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Tbio
UGT2B15
UDP-glucuronosyltransferase 2B15

Protein Summary
Description
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays activity toward several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens. This gene encodes a glycosyltransferase that is invovled in the metabolism and elimination of toxic compounts, both endogenous and of xenobiotic origin. This gene plays a role in the regulation of estrogens and androgens. This locus is present in a cluster of similar genes and pseudogenes on chromosome 4. [provided by RefSeq, Aug 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338206
  • ENSP00000341045
  • ENSG00000196620

Symbol
  • UGT2B8
  • HLUG4
  • UGT2B8
  • UDPGTH3
  • UDPGT 2B8
  • UDPGT2B15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
0.92
cell line
0.66
molecular function
0.63
pathway
0.58
phenotype
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.19   (req: < 5)
Gene RIFs: 51   (req: <= 3)
Antibodies: 89   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.19   (req: >= 5)
Gene RIFs: 51   (req: > 3)
Antibodies: 89   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (80)
UGT2A3
Tbio
Family:  Enzyme
Novelty:  0.08423014
p_int:  0.999992329
p_wrong:  0.000007671
Score:  0.749
Data Source:  BioPlex,STRINGDB
SLC35A2
Tbio
Family:  Transporter
Novelty:  0.00072521
Score:  0.868
Data Source:  STRINGDB
CYP3A5
Tclin
Family:  Enzyme
Novelty:  0.00105607
Score:  0.86
Data Source:  STRINGDB
CYP3A4
Tclin
Family:  Enzyme
Novelty:  0.00015515
Score:  0.844
Data Source:  STRINGDB
CYP2D6
Tclin
Family:  Enzyme
Novelty:  0.00021853
Score:  0.841
Data Source:  STRINGDB
AKR1C2
Tchem
Family:  Enzyme
Novelty:  0.00134228
Score:  0.837
Data Source:  STRINGDB
AKR1C3
Tchem
Family:  Enzyme
Novelty:  0.00257785
Score:  0.83
Data Source:  STRINGDB
SRD5A1
Tclin
Family:  Enzyme
Novelty:  0.00987219
Score:  0.83
Data Source:  STRINGDB
CYP2C9
Tchem
Novelty:  0.00041914
Score:  0.829
Data Source:  STRINGDB
CYP1A1
Tchem
Novelty:  0.0002404
Score:  0.826
Data Source:  STRINGDB
Nearest Tclin Targets (17)
Explore Nearest Tclin Targets
1 – 5 of 9
SRD5A2
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  1
SRD5A1
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  1
Pathways (17)
Biological oxidations (R-HSA-211859)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Glucuronidation
Reactome
Metabolism
Reactome
Phase II - Conjugation of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Glucuronidation
Metabolism
Phase II - Conjugation of compounds
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
6
11
98.4
low density lipoprotein cholesterol measurement
4
5
5
96.9
total cholesterol measurement
5
5
6
96.9
serum gamma-glutamyl transferase measurement
2
3
3
92.4
testosterone measurement
3
3
3
92.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
11
98.4
low density lipoprotein cholesterol measurement
5
96.9
total cholesterol measurement
6
96.9
serum gamma-glutamyl transferase measurement
3
92.4
testosterone measurement
3
92.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1919023
71773
Rat
Dog
UDP-glucuronosyltransferase 2B31 [Source:UniProtKB/Swiss-Prot;Acc:Q6K1J1]
Cow
UDP-glucuronosyltransferase 2B17
100140261
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
UDP-glucuronosyltransferase 2B31 [Source:UniProtKB/Swiss-Prot;Acc:Q6K1J1]
Cow
UDP-glucuronosyltransferase 2B17
Publication Statistics
PubMed Score 95.19
PubMed score by year
PubTator Score 91.18
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title