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Tchem
BRPF1
Peregrin

Protein Summary
Description
Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:27939640). Preferentially mediates histone H3-K23 acetylation (PubMed:27939640). Positively regulates the transcription of RUNX1 and RUNX2 (PubMed:18794358). This gene encodes a bromodomain, PHD finger and chromo/Tudor-related Pro-Trp-Trp-Pro (PWWP) domain containing protein. The encoded protein is a component of the MOZ/MORF histone acetyltransferase complexes which function as a transcriptional regulators. This protein binds to the catalytic MYST domains of the MOZ and MORF proteins and may play a role in stimulating acetyltransferase and transcriptional activity of the complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000383829
  • ENSP00000373340
  • ENSG00000156983
  • ENST00000424362
  • ENSP00000398863
  • ENST00000433861
  • ENSP00000402485
  • ENST00000457855
  • ENSP00000410210

Symbol
  • BR140
  • BR140
  • IDDDFP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
histone modification site profile
0.76
disease perturbation
0.74
cell line
0.69
transcription factor binding site profile
0.67


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.52   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 43   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.52   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 43   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 62
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (62)
1 – 10 of 62
CHEMBL3774575
chemical structure image
CHEMBL3770173
chemical structure image
CHEMBL3752151
chemical structure image
CHEMBL1522313
chemical structure image
CHEMBL3770456
chemical structure image
CHEMBL3770259
chemical structure image
CHEMBL3769965
chemical structure image
CHEMBL3771002
chemical structure image
CHEMBL3769887
chemical structure image
CHEMBL1444120
chemical structure image
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
bromodomain and PHD finger containing 1
VGNC:1747
460151
Macaque
bromodomain and PHD finger containing 1
699850
Mouse
MGI:1926033
78783
Rat
RGD:1584828
679713
Dog
bromodomain and PHD finger containing 1
VGNC:38533
484667
Species
Name
OMA
EggNOG
Inparanoid
Chimp
bromodomain and PHD finger containing 1
Macaque
bromodomain and PHD finger containing 1
Mouse
Rat
Dog
bromodomain and PHD finger containing 1
Protein Structure (61 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P55201-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 61
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (9)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Gene expression (Transcription)
Generic Transcription Pathway
HATs acetylate histones
Gene Ontology Terms (12)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (96)
1 – 10 of 96
MEAF6
Tbio
Novelty: 0.0914094
p_int: 0.999999772
p_ni: 2.25e-7
p_wrong: 3e-9
Score: 0.987
Data Source: BioPlex,Reactome,STRINGDB
ARRB1
Tbio
Novelty: 0.00262758
p_int: 0.99999922
p_ni: 7.76e-7
p_wrong: 4e-9
Score: 0.82
Data Source: BioPlex,STRINGDB
ARRB2
Tbio
Novelty: 0.00148149
p_int: 0.999998135
p_ni: 0.000001863
p_wrong: 2e-9
Score: 0.65
Data Source: BioPlex,STRINGDB
PLCD4
Tbio
Family: Enzyme
Novelty: 0.07014141
p_int: 0.999976036
p_ni: 0.000015909
p_wrong: 0.000008055
Data Source: BioPlex
PIP4K2A
Tbio
Family: Kinase
Novelty: 0.01130885
p_int: 0.999965577
p_ni: 0.000034338
p_wrong: 8.6e-8
Score: 0.167
Data Source: BioPlex,STRINGDB
KAT6A
Tbio
Family: Epigenetic
Novelty: 0.00478771
Score: 0.995
Data Source: Reactome,STRINGDB
KAT6B
Tbio
Family: Epigenetic
Novelty: 0.00361345
Score: 0.992
Data Source: Reactome,STRINGDB
ING5
Tbio
Family: Epigenetic
Novelty: 0.03585867
Score: 0.976
Data Source: Reactome,STRINGDB
HIST2H3A
Tbio
Novelty: 0.02749981
Score: 0.954
Data Source: STRINGDB
HIST1H3A
Tbio
Novelty: 0.00991842
Score: 0.951
Data Source: STRINGDB
Publication Statistics
PubMed Score  33.52

PubMed score by year
PubTator Score  23.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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