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Tbio
MANF
Mesencephalic astrocyte-derived neurotrophic factor

Protein Summary
Description
Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain (PubMed:12794311). Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra (By similarity). Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death (PubMed:18561914, PubMed:22637475, PubMed:29497057). Retained in the ER/sarcoplasmic reticulum (SR) through association with the endoplasmic reticulum chaperone protein HSPA5 under normal conditions (PubMed:22637475). Up-regulated and secreted by the ER/SR in response to ER stress and hypoxia (PubMed:22637475). Following secretion by the ER/SR, directly binds to 3-O-sulfogalactosylceramide, a lipid sulfatide in the outer cell membrane of target cells (PubMed:29497057). Sulfatide binding promotes its cellular uptake by endocytosis, and is required for its role in alleviating ER st ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000627526
  • ENSP00000487450
  • ENSG00000145050

Symbol
  • ARMET
  • ARP
  • ARP
  • ARMET
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
gene perturbation
0.91
transcription factor binding site profile
0.77
disease perturbation
0.74
virus perturbation
0.68


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 203.38   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 203.38   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mesencephalic astrocyte derived neurotrophic factor
VGNC:7075
745542
Mouse
MGI:1922090
74840
Rat
RGD:1307252
315989
Dog
mesencephalic astrocyte derived neurotrophic factor
VGNC:42951
100855747
Horse
mesencephalic astrocyte derived neurotrophic factor
VGNC:19916
100052301
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mesencephalic astrocyte derived neurotrophic factor
Mouse
Rat
Dog
mesencephalic astrocyte derived neurotrophic factor
Horse
mesencephalic astrocyte derived neurotrophic factor
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P55145-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Reactome
Response to elevated platelet cytosolic Ca2+
Name
Explore in Pharos
Explore in Source
Hemostasis
Platelet activation, signaling and aggregation
Platelet degranulation
Response to elevated platelet cytosolic Ca2+
Gene Ontology Terms (14)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (98)
1 – 10 of 98
BCL2L15
Tbio
Novelty: 0.11260258
p_int: 0.948190514
p_ni: 0.051702046
p_wrong: 0.00010744
Score: 0.685
Data Source: BioPlex,STRINGDB
MICB
Tbio
Novelty: 0.00364639
p_int: 0.924100388
p_ni: 0.075899612
Data Source: BioPlex
ADAM21
Tdark
Family: Enzyme
Novelty: 0.16068055
p_int: 0.908880226
p_ni: 0.091119774
Score: 0.237
Data Source: BioPlex,STRINGDB
HSPA5
Tchem
Novelty: 0.00043424
Score: 0.975
Data Source: STRINGDB
CRELD2
Tbio
Novelty: 0.09438775
Score: 0.97
Data Source: STRINGDB
HSP90B1
Tchem
Novelty: 0.00135881
Score: 0.963
Data Source: STRINGDB
PDIA4
Tbio
Family: Enzyme
Novelty: 0.01412168
Score: 0.955
Data Source: STRINGDB
HYOU1
Tbio
Novelty: 0.00833649
Score: 0.946
Data Source: STRINGDB
DNAJB11
Tbio
Novelty: 0.02588745
Score: 0.945
Data Source: STRINGDB
PDIA6
Tchem
Family: Enzyme
Novelty: 0.01692178
Score: 0.933
Data Source: STRINGDB
Publication Statistics
PubMed Score  203.38

PubMed score by year
PubTator Score  178.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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