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Tbio
PLTP
Phospholipid transfer protein

Protein Summary
Description
Facilitates the transfer of a spectrum of different lipid molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylglycerol, cerebroside and phosphatidyl ethanolamine. Essential for the transfer of excess surface lipids from triglyceride-rich lipoproteins to HDL, thereby facilitating the formation of smaller lipoprotein remnants, contributing to the formation of LDL, and assisting in the maturation of HDL particles. PLTP also plays a key role in the uptake of cholesterol from peripheral cells and tissues that is subsequently transported to the liver for degradation and excretion. Two distinct forms of PLTP exist in plasma: an active form that can transfer PC from phospholipid vesicles to high-density lipoproteins (HDL), and an inactive form that lacks this capability. The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. The encoded protein transfers phospholipids from triglyceride-rich lipo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354050
  • ENSP00000335290
  • ENSG00000100979
  • ENST00000372420
  • ENSP00000361497
  • ENST00000372431
  • ENSP00000361508
  • ENST00000420868
  • ENSP00000411671
  • ENST00000477313
  • ENSP00000417138

Symbol
  • BPIFE
  • HDLCQ9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
0.98
PubMedID
0.93
disease perturbation
0.83
gene perturbation
0.78
protein domain
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 433.75   (req: < 5)
Gene RIFs: 88   (req: <= 3)
Antibodies: 292   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 433.75   (req: >= 5)
Gene RIFs: 88   (req: > 3)
Antibodies: 292   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (124)
FAM19A5
Tdark
Novelty:  0.07792418
p_int:  0.998676498
p_ni:  0.001323501
Data Source:  BioPlex
SEL1L3
Tdark
Novelty:  0.62775736
p_int:  0.998151205
p_ni:  0.001848795
Score:  0.768
Data Source:  BioPlex,STRINGDB
UGT8
Tbio
Family:  Enzyme
Novelty:  0.02518383
p_int:  0.997317341
p_ni:  0.002682659
Data Source:  BioPlex
EPB41L5
Tbio
Novelty:  0.0391959
p_int:  0.996794686
p_ni:  0.003205314
Data Source:  BioPlex
SIAE
Tbio
Family:  Enzyme
Novelty:  0.01138067
p_int:  0.996188972
p_ni:  0.003810909
p_wrong:  1.2e-7
Score:  0.165
Data Source:  BioPlex,STRINGDB
ADPGK
Tbio
Family:  Kinase
Novelty:  0.0552414
p_int:  0.995348197
p_ni:  0.004651803
Score:  0.241
Data Source:  BioPlex,STRINGDB
DDX31
Tbio
Family:  Enzyme
Novelty:  2.84646195
p_int:  0.993169723
p_ni:  0.006830276
p_wrong:  1e-9
Data Source:  BioPlex
DHFR2
Tbio
Family:  Enzyme
Novelty:  0.02374466
p_int:  0.992480091
p_ni:  0.007511934
p_wrong:  0.000007976
Score:  0.209
Data Source:  BioPlex,STRINGDB
HYOU1
Tbio
Novelty:  0.00833649
p_int:  0.988445447
p_ni:  0.011543866
p_wrong:  0.000010686
Data Source:  BioPlex
SCGB2A1
Tbio
Novelty:  0.01902973
p_int:  0.982776434
p_ni:  0.017212252
p_wrong:  0.000011313
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (37)
HDL remodeling (R-HSA-8964058)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
HDL remodeling
Reactome
Plasma lipoprotein assembly, remodeling, and clearance
Reactome
Plasma lipoprotein remodeling
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
HDL remodeling
Plasma lipoprotein assembly, remodeling, and clearance
Plasma lipoprotein remodeling
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (23)
Find Similar Targets
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Disease Associations ()
No disease associations found
GWAS Traits (33)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
15
15
26
99.7
triglyceride measurement
14
12
24
3.3
99.4
sleep duration
4
3
4
90.1
apolipoprotein B measurement
2
2
2
86.8
blood metabolite measurement
1
2
2
86
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
26
99.7
triglyceride measurement
24
3.3
99.4
sleep duration
4
90.1
apolipoprotein B measurement
2
86.8
blood metabolite measurement
2
86
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phospholipid transfer protein
VGNC:6245
458291
Macaque
phospholipid transfer protein
708711
Mouse
MGI:103151
18830
Rat
RGD:1306695
296371
Dog
phospholipid transfer protein
VGNC:44714
485903
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phospholipid transfer protein
Macaque
phospholipid transfer protein
Mouse
Rat
Dog
phospholipid transfer protein
Publication Statistics
PubMed Score 433.75
PubMed score by year
PubTator Score 193.35
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title