Tbio AQP5 Aquaporin-5

Protein Classes

PANTHER Classes

Protein / Transporter / Aquaporin-5

DTO Classes

Protein / Ion Channel / Other Ion Channel / Aquaporin / Aquaporin-5

Protein Summary

Description

Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions. Required for TRPV4 activation by hypotonicity (PubMed:16571723). Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells (PubMed:16571723). Aquaporin 5 (AQP5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary secretions. AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P55064
• Q6FGW8
• AQP-5

Gene Name

• AQP5

Ensembl ID

• ENST00000293599
• ENSP00000293599
• ENSG00000161798

Symbol

• PPKB
• AQP-5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.99
cellular component	0.77
gene perturbation	0.77
molecular function	0.67
kinase perturbation	0.66

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 511.22   (req: < 5)

Gene RIFs: 101   (req: <= 3)

Antibodies: 290   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 511.22   (req: >= 5)

Gene RIFs: 101   (req: > 3)

Antibodies: 290   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (3)

1 – 3 of 3

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (5)

Reactome (3)

KEGG (1)

PathwayCommons (1)

Aquaporin-mediated transport (R-HSA-445717)

Click on a row in the table to change the structure displayed.

Items per page:

5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Aquaporin-mediated transport	55 targets	R-HSA-445717
Reactome	Passive transport by Aquaporins	13 targets	R-HSA-432047
Reactome	Transport of small molecules	725 targets	R-HSA-382551

Name	Explore in Pharos	Explore in Source
Aquaporin-mediated transport	55 targets	R-HSA-445717
Passive transport by Aquaporins	13 targets	R-HSA-432047
Transport of small molecules	725 targets	R-HSA-382551

Gene Ontology Terms (17)

Functions (2)

Components (8)

Processes (7)

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
water channel activity	Inferred from Direct Assay (IDA)	UniProtKB
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct

Protein-Protein Interactions (53)

Explore Interacting Targets

1 – 10 of 53

• See Interactions on String-DB

STX4

Tbio

Novelty: 0.01072491

Score: 0.919

Data Source: STRINGDB

EXOC4

Tbio

Novelty: 0.02000189

Score: 0.906

Data Source: STRINGDB

EXOC3

Tbio

Novelty: 0.01423005

Score: 0.902

Data Source: STRINGDB

AQP10

Tbio

Novelty: 0.05001269

Score: 0.882

Data Source: STRINGDB

AQP12A

Tbio

Novelty: 0.0840303

Score: 0.846

Data Source: STRINGDB

AQP11

Tbio

Novelty: 0.02650569

Score: 0.814

Data Source: STRINGDB

SFTPC

Tbio

Novelty: 0.00174879

Score: 0.773

Data Source: STRINGDB

TRPV4

Tchem

Family: IC

Novelty: 0.00123393

Score: 0.758

Data Source: STRINGDB

SCGB1A1

Tbio

Novelty: 0.00118669

Score: 0.692

Data Source: STRINGDB

SFTPA1

Tbio

Novelty: 0.00575742

Score: 0.663

Data Source: STRINGDB

Publication Statistics

PubMed Score  511.22

PubMed score by year

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PubTator Score  235.86

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MKKEVCSVAFLKAVFAEFLATLIFVFFGLGSALKWPSALPTILQIALAFGLAIGTLAQALGPVSGGHINP

1-70

AITLALLVGNQISLLRAFFYVAAQLVGAIAGAGILYGVAPLNARGNLAVNALNNNTTQGQAMVVELILTF

70-140

QLALCIFASTDSRRTSPVGSPALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFSPAHWVFWVGP

140-210

IVGAVLAAILYFYLLFPNSLSLSERVAIIKGTYEPDEDWEEQREERKKTMELTTR

210-265

MKKEVCSVAFLKAVFAEFLATLIFVFFGLGSALKWPSALPTILQIALAFGLAIGTLAQALGPVSGGHINPAITLALLVGNQISLLRAFFYVAAQLVGAIAGAGILYGVAPLNARGNLAVNALNNNTTQGQAMVVELILTFQLALCIFASTDSRRTSPVGSPALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFSPAHWVFWVGPIVGAVLAAILYFYLLFPNSLSLSERVAIIKGTYEPDEDWEEQREERKKTMELTTR

Find similar targets by:

Uniprot Keyword

3D-structure
Cell membrane
Complete proteome
Disease mutation
Glycoprotein
Membrane
Palmoplantar keratoderma
Reference proteome
Repeat
Transmembrane