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Tchem
VCP
Transitional endoplasmic reticulum ATPase

Protein Summary
Description
Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358901
  • ENSP00000351777
  • ENSG00000165280

Symbol
  • p97
  • TERA
  • CDC48
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
molecular function
1
protein domain
1
kinase perturbation
0.99
biological process
0.98


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1081.17   (req: < 5)
Gene RIFs: 236   (req: <= 3)
Antibodies: 590   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1081.17   (req: >= 5)
Gene RIFs: 236   (req: > 3)
Antibodies: 590   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 65
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 161
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
valosin containing protein
VGNC:4900
747490
Macaque
valosin containing protein
698707
Mouse
MGI:99919
269523
Rat
RGD:621595
116643
Dog
valosin containing protein
VGNC:48243
481590
Species
Name
OMA
EggNOG
Inparanoid
Chimp
valosin containing protein
Macaque
valosin containing protein
Mouse
Rat
Dog
valosin containing protein
Protein Structure (34 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P55072-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 34
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (36)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 33
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
Asparagine N-linked glycosylation
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
Asparagine N-linked glycosylation
Cellular response to heat stress
Cellular responses to external stimuli
Gene Ontology Terms (89)
Items per page:
10
1 – 10 of 16
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (529)
1 – 10 of 529
UBXN2A
Tbio
Novelty: 0.52282698
p_int: 0.999999998
p_ni: 2e-9
Score: 0.938
Data Source: BioPlex,STRINGDB
UBXN6
Tbio
Novelty: 0.08383376
p_int: 0.999999971
p_ni: 2.9e-8
Score: 0.996
Data Source: BioPlex,STRINGDB
ASPSCR1
Tbio
Novelty: 0.01172319
p_int: 0.999998734
p_ni: 0.000001265
Score: 0.965
Data Source: BioPlex,STRINGDB
NSFL1C
Tbio
Novelty: 0.05494848
p_int: 0.999983546
p_ni: 0.000016454
Score: 0.999
Data Source: BioPlex,STRINGDB
UBL7
Tdark
Novelty: 0.20935024
p_int: 0.999579606
p_ni: 0.000420394
Score: 0.676
Data Source: BioPlex,STRINGDB
UBE4B
Tbio
Novelty: 0.01396546
p_int: 0.99932512
p_ni: 0.00067488
Score: 0.992
Data Source: BioPlex,STRINGDB
UBXN2B
Tbio
Novelty: 0.67291382
p_int: 0.998350087
p_ni: 0.001649913
Score: 0.882
Data Source: BioPlex,STRINGDB
FAM104A
Tdark
Novelty: 0.81293501
p_int: 0.994359871
p_ni: 0.000001011
p_wrong: 0.005639117
Score: 0.852
Data Source: BioPlex,STRINGDB
VCPKMT
Tbio
Family: Enzyme
Novelty: 0.37849297
p_int: 0.991912202
p_ni: 9.5e-8
p_wrong: 0.008087703
Score: 0.996
Data Source: BioPlex,Reactome,STRINGDB
PRKN
Tbio
Family: Enzyme
Novelty: 0.00079898
p_int: 0.976711077
p_ni: 0.023288923
Score: 0.624
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  1081.17

PubMed score by year
PubTator Score  524.18

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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