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Tbio
TMBIM6
Bax inhibitor 1

Protein Summary
Description
Suppressor of apoptosis (PubMed:21075086). Modulates unfolded protein response signaling (PubMed:21075086). Modulates ER calcium homeostasis by acting as a calcium-leak channel (PubMed:22128171). Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267115
  • ENSP00000267115
  • ENSG00000139644
  • ENST00000395006
  • ENSP00000378454
  • ENST00000423828
  • ENSP00000389277
  • ENST00000549385
  • ENSP00000448036
  • ENST00000552370
  • ENSP00000450158
  • ENST00000552699
  • ENSP00000446734

Symbol
  • BI1
  • TEGT
  • BI-1
  • TEGT
  • BAXI1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
transcription factor binding site profile
0.93
co-expressed gene
0.87
disease perturbation
0.83
transcription factor perturbation
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 716.72   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 203   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 716.72   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 203   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
80.8
anthropometric measurement
1
2
0
1.1
74.9
age at menarche
2
2
2
56
body mass index
14
1
24
1.1
40.5
intelligence
2
2
1
5.5
39.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
80.8
anthropometric measurement
0
1.1
74.9
age at menarche
2
56
body mass index
24
1.1
40.5
intelligence
1
5.5
39.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane BAX inhibitor motif containing 6
VGNC:8576
451883
Macaque
transmembrane BAX inhibitor motif containing 6
677702
Mouse
MGI:99682
110213
Dog
transmembrane BAX inhibitor motif containing 6
VGNC:47419
477614
Horse
transmembrane BAX inhibitor motif containing 6
VGNC:24152
100052024
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane BAX inhibitor motif containing 6
Macaque
transmembrane BAX inhibitor motif containing 6
Mouse
Dog
transmembrane BAX inhibitor motif containing 6
Horse
transmembrane BAX inhibitor motif containing 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P55061-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (26)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Protein-Protein Interactions (70)
1 – 10 of 70
CLEC5A
Tbio
Novelty:  0.01710591
p_int:  0.998723362
p_ni:  0.001276615
p_wrong:  2.4e-8
Score:  0.183
Data Source:  BioPlex,STRINGDB
DUSP3
Tchem
Family:  Enzyme
Novelty:  0.00518547
p_int:  0.996118158
p_ni:  0.003880719
p_wrong:  0.000001123
Data Source:  BioPlex
ADAM33
Tchem
Family:  Enzyme
Novelty:  0.00584097
p_int:  0.955631074
p_ni:  0.044368549
p_wrong:  3.78e-7
Data Source:  BioPlex
KIAA2013
Tdark
Novelty:  0.4705158
p_int:  0.936661754
p_ni:  0.063337086
p_wrong:  0.00000116
Data Source:  BioPlex
PCDHA8
Tdark
Novelty:  0.57189179
p_int:  0.930511931
p_ni:  0.061446926
p_wrong:  0.008041144
Data Source:  BioPlex
ODF4
Tbio
Novelty:  0.13423621
p_int:  0.901175304
p_ni:  0.098824685
p_wrong:  1.1e-8
Score:  0.189
Data Source:  BioPlex,STRINGDB
POMK
Tbio
Family:  Kinase
Novelty:  0.09340344
p_int:  0.887244591
p_ni:  0.112755402
p_wrong:  7e-9
Data Source:  BioPlex
ASIC4
Tbio
Family:  IC
Novelty:  0.02912816
p_int:  0.882256999
p_ni:  0.117610551
p_wrong:  0.00013245
Data Source:  BioPlex
SPPL2B
Tchem
Family:  Enzyme
Novelty:  0.0274774
p_int:  0.877615442
p_ni:  0.122384547
p_wrong:  1.1e-8
Data Source:  BioPlex
RNF185
Tbio
Family:  Enzyme
Novelty:  0.23911257
p_int:  0.860949479
p_ni:  0.139050521
Score:  0.236
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  716.72

PubMed score by year
PubTator Score  151.3

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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