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Tbio
EIF5
Eukaryotic translation initiation factor 5

Protein Summary
Description
Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]). Eukaryotic translation initiation factor-5 (EIF5) interacts with the 40S initiation complex to promote hydrolysis of bound GTP with concomitant joining of the 60S ribosomal subunit to the 40S initiation complex. The resulting functional 80S ribosomal initiation complex is then active in peptidyl transfer and chain elongations (summary by Si et al., 1996 [PubMed 8663286]).[supplied by OMIM, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216554
  • ENSP00000216554
  • ENSG00000100664
  • ENST00000392715
  • ENSP00000376477
  • ENST00000558506
  • ENSP00000453743

Symbol
  • EIF-5
  • EIF-5A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
transcription factor perturbation
1
virus perturbation
1
molecular function
0.96
transcription factor binding site profile
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.53   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 230   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.53   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 230   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
1
1
13.5
erythrocyte measurement
1
1
1
6.7
risky sexual behaviour measurement
1
1
1
2.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
13.5
erythrocyte measurement
1
6.7
risky sexual behaviour measurement
1
2.9
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (8)
Cap-dependent Translation Initiation (R-HSA-72737)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cap-dependent Translation Initiation
Reactome
Eukaryotic Translation Initiation
Reactome
GTP hydrolysis and joining of the 60S ribosomal subunit
Reactome
Metabolism of proteins
Reactome
Ribosomal scanning and start codon recognition
Name
Explore in Pharos
Explore in Source
Cap-dependent Translation Initiation
Eukaryotic Translation Initiation
GTP hydrolysis and joining of the 60S ribosomal subunit
Metabolism of proteins
Ribosomal scanning and start codon recognition
Gene Ontology Terms (14)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (205)
1 – 10 of 205
SLC30A4
Tbio
Family: Transporter
Novelty: 0.02209
p_int: 0.925292082
p_ni: 0.074707918
Score: 0.288
Data Source: BioPlex,STRINGDB
CLPB
Tbio
Family: Enzyme
Novelty: 0.00209789
p_int: 0.845646041
p_ni: 0.154353959
Score: 0.355
Data Source: BioPlex,STRINGDB
EIF3G
Tbio
Novelty: 0.04737601
Score: 0.999
Data Source: STRINGDB
EIF3B
Tbio
Novelty: 0.00889042
Score: 0.998
Data Source: STRINGDB
EIF1
Tbio
Novelty: 0.00590381
Score: 0.997
Data Source: STRINGDB
EIF2S1
Tbio
Novelty: 0.00076124
Score: 0.997
Data Source: STRINGDB
EIF3I
Tbio
Novelty: 0.04398155
Score: 0.994
Data Source: STRINGDB
EIF5B
Tbio
Novelty: 0.00119991
Score: 0.994
Data Source: STRINGDB
EIF4B
Tbio
Novelty: 0.00665561
Score: 0.994
Data Source: STRINGDB
EIF1AX
Tbio
Novelty: 0.01945373
Score: 0.993
Data Source: STRINGDB
Publication Statistics
PubMed Score  105.53

PubMed score by year
PubTator Score  35.28

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer