You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
NR1H2
Oxysterols receptor LXR-beta

Protein Summary
Description
Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920). Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957). The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, i ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253727
  • ENSP00000253727
  • ENSG00000131408
  • ENST00000411902
  • ENSP00000396151
  • ENST00000593926
  • ENSP00000471194

Symbol
  • LXRB
  • NER
  • UNR
  • NER
  • UNR
  • LXRB
  • LXR-b
  • NER-I
  • RIP15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
biological process
0.99
kinase perturbation
0.88
protein domain
0.85
transcription factor binding site profile
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75   (req: < 5)
Gene RIFs: 106   (req: <= 3)
Antibodies: 364   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75   (req: >= 5)
Gene RIFs: 106   (req: > 3)
Antibodies: 364   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 45
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 358
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0