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Tbio
AFDN
Afadin

Protein Summary
Description
Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton. This gene encodes a multi-domain protein involved in signaling and organization of cell junctions during embryogenesis. It has also been identified as the fusion partner of acute lymphoblastic leukemia (ALL-1) gene, involved in acute myeloid leukemias with t(6;11)(q27;q23) translocation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, however, not all have been fully characterized.[provided by RefSeq, May 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000392108
  • ENSP00000375956
  • ENSG00000130396
  • ENST00000392112
  • ENSP00000375960
  • ENST00000400822
  • ENSP00000383623
  • ENST00000447894
  • ENSP00000404595

Symbol
  • AF6
  • MLLT4
  • AF6
  • MLLT4
  • MLL-AF6
  • l-afadin
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 236.22   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 251   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 236.22   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 251   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
1
1
1
63
red blood cell distribution width
2
1
2
49.3
reticulocyte measurement
1
1
1
29.6
serum non-albumin protein measurement
1
1
1
10.4
mean reticulocyte volume
1
1
1
7.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
1
63
red blood cell distribution width
2
49.3
reticulocyte measurement
1
29.6
serum non-albumin protein measurement
1
10.4
mean reticulocyte volume
1
7.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
afadin, adherens junction formation factor
VGNC:14790
463135
Macaque
afadin, adherens junction formation factor
693560
Mouse
MGI:1314653
17356
Dog
afadin, adherens junction formation factor
VGNC:37685
431695
Horse
afadin, adherens junction formation factor
VGNC:15143
100054846
Species
Name
OMA
EggNOG
Inparanoid
Chimp
afadin, adherens junction formation factor
Macaque
afadin, adherens junction formation factor
Mouse
Dog
afadin, adherens junction formation factor
Horse
afadin, adherens junction formation factor
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P55196-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (87)
Adherens junctions interactions (R-HSA-418990)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adherens junctions interactions
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Name
Explore in Pharos
Explore in Source
Adherens junctions interactions
Cell junction organization
Cell-Cell communication
Cell-cell junction organization
Gene Ontology Terms (26)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ARUK-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (183)
1 – 10 of 183
CPNE2
Tdark
Novelty: 0.24188419
p_int: 0.999998577
p_ni: 0.000001423
Data Source: BioPlex
NCK2
Tbio
Novelty: 0.02220251
p_int: 0.999996599
p_ni: 0.000003401
Data Source: BioPlex
FGL1
Tbio
Novelty: 0.02650803
p_int: 0.999971478
p_ni: 0.000028522
Data Source: BioPlex
KLHDC3
Tdark
Novelty: 0.63840156
p_int: 0.998436809
p_ni: 0.001563176
p_wrong: 1.6e-8
Data Source: BioPlex
CYP1A1
Tchem
Novelty: 0.0002404
p_int: 0.998142363
p_ni: 0.001850871
p_wrong: 0.000006766
Score: 0.158
Data Source: BioPlex,STRINGDB
ABLIM3
Tdark
Novelty: 0.28184092
p_int: 0.99672116
p_ni: 0.003278793
p_wrong: 4.7e-8
Data Source: BioPlex
FGF9
Tbio
Novelty: 0.003428
p_int: 0.993002021
p_ni: 0.00699795
p_wrong: 2.9e-8
Score: 0.165
Data Source: BioPlex,STRINGDB
MRPS11
Tdark
Novelty: 0.29449255
p_int: 0.987553028
p_ni: 0.012446913
p_wrong: 5.8e-8
Data Source: BioPlex
HIF1AN
Tbio
Novelty: 0.00861018
p_int: 0.984386183
p_ni: 0.015613809
p_wrong: 8e-9
Data Source: BioPlex
ABLIM2
Tdark
Novelty: 0.23629309
p_int: 0.984146603
p_ni: 0.00356681
p_wrong: 0.012286587
Data Source: BioPlex
Publication Statistics
PubMed Score  236.22

PubMed score by year
PubTator Score  119.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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