Tbio AQP4 Aquaporin-4

Protein Summary

Description

Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system. This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. This protein is the predominant aquaporin found in brain and has an important role in brain water homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. Additional isoforms, resulting from the use of alternative in-frame translation initiation codons, have also been described. Recent studies provided evidence for translational readthrough in this gene, and expression of C-terminally extended isoforms via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Jun 2018]

Uniprot Accession IDs

• P55087
• P78564
• AQP-4

Gene Name

• AQP4

Ensembl ID

• ENST00000383168
• ENSP00000372654
• ENSG00000171885
• ENST00000440832
• ENSP00000393121
• ENST00000581374
• ENSP00000462597

Symbol

• MIWC
• WCH4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.83
kinase perturbation	0.81
biological term	0.79
cellular component	0.73
biological process	0.7

Protein Classes

PANTHER Classes

Protein / Transporter / Aquaporin-4

DTO Classes

Protein / Ion Channel / Other Ion Channel / Aquaporin / Aquaporin-4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4365.6   (req: < 5)

Gene RIFs: 301   (req: <= 3)

Antibodies: 520   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4365.6   (req: >= 5)

Gene RIFs: 301   (req: > 3)

Antibodies: 520   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0