Tbio AQP5 Aquaporin-5

Protein Classes

PANTHER Classes

Protein / Transporter / Aquaporin-5

DTO Classes

Protein / Ion Channel / Other Ion Channel / Aquaporin / Aquaporin-5

Protein Summary

Description

Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions. Required for TRPV4 activation by hypotonicity (PubMed:16571723). Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells (PubMed:16571723). Aquaporin 5 (AQP5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary secretions. AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P55064
• Q6FGW8
• AQP-5

Gene Name

• AQP5

Ensembl ID

• ENST00000293599
• ENSP00000293599
• ENSG00000161798

Symbol

• PPKB
• AQP-5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.99
cellular component	0.77
gene perturbation	0.77
molecular function	0.67
kinase perturbation	0.66

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 567.14   (req: < 5)

Gene RIFs: 101   (req: <= 3)

Antibodies: 290   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 567.14   (req: >= 5)

Gene RIFs: 101   (req: > 3)

Antibodies: 290   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (6)

1 – 5 of 6

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	aquaporin 5	VGNC:4929	741283
Mouse	aquaporin 5	MGI:106215	11830
Rat	aquaporin 5	RGD:2144	25241
Cow	aquaporin 5	VGNC:26048	782368
Pig	aquaporin 5		100126278

Species	Name	OMA	EggNOG	Inparanoid
Chimp	aquaporin 5
Mouse	aquaporin 5
Rat	aquaporin 5
Cow	aquaporin 5
Pig	aquaporin 5

Protein Structure (3 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P55064-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (5)

Reactome (3)

KEGG (1)

PathwayCommons (1)

Aquaporin-mediated transport (R-HSA-445717)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Aquaporin-mediated transport	55 targets	R-HSA-445717
Reactome	Passive transport by Aquaporins	13 targets	R-HSA-432047
Reactome	Transport of small molecules	725 targets	R-HSA-382551

Name	Explore in Pharos	Explore in Source
Aquaporin-mediated transport	55 targets	R-HSA-445717
Passive transport by Aquaporins	13 targets	R-HSA-432047
Transport of small molecules	725 targets	R-HSA-382551

Gene Ontology Terms (17)

Functions (2)

Components (8)

Processes (7)

Find Similar Targets

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
water channel activity	Inferred from Direct Assay (IDA)	UniProtKB
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct

Protein-Protein Interactions (53)

Explore Interacting Targets

1 – 10 of 53

• See Interactions on String-DB

STX4

Tbio

Novelty: 0.00831588

Score: 0.919

Data Source: STRINGDB

EXOC4

Tbio

Novelty: 0.01636648

Score: 0.906

Data Source: STRINGDB

EXOC3

Tbio

Novelty: 0.01051955

Score: 0.902

Data Source: STRINGDB

AQP10

Tbio

Novelty: 0.03507619

Score: 0.882

Data Source: STRINGDB

AQP12A

Tbio

Novelty: 0.04258853

Score: 0.846

Data Source: STRINGDB

AQP11

Tbio

Novelty: 0.0229197

Score: 0.814

Data Source: STRINGDB

SFTPC

Tbio

Novelty: 0.00154396

Score: 0.773

Data Source: STRINGDB

TRPV4

Tchem

Family: IC

Novelty: 0.00111193

Score: 0.758

Data Source: STRINGDB

SCGB1A1

Tbio

Novelty: 0.00100772

Score: 0.692

Data Source: STRINGDB

SFTPA1

Tbio

Novelty: 0.00530837

Score: 0.663

Data Source: STRINGDB

Publication Statistics

PubMed Score  567.14

PubMed score by year

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PubTator Score  235.86

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

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Find similar targets by:

UniProt Keyword Find Similar Targets

3D-structure
Cell membrane
Complete proteome
Disease mutation
Glycoprotein
Membrane
Palmoplantar keratoderma
Reference proteome
Repeat
Transmembrane

MGI Phenotype Find Similar Targets

digestive/alimentary phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
mortality/aging
respiratory system phenotype