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Tchem
F2RL1
Proteinase-activated receptor 2

Protein Summary
Description
Receptor for trypsin and trypsin-like enzymes coupled to G proteins (PubMed:28445455). Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF-kappaB and Rho (PubMed:28445455). Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can signal synergistically with TLR4 and probably TLR2 in inflammatory responses and modulates TLR3 signaling. Has a protective role in establishing the endothelial barrier; the activity involves coagulation factor X. Regulates endothelial cell barrier integrity during neutrophil extravasation, probably following proteolytic cleavage by PRTN3 (PubMed:23202369). Proposed to have a bronchoprotective role in airway epithelium, bu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296677
  • ENSP00000296677
  • ENSG00000164251

Symbol
  • GPR11
  • PAR2
  • PAR2
  • GPR11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
0.99
PubMedID
0.95
gene perturbation
0.93
transcription factor perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 278.03   (req: < 5)
Gene RIFs: 296   (req: <= 3)
Antibodies: 301   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 278.03   (req: >= 5)
Gene RIFs: 296   (req: > 3)
Antibodies: 301   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 58
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 35
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (206)
SLMAP
Tbio
Novelty:  0.03974856
p_int:  0.999269008
p_ni:  0.000730992
Score:  0.234
Data Source:  BioPlex,STRINGDB
HSDL2
Tbio
Family:  Enzyme
Novelty:  0.07946749
p_int:  0.882216098
p_ni:  0.117783902
Score:  0.282
Data Source:  BioPlex,STRINGDB
INTS12
Tbio
Family:  Epigenetic
Novelty:  0.09023473
p_int:  0.881680222
p_ni:  0.118319766
p_wrong:  1.2e-8
Score:  0.201
Data Source:  BioPlex,STRINGDB
C19orf25
Tdark
Novelty:  8.61479932
p_int:  0.752299332
p_ni:  0.247664541
p_wrong:  0.000036127
Score:  0.237
Data Source:  BioPlex,STRINGDB
F2
Tclin
Family:  Enzyme
Novelty:  0.00004833
Score:  0.959
Data Source:  Reactome,STRINGDB
TAC1
Tbio
Novelty:  0.00006575
Score:  0.948
Data Source:  STRINGDB
NPS
Tbio
Novelty:  0.00692108
Score:  0.935
Data Source:  STRINGDB
KNG1
Tbio
Novelty:  0.00007684
Score:  0.926
Data Source:  STRINGDB
PTGER1
Tclin
Family:  GPCR
Novelty:  0.0013716
Score:  0.926
Data Source:  STRINGDB
GNA14
Tbio
Novelty:  0.0587776
Score:  0.921
Data Source:  STRINGDB
Pathways (13)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (63)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
2
88.8
blood protein measurement
1
1
1
47.7
proteinase-activated receptor 1 measurement
1
1
1
32.8
reticulocyte count
1
1
1
12.8
platelet count
1
1
0
6.1
5.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
88.8
blood protein measurement
1
47.7
proteinase-activated receptor 1 measurement
1
32.8
reticulocyte count
1
12.8
platelet count
0
6.1
5.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
F2R like trypsin receptor 1
VGNC:11943
461800
Mouse
MGI:101910
14063
Rat
RGD:620866
116677
Dog
F2R like trypsin receptor 1
VGNC:40549
488940
Horse
F2R like trypsin receptor 1 [Source:HGNC Symbol;Acc:HGNC:3538]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
F2R like trypsin receptor 1
Mouse
Rat
Dog
F2R like trypsin receptor 1
Horse
F2R like trypsin receptor 1 [Source:HGNC Symbol;Acc:HGNC:3538]
Publication Statistics
PubMed Score 278.03
PubMed score by year
PubTator Score 642.38
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title