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Tclin
SLC12A2
Solute carrier family 12 member 2

Protein Summary
Description
Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume. The protein encoded by this gene mediates sodium and chloride transport and reabsorption. The encoded protein is a membrane protein and is important in maintaining proper ionic balance and cell volume. This protein is phosphorylated in response to DNA damage. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262461
  • ENSP00000262461
  • ENSG00000064651
  • ENST00000343225
  • ENSP00000340878

Symbol
  • NKCC1
  • BSC
  • BSC2
  • NKCC1
  • PPP1R141
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
histone modification site profile
0.85
disease perturbation
0.83
virus perturbation
0.83
gene perturbation
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 885.56   (req: < 5)
Gene RIFs: 54   (req: <= 3)
Antibodies: 338   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 885.56   (req: >= 5)
Gene RIFs: 54   (req: > 3)
Antibodies: 338   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (115)
LGALS3
Tchem
Novelty:  0.00032754
p_int:  0.991768189
p_ni:  0.008231811
Score:  0.235
Data Source:  BioPlex,STRINGDB
LGALS8
Tchem
Novelty:  0.00623836
p_int:  0.980908499
p_ni:  0.019091501
Data Source:  BioPlex
LGALS9
Tchem
Novelty:  0.00381766
p_int:  0.964402877
p_ni:  0.035597121
p_wrong:  2e-9
Score:  0.514
Data Source:  BioPlex,STRINGDB
PSCA
Tbio
Novelty:  0.00323778
p_int:  0.957788016
p_ni:  0.042211984
Data Source:  BioPlex
LGALS9C
Tdark
Novelty:  0.29969898
p_int:  0.945081879
p_ni:  0.054918121
Score:  0.723
Data Source:  BioPlex,STRINGDB
PTGIR
Tclin
Family:  GPCR
Novelty:  0.0091906
p_int:  0.936980632
p_ni:  0.063019368
Data Source:  BioPlex
HTR3A
Tclin
Family:  IC
Novelty:  0.00217443
p_int:  0.913984309
p_ni:  0.08601538
p_wrong:  3.1e-7
Score:  0.277
Data Source:  BioPlex,STRINGDB
TMED6
Tdark
Novelty:  0.598611
p_int:  0.829291257
p_ni:  0.170708735
p_wrong:  8e-9
Data Source:  BioPlex
STK39
Tchem
Family:  Kinase
Novelty:  0.00548476
Score:  0.948
Data Source:  STRINGDB
WNK3
Tchem
Family:  Kinase
Novelty:  0.03382701
Score:  0.908
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Cation-coupled Chloride cotransporters (R-HSA-426117)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cation-coupled Chloride cotransporters
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of inorganic cations/anions and amino acids/oligopeptides
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Cation-coupled Chloride cotransporters
SLC-mediated transmembrane transport
Transport of inorganic cations/anions and amino acids/oligopeptides
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (28)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
7
6
9
99.4
appendicular lean mass
3
4
5
98.5
sex hormone-binding globulin measurement
6
2
6
90.2
body fat distribution
2
1
4
82.1
lymphocyte count
3
1
3
81.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
9
99.4
appendicular lean mass
5
98.5
sex hormone-binding globulin measurement
6
90.2
body fat distribution
4
82.1
lymphocyte count
3
81.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 12 member 2
VGNC:8637
471620
Macaque
solute carrier family 12 member 2
704672
Mouse
MGI:101924
20496
Rat
RGD:620809
83629
Dog
solute carrier family 12 member 2
VGNC:46219
481490
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 12 member 2
Macaque
solute carrier family 12 member 2
Mouse
Rat
Dog
solute carrier family 12 member 2
Publication Statistics
PubMed Score 885.56
PubMed score by year
PubTator Score 326.77
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title