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Tclin
MTTP
Microsomal triglyceride transfer protein large subunit

Protein Summary
Description
Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces (PubMed:23475612, PubMed:8939939, PubMed:26224785, PubMed:25108285, PubMed:22236406). Required for the secretion of plasma lipoproteins that contain apolipoprotein B (PubMed:23475612, PubMed:8939939, PubMed:26224785). MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265517
  • ENSP00000265517
  • ENSG00000138823
  • ENST00000422897
  • ENSP00000407350
  • ENST00000457717
  • ENSP00000400821

Symbol
  • MTP
  • ABL
  • MTP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
1
histone modification site profile
0.78
biological term
0.76
transcription factor binding site profile
0.7
cellular component
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 372.71   (req: < 5)
Gene RIFs: 99   (req: <= 3)
Antibodies: 229   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 372.71   (req: >= 5)
Gene RIFs: 99   (req: > 3)
Antibodies: 229   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 149
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
lomitapide
chemical structure image
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol use disorder measurement
1
1
0
5.8
51
high density lipoprotein cholesterol measurement
1
1
1
45.4
triglyceride measurement
1
1
1
42
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol use disorder measurement
0
5.8
51
high density lipoprotein cholesterol measurement
1
45.4
triglyceride measurement
1
42
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
microsomal triglyceride transfer protein
VGNC:642
471397
Macaque
microsomal triglyceride transfer protein
708832
Mouse
MGI:106926
17777
Rat
RGD:1308388
310900
Dog
microsomal triglyceride transfer protein
VGNC:43495
487873
Species
Name
OMA
EggNOG
Inparanoid
Chimp
microsomal triglyceride transfer protein
Macaque
microsomal triglyceride transfer protein
Mouse
Rat
Dog
microsomal triglyceride transfer protein
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P55157-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (17)
Chylomicron assembly (R-HSA-8963888)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chylomicron assembly
Reactome
Plasma lipoprotein assembly
Reactome
Plasma lipoprotein assembly, remodeling, and clearance
Reactome
Transport of small molecules
Reactome
VLDL assembly
Name
Explore in Pharos
Explore in Source
Chylomicron assembly
Plasma lipoprotein assembly
Plasma lipoprotein assembly, remodeling, and clearance
Transport of small molecules
VLDL assembly
Protein-Protein Interactions (90)
1 – 10 of 90
APOB
Tchem
Novelty: 0.00008247
Score: 0.997
Data Source: Reactome,STRINGDB
P4HB
Tbio
Family: Enzyme
Novelty: 0.00107905
Score: 0.987
Data Source: Reactome,STRINGDB
APOA1
Tbio
Novelty: 0.0001216
Score: 0.98
Data Source: STRINGDB
APOA4
Tbio
Novelty: 0.00305835
Score: 0.96
Data Source: STRINGDB
APOA2
Tbio
Novelty: 0.00117627
Score: 0.954
Data Source: STRINGDB
APOC3
Tclin
Novelty: 0.0009635
Score: 0.834
Data Source: STRINGDB
APOO
Tbio
Novelty: 0.04964756
Score: 0.801
Data Source: STRINGDB
FABP1
Tchem
Novelty: 0.00192691
Score: 0.792
Data Source: STRINGDB
INS
Tbio
Novelty: 0.00000499
Score: 0.766
Data Source: STRINGDB
NR0B2
Tchem
Family: NR
Novelty: 0.0009861
Score: 0.737
Data Source: STRINGDB
Publication Statistics
PubMed Score  372.71

PubMed score by year
PubTator Score  192.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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