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Tbio
MLLT10
Protein AF-10

Protein Summary
Description
Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302). This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307729
  • ENSP00000307411
  • ENSG00000078403
  • ENST00000377059
  • ENSP00000366258
  • ENST00000377072
  • ENSP00000366272
  • ENST00000377091
  • ENSP00000366295
  • ENST00000377100
  • ENSP00000366304
  • ENST00000621220
  • ENSP00000484335
  • ENST00000631589
  • ENSP00000488569

Symbol
  • AF10
  • AF10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
transcription factor binding site profile
0.92
transcription factor perturbation
0.84
protein domain
0.73
transcription factor
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 170.36   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 355   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 170.36   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 355   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
2
3
97.8
waist-hip ratio
2
2
2
92
Meningioma
1
1
0
1.5
86.5
lifestyle measurement
1
1
1
83.4
4
2
0
1.1
82.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
97.8
waist-hip ratio
2
92
Meningioma
0
1.5
86.5
lifestyle measurement
1
83.4
0
1.1
82.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MLLT10, histone lysine methyltransferase DOT1L cofactor
VGNC:14870
450343
Macaque
protein AF-10
709083
Mouse
MGI:1329038
17354
Rat
RGD:1310874
361285
Dog
MLLT10, histone lysine methyltransferase DOT1L cofactor
VGNC:50637
487096
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MLLT10, histone lysine methyltransferase DOT1L cofactor
Macaque
protein AF-10
Mouse
Rat
Dog
MLLT10, histone lysine methyltransferase DOT1L cofactor
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P55197-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (11)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Non-traceable Author Statement (NAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (91)
1 – 10 of 91
MLLT6
Tdark
Family: Epigenetic
Novelty: 0.03728427
p_int: 0.999999987
p_ni: 1.1e-8
p_wrong: 1e-9
Score: 0.343
Data Source: BioPlex,STRINGDB
DAXX
Tbio
Novelty: 0.00348585
p_int: 0.999999892
p_ni: 1.01e-7
p_wrong: 7e-9
Data Source: BioPlex
TCP10L
Tbio
Novelty: 0.24089479
p_int: 0.999904816
p_ni: 0.00008852
p_wrong: 0.000006664
Score: 0.173
Data Source: BioPlex,STRINGDB
KIF6
Tbio
Novelty: 0.02486302
p_int: 0.985212856
p_ni: 0.000073925
p_wrong: 0.014713219
Score: 0.295
Data Source: BioPlex,STRINGDB
PMF1
Tbio
Novelty: 0.05319446
p_int: 0.978354801
p_ni: 0.000074258
p_wrong: 0.021570942
Data Source: BioPlex
MLLT3
Tbio
Novelty: 0.00361056
Score: 0.918
Data Source: STRINGDB
DOT1L
Tchem
Family: Epigenetic
Novelty: 0.00361358
Score: 0.917
Data Source: STRINGDB
MLLT1
Tbio
Novelty: 0.00328241
Score: 0.911
Data Source: STRINGDB
YEATS4
Tbio
Novelty: 0.02632024
Score: 0.862
Data Source: STRINGDB
AFF1
Tbio
Family: TF
Novelty: 0.00094358
Score: 0.844
Data Source: STRINGDB
Publication Statistics
PubMed Score  170.36

PubMed score by year
PubTator Score  88.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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