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Tbio
ADPRH
[Protein ADP-ribosylarginine] hydrolase

Protein Summary
Description
Catalyzes the reverse reaction of mono-ADP-ribosylation. The enzyme encoded by this gene catalyzes removal of mono-ADP-ribose from arginine residues of proteins in the ADP-ribosylation cycle. Unlike the rat and mouse enzymes that require DTT for maximal activity, the human enzyme is DTT-independent. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, May 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357003
  • ENSP00000349496
  • ENSG00000144843
  • ENST00000465513
  • ENSP00000417430
  • ENST00000478399
  • ENSP00000420200
  • ENST00000478927
  • ENSP00000417528

Symbol
  • ARH1
  • ARH1
  • hARH1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.85
disease perturbation
0.68
tissue sample
0.65
cell line
0.54
transcription factor perturbation
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.64   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 128   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.64   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (24)
XRN1
Tbio
Family:  Enzyme
Novelty:  0.00409381
p_int:  0.996705505
p_ni:  0.003272234
p_wrong:  0.000022261
Score:  0.269
Data Source:  BioPlex,STRINGDB
OBSL1
Tbio
Novelty:  0.0325947
p_int:  0.992561611
p_ni:  0.007438389
Score:  0.209
Data Source:  BioPlex,STRINGDB
BCAT1
Tchem
Family:  Enzyme
Novelty:  0.00616446
p_int:  0.821730919
p_ni:  0.178266675
p_wrong:  0.000002406
Score:  0.248
Data Source:  BioPlex,STRINGDB
ADPRHL2
Tbio
Family:  Enzyme
Novelty:  0.02261777
Score:  0.645
Data Source:  STRINGDB
DGAT2
Tchem
Family:  Enzyme
Novelty:  0.00488581
Score:  0.61
Data Source:  STRINGDB
BRD2
Tchem
Family:  Epigenetic
Novelty:  0.00531003
Score:  0.595
Data Source:  STRINGDB
TECR
Tbio
Family:  Enzyme
Novelty:  0.00114749
Score:  0.584
Data Source:  STRINGDB
SPSB1
Tbio
Novelty:  0.13839743
Score:  0.539
Data Source:  STRINGDB
WDTC1
Tbio
Novelty:  0.02300849
Score:  0.532
Data Source:  STRINGDB
PDZK1
Tbio
Novelty:  0.01129974
Score:  0.517
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
primary biliary cirrhosis
6
3
3
1.4
98
multiple sclerosis
3
3
0
1.2
97.3
3
3
0
1.2
94.5
blood protein measurement
2
4
4
90.1
2
2
0
1.3
84.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
primary biliary cirrhosis
3
1.4
98
multiple sclerosis
0
1.2
97.3
0
1.2
94.5
blood protein measurement
4
90.1
0
1.3
84.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1098234
11544
Rat
RGD:2052
25371
Dog
ADP-ribosylarginine hydrolase
VGNC:37670
100855709
Cow
ADP-ribosylarginine hydrolase
VGNC:25690
525738
Pig
ADP-ribosylarginine hydrolase
100153158
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
ADP-ribosylarginine hydrolase
Cow
ADP-ribosylarginine hydrolase
Pig
ADP-ribosylarginine hydrolase
Publication Statistics
PubMed Score 7.64
PubMed score by year
PubTator Score 5.42
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title