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Tbio
CSE1L
Exportin-2

Protein Summary
Description
Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/b ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
protein complex
0.99
hub protein
0.98
disease perturbation
0.95
kinase perturbation
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.88   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 476   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.88   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 476   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein-Protein Interactions (162)
1 – 10 of 162
TMEM206
Tdark
Novelty: 0.38095238
p_int: 0.892775588
p_ni: 0.107224412
Score: 0.189
Data Source: BioPlex,STRINGDB
CYB5B
Tbio
Novelty: 0.11412954
p_int: 0.861537385
p_ni: 0.138462615
Score: 0.44
Data Source: BioPlex,STRINGDB
TPST2
Tbio
Family: Enzyme
Novelty: 0.03075981
p_int: 0.751129001
p_ni: 0.248870999
Data Source: BioPlex
CDC5L
Tbio
Family: TF
Novelty: 0.00617757
Score: 0.987
Data Source: STRINGDB
KPNA2
Tbio
Novelty: 0.00784264
Score: 0.932
Data Source: STRINGDB
KPNA1
Tbio
Novelty: 0.0115908
Score: 0.915
Data Source: STRINGDB
KPNB1
Tbio
Novelty: 0.02119848
Score: 0.914
Data Source: STRINGDB
XPO1
Tclin
Novelty: 0.00065429
Score: 0.909
Data Source: STRINGDB
KPNA4
Tbio
Novelty: 0.02255219
Score: 0.894
Data Source: STRINGDB
IPO5
Tbio
Novelty: 0.00618638
Score: 0.889
Data Source: STRINGDB
Publication Statistics
PubMed Score  105.88

PubMed score by year
PubTator Score  188.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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