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Tbio
APOC4
Apolipoprotein C-IV

Protein Summary
Description
May participate in lipoprotein metabolism. This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is thought to play a role in lipid metabolism. Polymorphisms in this gene may influence circulating lipid levels and may be associated with coronary artery disease risk. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring downstream apolipoprotein C-II (APOC2) gene. [provided by RefSeq, Mar 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000592954
  • ENSP00000468236
  • ENSG00000267467

Symbol
  • APO-CIV
  • APOC-IV
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
gene perturbation
0.71
cell type or tissue
0.7
small molecule perturbation
0.58
co-expressed gene
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.44   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 110   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.44   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (45)
TRIM68
Tbio
Family:  Enzyme
Novelty:  0.11729189
p_int:  0.98721137
p_ni:  0.012788625
p_wrong:  5e-9
Data Source:  BioPlex
TMEM259
Tbio
Novelty:  0.10015777
p_int:  0.955428517
p_ni:  0.044571482
p_wrong:  1e-9
Data Source:  BioPlex
APOC1
Tbio
Novelty:  0.00338935
Score:  0.954
Data Source:  Reactome,STRINGDB
APOC2
Tbio
Novelty:  0.0015496
Score:  0.917
Data Source:  STRINGDB
APOB
Tchem
Novelty:  0.00008247
Score:  0.91
Data Source:  STRINGDB
LSR
Tbio
Novelty:  0.00528058
Score:  0.902
Data Source:  Reactome,STRINGDB
VLDLR
Tbio
Novelty:  0.00352547
Score:  0.9
Data Source:  Reactome,STRINGDB
APOBR
Tbio
Novelty:  0.06449114
Score:  0.9
Data Source:  Reactome,STRINGDB
APOC3
Tclin
Novelty:  0.0009635
Score:  0.872
Data Source:  STRINGDB
APOA4
Tbio
Novelty:  0.00305835
Score:  0.836
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Plasma lipoprotein assembly (R-HSA-8963898)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Plasma lipoprotein assembly
Reactome
Plasma lipoprotein assembly, remodeling, and clearance
Reactome
Plasma lipoprotein clearance
Reactome
Transport of small molecules
Reactome
VLDL assembly
Name
Explore in Pharos
Explore in Source
Plasma lipoprotein assembly
Plasma lipoprotein assembly, remodeling, and clearance
Plasma lipoprotein clearance
Transport of small molecules
VLDL assembly
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (119)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
34
71
108
8
100
apolipoprotein B measurement
2
62
63
100
total cholesterol measurement
21
61
89
6.8
100
C-reactive protein measurement
14
56
72
21.8
100
27
57
2
2.8
99.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
108
8
100
apolipoprotein B measurement
63
100
total cholesterol measurement
89
6.8
100
C-reactive protein measurement
72
21.8
100
2
2.8
99.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
apolipoprotein C4
VGNC:10194
744510
Mouse
MGI:87878
11425
Rat
RGD:70959
680551
Dog
apolipoprotein C4
VGNC:53523
111097895
Horse
apolipoprotein C4
VGNC:50995
100065506
Species
Name
OMA
EggNOG
Inparanoid
Chimp
apolipoprotein C4
Mouse
Rat
Dog
apolipoprotein C4
Horse
apolipoprotein C4
Publication Statistics
PubMed Score 14.44
PubMed score by year
PubTator Score 9.67
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title