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Tclin
SLC12A3
Solute carrier family 12 member 3

Protein Summary
Description
Electroneutral sodium and chloride ion cotransporter. In kidney distal convoluted tubules, key mediator of sodium and chloride reabsorption (PubMed:21613606, PubMed:22009145). Receptor for the proinflammatory cytokine IL18. Contributes to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2. May act either independently of IL18R1, or in a complex with IL18R1 (By similarity). This gene encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartter's syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants en ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000438926
  • ENSP00000402152
  • ENSG00000070915
  • ENST00000563236
  • ENSP00000456149
  • ENST00000566786
  • ENSP00000457552

Symbol
  • NCC
  • TSC
  • NCC
  • TSC
  • NCCT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.7
molecular function
0.67
gene perturbation
0.62
protein domain
0.58
disease
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 486.54   (req: < 5)
Gene RIFs: 101   (req: <= 3)
Antibodies: 245   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 486.54   (req: >= 5)
Gene RIFs: 101   (req: > 3)
Antibodies: 245   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 13
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
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RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (13)
indapamide
Rendered image for indapamide
chlortalidone
Rendered image for chlortalidone
trichlormethiazide
Rendered image for trichlormethiazide
cyclothiazide
Rendered image for cyclothiazide
hydrochlorothiazide
Rendered image for hydrochlorothiazide
metolazone
Rendered image for metolazone
bendroflumethiazide
Rendered image for bendroflumethiazide
benzthiazide
Rendered image for benzthiazide
chlorothiazide
Rendered image for chlorothiazide
hydroflumethiazide
Rendered image for hydroflumethiazide
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (83)
WNK4
Tbio
Family:  Kinase
Novelty:  0.00795905
Score:  0.913
Data Source:  STRINGDB
STK39
Tchem
Family:  Kinase
Novelty:  0.00548476
Score:  0.872
Data Source:  STRINGDB
WNK1
Tchem
Family:  Kinase
Novelty:  0.00270535
Score:  0.858
Data Source:  STRINGDB
CLCNKB
Tchem
Family:  IC
Novelty:  0.00982208
Score:  0.81
Data Source:  STRINGDB
KCNJ1
Tchem
Family:  IC
Novelty:  0.0025066
Score:  0.807
Data Source:  STRINGDB
KLHL3
Tbio
Novelty:  0.04045086
Score:  0.786
Data Source:  STRINGDB
WNK3
Tchem
Family:  Kinase
Novelty:  0.03382701
Score:  0.76
Data Source:  STRINGDB
SCNN1B
Tclin
Family:  IC
Novelty:  0.01281284
Score:  0.727
Data Source:  STRINGDB
SLC9A3
Tclin
Family:  Transporter
Novelty:  0.00146466
Score:  0.689
Data Source:  STRINGDB
AQP2
Tbio
Novelty:  0.00088471
Score:  0.686
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Cation-coupled Chloride cotransporters (R-HSA-426117)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cation-coupled Chloride cotransporters
Reactome
Defective SLC12A3 causes Gitelman syndrome (GS)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Reactome
SLC transporter disorders
Name
Explore in Pharos
Explore in Source
Cation-coupled Chloride cotransporters
Defective SLC12A3 causes Gitelman syndrome (GS)
Disease
Disorders of transmembrane transporters
SLC transporter disorders
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (46)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
53
75
186
2.7
100
apolipoprotein A 1 measurement
2
27
27
100
sleep duration
4
17
25
99.9
total cholesterol measurement
13
26
44
2.5
99.4
apolipoprotein B measurement
2
7
7
99.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
186
2.7
100
apolipoprotein A 1 measurement
27
100
sleep duration
25
99.9
total cholesterol measurement
44
2.5
99.4
apolipoprotein B measurement
7
99.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 12 member 3
VGNC:9011
454108
Macaque
solute carrier family 12 member 3
703090
Mouse
MGI:108114
20497
Rat
RGD:3686
54300
Dog
solute carrier family 12 member 3
VGNC:46220
478118
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 12 member 3
Macaque
solute carrier family 12 member 3
Mouse
Rat
Dog
solute carrier family 12 member 3
Publication Statistics
PubMed Score 486.54
PubMed score by year
PubTator Score 319.66
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title