulates the transcription of RUNX1 and RUNX2 (PubMed:18794358). This gene encodes a bromodomain, PHD finger and chromo/Tudor-related Pro-Trp-Trp-Pro (PWWP) domain containing protein. The encoded protein is a component of the MOZ/MORF histone acetyltransferase complexes which function as a transcriptional regulators. This protein binds to the catalytic MYST domains of the MOZ and MORF proteins and may play a role in stimulating acetyltransferase and transcriptional activity of the complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000383829
  • ENSP00000373340
  • ENSG00000156983
  • ENST00000424362
  • ENSP00000398863
  • ENST00000433861
  • ENSP00000402485
  • ENST00000457855
  • ENSP00000410210

Symbol
  • BR140
  • BR140
  • IDDDFP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
histone modification site profile
0.76
disease perturbation
0.74
cell line
0.69
transcription factor binding site profile
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.73   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 43   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.73   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 43   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 107
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (107)
Bromosporine
Rendered image for Bromosporine
NI-57
Rendered image for NI-57
CHEMBL3774575
Rendered image for CHEMBL3774575
CHEMBL4102050
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CHEMBL4446421
Rendered image for CHEMBL4446421
CHEMBL4103077
Rendered image for CHEMBL4103077
CHEMBL4076056
Rendered image for CHEMBL4076056
OF-1
Rendered image for OF-1
CHEMBL4069814
Rendered image for CHEMBL4069814
CHEMBL4648548
Rendered image for CHEMBL4648548
Protein-Protein Interactions (96)
MEAF6
Tbio
Novelty:  0.0914094
p_int:  0.999999772
p_ni:  2.25e-7
p_wrong:  3e-9
Score:  0.987
Data Source:  BioPlex,Reactome,STRINGDB
ARRB1
Tbio
Novelty:  0.00262758
p_int:  0.99999922
p_ni:  7.76e-7
p_wrong:  4e-9
Score:  0.82
Data Source:  BioPlex,STRINGDB
ARRB2
Tbio
Novelty:  0.00148149
p_int:  0.999998135
p_ni:  0.000001863
p_wrong:  2e-9
Score:  0.65
Data Source:  BioPlex,STRINGDB
PLCD4
Tbio
Family:  Enzyme
Novelty:  0.07014141
p_int:  0.999976036
p_ni:  0.000015909
p_wrong:  0.000008055
Data Source:  BioPlex
PIP4K2A
Tbio
Family:  Kinase
Novelty:  0.01130885
p_int:  0.999965577
p_ni:  0.000034338
p_wrong:  8.6e-8
Score:  0.167
Data Source:  BioPlex,STRINGDB
KAT6A
Tchem
Family:  Epigenetic
Novelty:  0.00478771
Score:  0.995
Data Source:  Reactome,STRINGDB
KAT6B
Tchem
Family:  Epigenetic
Novelty:  0.00361345
Score:  0.992
Data Source:  Reactome,STRINGDB
ING5
Tbio
Family:  Epigenetic
Novelty:  0.03585867
Score:  0.976
Data Source:  Reactome,STRINGDB
HIST2H3A
Tbio
Novelty:  0.02749981
Score:  0.954
Data Source:  STRINGDB
HIST1H3A
Tbio
Novelty:  0.00991842
Score:  0.951
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Gene expression (Transcription)
Generic Transcription Pathway
HATs acetylate histones
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
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Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
1
1
0
9.3
73
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
0
9.3
73
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
bromodomain and PHD finger containing 1
VGNC:1747
460151
Macaque
bromodomain and PHD finger containing 1
699850
Mouse
MGI:1926033
78783
Rat
RGD:1584828
679713
Dog
bromodomain and PHD finger containing 1
VGNC:38533
484667
Species
Name
OMA
EggNOG
Inparanoid
Chimp
bromodomain and PHD finger containing 1
Macaque
bromodomain and PHD finger containing 1
Mouse
Rat
Dog
bromodomain and PHD finger containing 1
Publication Statistics
PubMed Score 34.73
PubMed score by year
PubTator Score 23.36
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title