Tbio RRAD GTP-binding protein RAD

Protein Summary

Description

May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D.

Uniprot Accession IDs

• P55042
• Q96F39

Gene Name

• RRAD

Ensembl ID

• ENST00000299759
• ENSP00000299759
• ENSG00000166592
• ENST00000420652
• ENSP00000388744

Symbol

• RAD
• RAD
• RAD1
• REM3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.99
molecular function	0.93
PubMedID	0.87
protein domain	0.85
virus perturbation	0.83

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 367.98   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 156   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 367.98   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (41)

Explore Interacting Targets

1 – 10 of 41

• See Interactions on String-DB

TP53

Tchem

Family:  TF

Novelty:  0.00001907

Score:  0.721

Data Source:  STRINGDB

ERCC6

Tbio

Novelty:  0.00764502

Score:  0.659

Data Source:  STRINGDB

RAPGEFL1

Tdark

Novelty:  1.01382041

Score:  0.649

Data Source:  STRINGDB

NR4A3

Tbio

Family:  NR

Novelty:  0.00882077

Score:  0.589

Data Source:  STRINGDB

XPC

Tbio

Novelty:  0.00775175

Score:  0.588

Data Source:  STRINGDB

EHF

Tbio

Family:  TF

Novelty:  0.00990018

Score:  0.533

Data Source:  STRINGDB

KNDC1

Tdark

Novelty:  0.1459108

Score:  0.53

Data Source:  STRINGDB

GP5

Tbio

Novelty:  0.00095584

Score:  0.529

Data Source:  STRINGDB

TLR3

Tbio

Novelty:  0.00057048

Score:  0.524

Data Source:  STRINGDB

UQCRC1

Tbio

Family:  Enzyme

Novelty:  0.01746759

Score:  0.518

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (34)

PathwayCommons (1)

WikiPathways (33)

Find Similar Targets

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5

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Data Source	Name	Explore in Pharos	Explore in Source
PathwayCommons: pid	Validated transcriptional targets of deltaNp63 isoforms	48 targets	PathwayCommons: pid

Name	Explore in Pharos	Explore in Source
Validated transcriptional targets of deltaNp63 isoforms	48 targets	PathwayCommons: pid

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (6)

Functions (3)

Components (1)

Processes (2)

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10

1 – 3 of 3

GO Term	Evidence	Assigned by
GTP binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
GTPase activity	Traceable Author Statement (TAS)	ProtInc
calmodulin binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (9)

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5

1 – 5 of 9

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
apolipoprotein A 1 measurement	EFO_0004614	2	4	4		87.9
high density lipoprotein cholesterol measurement	EFO_0004612	2	3	4		83.3
heel bone mineral density	EFO_0009270	2	2	2		80.6
diastolic blood pressure	EFO_0006336	1	1	1		73.7
blood protein measurement	EFO_0007937	1	1	1		58.4

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 9

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
apolipoprotein A 1 measurement	EFO_0004614	4		87.9
high density lipoprotein cholesterol measurement	EFO_0004612	4		83.3
heel bone mineral density	EFO_0009270	2		80.6
diastolic blood pressure	EFO_0006336	1		73.7
blood protein measurement	EFO_0007937	1		58.4

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Calmodulin-binding
Cell membrane
Complete proteome
GTP-binding
Membrane
Methylation
Nucleotide-binding
Phosphoprotein
Polymorphism

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein A 1 measurement
blood protein measurement
BMI-adjusted waist circumference
diastolic blood pressure
heel bone mineral density
high density lipoprotein cholesterol measurement
leukocyte count
monocyte count
myeloid white cell count

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
homeostasis/metabolism phenotype
muscle phenotype

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	RRAD, Ras related glycolysis inhibitor and calcium channel regulator	VGNC:10500	741038
Mouse	Ras-related associated with diabetes	MGI:1930943	56437
Rat	RRAD, Ras related glycolysis inhibitor and calcium channel regulator	RGD:69357	83521
Dog	RRAD, Ras related glycolysis inhibitor and calcium channel regulator	VGNC:45755	611304
Horse	RRAD, Ras related glycolysis inhibitor and calcium channel regulator	VGNC:22575	100065651

Species	Name	OMA	EggNOG	Inparanoid
Chimp	RRAD, Ras related glycolysis inhibitor and calcium channel regulator
Mouse	Ras-related associated with diabetes
Rat	RRAD, Ras related glycolysis inhibitor and calcium channel regulator
Dog	RRAD, Ras related glycolysis inhibitor and calcium channel regulator
Horse	RRAD, Ras related glycolysis inhibitor and calcium channel regulator

Publication Statistics

PubMed Score 367.98

PubMed score by year

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PubTator Score 528.47

PubTator score by year

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Related Publications

Text Mined References (37)

GeneRif Annotations (19)

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0 of 0

PMID	Year	Title