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Tbio
AQP4
Aquaporin-4

Protein Summary
Description
Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system. This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. This protein is the predominant aquaporin found in brain and has an important role in brain water homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. Additional isoforms, resulting from the use of alternative in-frame translation initiation codons, have also been described. Recent studies provided evidence for translational readthrough in this gene, and expression of C-terminally extended isoforms via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Jun 2018]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000383168
  • ENSP00000372654
  • ENSG00000171885
  • ENST00000440832
  • ENSP00000393121
  • ENST00000581374
  • ENSP00000462597

Symbol
  • MIWC
  • WCH4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.83
kinase perturbation
0.81
biological term
0.79
cellular component
0.73
biological process
0.7


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3521.87   (req: < 5)
Gene RIFs: 226   (req: <= 3)
Antibodies: 520   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3521.87   (req: >= 5)
Gene RIFs: 226   (req: > 3)
Antibodies: 520   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aquaporin 4
VGNC:5142
455350
Macaque
aquaporin 4
703773
Mouse
MGI:107387
11829
Rat
RGD:2143
25293
Dog
aquaporin 4
VGNC:38018
612628
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aquaporin 4
Macaque
aquaporin 4
Mouse
Rat
Dog
aquaporin 4
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P55087-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (11)
Aquaporin-mediated transport (R-HSA-445717)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aquaporin-mediated transport
Reactome
Passive transport by Aquaporins
Reactome
Transport of small molecules
Reactome
Vasopressin regulates renal water homeostasis via Aquaporins
Name
Explore in Pharos
Explore in Source
Aquaporin-mediated transport
Passive transport by Aquaporins
Transport of small molecules
Vasopressin regulates renal water homeostasis via Aquaporins
Protein-Protein Interactions (190)
1 – 10 of 190
KCNJ10
Tbio
Family: IC
Novelty: 0.00273462
Score: 0.903
Data Source: STRINGDB
GFAP
Tbio
Novelty: 0.00020932
Score: 0.896
Data Source: STRINGDB
SLC1A2
Tchem
Family: Transporter
Novelty: 0.00086733
Score: 0.887
Data Source: STRINGDB
AQP12A
Tbio
Novelty: 0.04258853
Score: 0.862
Data Source: STRINGDB
AQP11
Tbio
Novelty: 0.0229197
Score: 0.858
Data Source: STRINGDB
MOG
Tbio
Novelty: 0.00048664
Score: 0.852
Data Source: STRINGDB
GRM5
Tchem
Family: GPCR
Novelty: 0.00062552
Score: 0.764
Data Source: STRINGDB
AGRN
Tbio
Novelty: 0.00156441
Score: 0.762
Data Source: STRINGDB
SLC1A3
Tchem
Family: Transporter
Novelty: 0.00127305
Score: 0.752
Data Source: STRINGDB
MBP
Tbio
Novelty: 0.00016333
Score: 0.72
Data Source: STRINGDB
Publication Statistics
PubMed Score  3521.87

PubMed score by year
PubTator Score  1645.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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