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Tbio
DIO3
Thyroxine 5-deiodinase

Protein Summary
Description
Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development. The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in pregnant uterus, placenta, fetal and neonatal tissues, and thought to prevent premature exposure of dev ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000510508
  • ENSP00000427336
  • ENSG00000197406

Symbol
  • ITDI3
  • TXDI3
  • D3
  • 5DIII
  • TXDI3
  • DIOIII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.74
PubMedID
0.65
chemical
0.6
tissue
0.6
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 240.3   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 290   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 240.3   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 290   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (66)
1 – 10 of 66
DIO2
Tbio
Family:  Enzyme
Novelty:  0.00173094
Score:  0.92
Data Source:  STRINGDB
DIO1
Tclin
Family:  Enzyme
Novelty:  0.01035036
Score:  0.911
Data Source:  STRINGDB
DLK1
Tchem
Novelty:  0.00212394
Score:  0.897
Data Source:  STRINGDB
RTL1
Tbio
Novelty:  0.0181401
Score:  0.829
Data Source:  STRINGDB
TRH
Tbio
Novelty:  0.00052673
Score:  0.745
Data Source:  STRINGDB
EYA3
Tbio
Novelty:  0.05588286
Score:  0.712
Data Source:  STRINGDB
SLC16A2
Tbio
Family:  Transporter
Novelty:  0.00353339
Score:  0.698
Data Source:  STRINGDB
SELENOV
Tdark
Novelty:  0.05279914
Score:  0.698
Data Source:  STRINGDB
SLC16A10
Tbio
Family:  Transporter
Novelty:  0.02363735
Score:  0.65
Data Source:  STRINGDB
SLC7A8
Tbio
Family:  Transporter
Novelty:  0.03433454
Score:  0.643
Data Source:  STRINGDB
Pathways (8)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amine-derived hormones
Reactome
Metabolism of amino acids and derivatives
Reactome
Regulation of thyroid hormone activity
Reactome
Thyroxine biosynthesis
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amine-derived hormones
Metabolism of amino acids and derivatives
Regulation of thyroid hormone activity
Thyroxine biosynthesis
Gene Ontology Terms (14)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
2
2
32.7
thyroxine measurement
1
1
1
15.4
pulse pressure measurement
1
1
1
5.3
self reported educational attainment
1
1
1
4.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
32.7
thyroxine measurement
1
15.4
pulse pressure measurement
1
5.3
self reported educational attainment
1
4.2
Find similar targets by:
Publication Statistics
PubMed Score 240.30
PubMed score by year
PubTator Score 319.47
PubTator score by year