ADPRH
[Protein ADP-ribosylarginine] hydrolase
Protein Summary
Catalyzes the reverse reaction of mono-ADP-ribosylation. The enzyme encoded by this gene catalyzes removal of mono-ADP-ribose from arginine residues of proteins in the ADP-ribosylation cycle. Unlike the rat and mouse enzymes that require DTT for maximal activity, the human enzyme is DTT-independent. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, May 2014]
- ENST00000357003
- ENSP00000349496
- ENSG00000144843
- ENST00000465513
- ENSP00000417430
- ENST00000478399
- ENSP00000420200
- ENST00000478927
- ENSP00000417528
- ARH1
- ARH1
- hARH1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.85 | ||
disease perturbation | 0.68 | ||
tissue sample | 0.65 | ||
cell line | 0.54 | ||
transcription factor perturbation | 0.54 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7.64 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 128 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7.64 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 128 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0