You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
HMGCS2
Hydroxymethylglutaryl-CoA synthase, mitochondrial

Protein Summary
Description
This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. The protein encoded by this gene belongs to the HMG-CoA synthase family. It is a mitochondrial enzyme that catalyzes the first reaction of ketogenesis, a metabolic pathway that provides lipid-derived energy for various organs during times of carbohydrate deprivation, such as fasting. Mutations in this gene are associated with HMG-CoA synthase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369406
  • ENSP00000358414
  • ENSG00000134240
  • ENST00000544913
  • ENSP00000439495
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
protein domain
0.85
kinase perturbation
0.71
disease
0.69
gene perturbation
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.81   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 180   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.81   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (26)
Ketone body metabolism (R-HSA-74182)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ketone body metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PPARA activates gene expression
Reactome
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Name
Explore in Pharos
Explore in Source
Ketone body metabolism
Metabolism
Metabolism of lipids
PPARA activates gene expression
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (157)
1 – 10 of 157
NFATC1
Tbio
Family: TF
Novelty: 0.0015406
p_int: 0.999951148
p_ni: 0.000048852
Score: 0.309
Data Source: BioPlex,STRINGDB
SSR3
Tbio
Novelty: 0.12358196
p_int: 0.916191786
p_ni: 0.08377421
p_wrong: 0.000034004
Data Source: BioPlex
PDE4DIP
Tbio
Novelty: 0.04181178
p_int: 0.798004576
p_ni: 0.201974548
p_wrong: 0.000020876
Score: 0.172
Data Source: BioPlex,STRINGDB
HMGCR
Tclin
Family: Enzyme
Novelty: 0.00056109
Score: 0.987
Data Source: STRINGDB
ACAT1
Tchem
Family: Enzyme
Novelty: 0.01281956
Score: 0.982
Data Source: STRINGDB
ACAT2
Tchem
Family: Enzyme
Novelty: 0.01744566
Score: 0.98
Data Source: STRINGDB
PPARA
Tclin
Family: NR
Novelty: 0.00026802
Score: 0.973
Data Source: STRINGDB
HADHB
Tbio
Family: Enzyme
Novelty: 0.01003327
Score: 0.973
Data Source: STRINGDB
HMGCL
Tbio
Family: Enzyme
Novelty: 0.03613197
Score: 0.972
Data Source: STRINGDB
ACAA1
Tbio
Family: Enzyme
Novelty: 0.00482727
Score: 0.972
Data Source: STRINGDB
Publication Statistics
PubMed Score  59.81

PubMed score by year
PubTator Score  69.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: