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Tbio
INHBC
Inhibin beta C chain

Protein Summary
Description
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of homodimeric and heterodimeric activin complexes. The heterodimeric complex may function in the inhibition of activin A signaling. Transgenic mice overexpressing this gene exhibit defects in testis, liver and prostate. [provided by RefSeq, Aug 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309668
  • ENSP00000308716
  • ENSG00000175189

Symbol
  • IHBC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
cell type or tissue
0.7
disease perturbation
0.62
gene perturbation
0.62
cell line
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.76   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 287   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.76   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 287   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
2
3
7
95.3
triglyceride measurement
2
3
7
90.4
urate measurement
2
1
2
84.4
uric acid measurement
1
1
1
72.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
7
95.3
triglyceride measurement
7
90.4
urate measurement
2
84.4
uric acid measurement
1
72.4
Pathways (15)
Glycoprotein hormones (R-HSA-209822)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycoprotein hormones
Reactome
Metabolism of proteins
Reactome
Peptide hormone biosynthesis
Reactome
Peptide hormone metabolism
Name
Explore in Pharos
Explore in Source
Glycoprotein hormones
Metabolism of proteins
Peptide hormone biosynthesis
Peptide hormone metabolism
Protein-Protein Interactions (38)
1 – 10 of 38
INHA
Tbio
Novelty: 0.00168407
Score: 0.961
Data Source: Reactome,STRINGDB
ACVR1
Tchem
Family: Kinase
Novelty: 0.00284646
Score: 0.928
Data Source: STRINGDB
ACVR1B
Tchem
Family: Kinase
Novelty: 0.00633595
Score: 0.927
Data Source: STRINGDB
ACVR2A
Tchem
Family: Kinase
Novelty: 0.0063932
Score: 0.919
Data Source: STRINGDB
ACVR2B
Tchem
Family: Kinase
Novelty: 0.00555742
Score: 0.913
Data Source: STRINGDB
CGA
Tbio
Novelty: 0.00394017
Score: 0.9
Data Source: STRINGDB
FSHB
Tbio
Novelty: 0.00510815
Score: 0.9
Data Source: STRINGDB
FST
Tbio
Novelty: 0.00085875
Score: 0.881
Data Source: STRINGDB
NODAL
Tbio
Novelty: 0.01033642
Score: 0.817
Data Source: STRINGDB
ACVR1C
Tbio
Family: Kinase
Novelty: 0.01675672
Score: 0.783
Data Source: STRINGDB
Publication Statistics
PubMed Score  15.76

PubMed score by year
PubTator Score  5.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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