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Tbio
AQP5
Aquaporin-5

Protein Summary
Description
Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions. Required for TRPV4 activation by hypotonicity (PubMed:16571723). Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells (PubMed:16571723). Aquaporin 5 (AQP5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary secretions. AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293599
  • ENSP00000293599
  • ENSG00000161798

Symbol
  • PPKB
  • AQP-5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.99
cellular component
0.77
gene perturbation
0.77
molecular function
0.67
kinase perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 586.87   (req: < 5)
Gene RIFs: 101   (req: <= 3)
Antibodies: 290   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 586.87   (req: >= 5)
Gene RIFs: 101   (req: > 3)
Antibodies: 290   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (53)
STX4
Tbio
Novelty:  0.00831588
Score:  0.919
Data Source:  STRINGDB
EXOC4
Tbio
Novelty:  0.01636648
Score:  0.906
Data Source:  STRINGDB
EXOC3
Tbio
Novelty:  0.01051955
Score:  0.902
Data Source:  STRINGDB
AQP10
Tbio
Novelty:  0.03507619
Score:  0.882
Data Source:  STRINGDB
AQP12A
Tbio
Novelty:  0.04258853
Score:  0.846
Data Source:  STRINGDB
AQP11
Tbio
Novelty:  0.0229197
Score:  0.814
Data Source:  STRINGDB
SFTPC
Tbio
Novelty:  0.00154396
Score:  0.773
Data Source:  STRINGDB
TRPV4
Tchem
Family:  IC
Novelty:  0.00111193
Score:  0.758
Data Source:  STRINGDB
SCGB1A1
Tbio
Novelty:  0.00100772
Score:  0.692
Data Source:  STRINGDB
SFTPA1
Tbio
Novelty:  0.00530837
Score:  0.663
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Aquaporin-mediated transport (R-HSA-445717)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aquaporin-mediated transport
Reactome
Passive transport by Aquaporins
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Aquaporin-mediated transport
Passive transport by Aquaporins
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
2
3
93.8
comparative body size at age 10, self-reported
1
1
1
87.3
body height
1
1
1
82.4
obese body mass index status
2
1
0
1.2
80.3
visceral adipose tissue measurement
1
1
1
75.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
93.8
comparative body size at age 10, self-reported
1
87.3
body height
1
82.4
obese body mass index status
0
1.2
80.3
visceral adipose tissue measurement
1
75.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aquaporin 5
VGNC:4929
741283
Mouse
MGI:106215
11830
Rat
RGD:2144
25241
Cow
aquaporin 5
VGNC:26048
782368
Pig
aquaporin 5
100126278
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aquaporin 5
Mouse
Rat
Cow
aquaporin 5
Pig
aquaporin 5
Publication Statistics
PubMed Score 586.87
PubMed score by year
PubTator Score 235.86
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title