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Tchem
NR1H2
Oxysterols receptor LXR-beta

Protein Summary
Description
Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920). Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957). The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, i ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253727
  • ENSP00000253727
  • ENSG00000131408
  • ENST00000411902
  • ENSP00000396151
  • ENST00000593926
  • ENSP00000471194

Symbol
  • LXRB
  • NER
  • UNR
  • NER
  • UNR
  • LXRB
  • LXR-b
  • NER-I
  • RIP15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
biological process
0.99
kinase perturbation
0.88
protein domain
0.85
transcription factor binding site profile
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.57   (req: < 5)
Gene RIFs: 106   (req: <= 3)
Antibodies: 364   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.57   (req: >= 5)
Gene RIFs: 106   (req: > 3)
Antibodies: 364   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 45
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 326
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (17)
1 – 5 of 17
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (22)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism
Metabolism of lipids
Metabolism of proteins
Gene Ontology Terms (49)
Items per page:
10
1 – 10 of 15
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Protein-Protein Interactions (84)
1 – 10 of 84
RXRG
Tclin
Family: NR
Novelty: 0.01646377
p_int: 1
Score: 0.992
Data Source: BioPlex,STRINGDB
ABCA1
Tclin
Family: Transporter
Novelty: 0.00059241
Score: 0.989
Data Source: Reactome,STRINGDB
NCOR1
Tchem
Family: TF
Novelty: 0.0021926
Score: 0.987
Data Source: Reactome,STRINGDB
NCOR2
Tchem
Family: TF
Novelty: 0.00066449
Score: 0.987
Data Source: Reactome,STRINGDB
RXRB
Tclin
Family: NR
Novelty: 0.01503977
Score: 0.987
Data Source: STRINGDB
RXRA
Tclin
Family: NR
Novelty: 0.00244343
Score: 0.985
Data Source: Reactome,STRINGDB
MED1
Tbio
Family: Enzyme
Novelty: 0.00852082
Score: 0.949
Data Source: STRINGDB
HDAC4
Tclin
Family: Epigenetic
Novelty: 0.00217749
Score: 0.937
Data Source: STRINGDB
UBE2I
Tbio
Novelty: 0.00267883
Score: 0.919
Data Source: Reactome,STRINGDB
VLDLR
Tbio
Novelty: 0.00352547
Score: 0.916
Data Source: STRINGDB
Publication Statistics
PubMed Score  65.57

PubMed score by year
PubTator Score  156.36

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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