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Tbio
AQP5
Aquaporin-5

Protein Summary
Description
Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions. Required for TRPV4 activation by hypotonicity (PubMed:16571723). Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells (PubMed:16571723). Aquaporin 5 (AQP5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary secretions. AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293599
  • ENSP00000293599
  • ENSG00000161798

Symbol
  • PPKB
  • AQP-5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.99
cellular component
0.77
gene perturbation
0.77
molecular function
0.67
kinase perturbation
0.66


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 567.14   (req: < 5)
Gene RIFs: 101   (req: <= 3)
Antibodies: 290   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 567.14   (req: >= 5)
Gene RIFs: 101   (req: > 3)
Antibodies: 290   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aquaporin 5
VGNC:4929
741283
Mouse
MGI:106215
11830
Rat
RGD:2144
25241
Cow
aquaporin 5
VGNC:26048
782368
Pig
aquaporin 5
100126278
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aquaporin 5
Mouse
Rat
Cow
aquaporin 5
Pig
aquaporin 5
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P55064-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Aquaporin-mediated transport (R-HSA-445717)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aquaporin-mediated transport
Reactome
Passive transport by Aquaporins
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Aquaporin-mediated transport
Passive transport by Aquaporins
Transport of small molecules
Gene Ontology Terms (17)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Protein-Protein Interactions (53)
1 – 10 of 53
STX4
Tbio
Novelty: 0.00831588
Score: 0.919
Data Source: STRINGDB
EXOC4
Tbio
Novelty: 0.01636648
Score: 0.906
Data Source: STRINGDB
EXOC3
Tbio
Novelty: 0.01051955
Score: 0.902
Data Source: STRINGDB
AQP10
Tbio
Novelty: 0.03507619
Score: 0.882
Data Source: STRINGDB
AQP12A
Tbio
Novelty: 0.04258853
Score: 0.846
Data Source: STRINGDB
AQP11
Tbio
Novelty: 0.0229197
Score: 0.814
Data Source: STRINGDB
SFTPC
Tbio
Novelty: 0.00154396
Score: 0.773
Data Source: STRINGDB
TRPV4
Tchem
Family: IC
Novelty: 0.00111193
Score: 0.758
Data Source: STRINGDB
SCGB1A1
Tbio
Novelty: 0.00100772
Score: 0.692
Data Source: STRINGDB
SFTPA1
Tbio
Novelty: 0.00530837
Score: 0.663
Data Source: STRINGDB
Publication Statistics
PubMed Score  567.14

PubMed score by year
PubTator Score  235.86

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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