Protein Summary
Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions. Required for TRPV4 activation by hypotonicity (PubMed:16571723). Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells (PubMed:16571723). Aquaporin 5 (AQP5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary secretions. AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13. [provided by RefSeq, Jul 2008]
- ENST00000293599
- ENSP00000293599
- ENSG00000161798
- PPKB
- AQP-5
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
co-expressed gene | 0.99 | ||
cellular component | 0.77 | ||
gene perturbation | 0.77 | ||
molecular function | 0.67 | ||
kinase perturbation | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 586.87 (req: < 5)
Gene RIFs: 101 (req: <= 3)
Antibodies: 290 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 586.87 (req: >= 5)
Gene RIFs: 101 (req: > 3)
Antibodies: 290 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (53)
Nearest Tclin Targets
Pathways (5)
Reactome (3)
KEGG (1)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Aquaporin-mediated transport | ||||
Reactome | Passive transport by Aquaporins | ||||
Reactome | Transport of small molecules | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Aquaporin-mediated transport | ||||
Passive transport by Aquaporins | ||||
Transport of small molecules | ||||
Viral Interactions (0)
Gene Ontology Terms (17)
Functions (2)
Components (8)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Disease Associations ()
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
body mass index | 3 | 2 | 3 | 93.8 | |||||
comparative body size at age 10, self-reported | 1 | 1 | 1 | 87.3 | |||||
body height | 1 | 1 | 1 | 82.4 | |||||
obese body mass index status | 2 | 1 | 0 | 1.2 | 80.3 | ||||
visceral adipose tissue measurement | 1 | 1 | 1 | 75.9 | |||||
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
body mass index | 3 | 93.8 | |||||
comparative body size at age 10, self-reported | 1 | 87.3 | |||||
body height | 1 | 82.4 | |||||
obese body mass index status | 0 | 1.2 | 80.3 | ||||
visceral adipose tissue measurement | 1 | 75.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (6)
1 – 5 of 6
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | aquaporin 5 | VGNC:4929 | 741283 | |||||
Mouse | MGI:106215 | 11830 | ||||||
Rat | RGD:2144 | 25241 | ||||||
Cow | aquaporin 5 | VGNC:26048 | 782368 | |||||
Pig | aquaporin 5 | 100126278 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | aquaporin 5 | |||||
Mouse | ||||||
Rat | ||||||
Cow | aquaporin 5 | |||||
Pig | aquaporin 5 | |||||
Publication Statistics
PubMed Score 586.87
PubMed score by year
PubTator Score 235.86
PubTator score by year
Related Publications
Text Mined References (143)
GeneRif Annotations (101)
Items per page:
0 of 0
PMID | Year | Title |
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