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Tbio
SLURP1
Secreted Ly-6/uPAR-related protein 1

Protein Summary
Description
Has an antitumor activity (PubMed:8742060). Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin (PubMed:14721776, PubMed:17008884). In vitro down-regulates keratinocyte proliferation; the function may involve the proposed role as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-7-dependent nAChR currents in an allosteric manner (PubMed:14506129, PubMed:26905431). In T cells may be involved in regulation of intracellular Ca(2+) signaling (PubMed:17286989). Seems to have a immunomodulatory function in the cornea (By similarity). The function may implicate a possible role as a scavenger receptor for PLAU thereby blocking PLAU-dependent functions of PLAUR such as in cell migration and proliferation (PubMed:25168896). The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000246515
  • ENSP00000246515
  • ENSG00000126233

Symbol
  • ARS
  • ARS
  • MDM
  • ANUP
  • ArsB
  • LY6LS
  • LY6-MT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.85
tissue
0.53
biological term
0.48
disease
0.43
chemical
0.42


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 144   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 142   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 144   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (38)
1 – 10 of 38
LYPD6
Tbio
Novelty: 0.15409074
Score: 0.901
Data Source: STRINGDB
CHRNA7
Tchem
Family: IC
Novelty: 0.00717396
Score: 0.866
Data Source: STRINGDB
LYNX1
Tbio
Novelty: 0.03651421
Score: 0.807
Data Source: STRINGDB
GML
Tdark
Novelty: 0.00228458
Score: 0.751
Data Source: STRINGDB
LYPD1
Tbio
Novelty: 0.01524003
Score: 0.742
Data Source: STRINGDB
GPIHBP1
Tbio
Novelty: 0.01411894
Score: 0.728
Data Source: STRINGDB
LY6H
Tbio
Novelty: 0.1535649
Score: 0.697
Data Source: STRINGDB
PLAUR
Tchem
Family: Enzyme
Novelty: 0.00096649
Score: 0.669
Data Source: STRINGDB
PATE4
Tdark
Novelty: 0.87378641
Score: 0.664
Data Source: STRINGDB
CAPN3
Tbio
Novelty: 0.00309611
Score: 0.642
Data Source: STRINGDB
Publication Statistics
PubMed Score  144.00

PubMed score by year
PubTator Score  262.34

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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