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Tbio
GYS2
Glycogen [starch] synthase, liver

Protein Summary
Description
Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. The protein encoded by this gene, liver glycogen synthase, catalyzes the rate-limiting step in the synthesis of glycogen - the transfer of a glucose molecule from UDP-glucose to a terminal branch of the glycogen molecule. Mutations in this gene cause glycogen storage disease type 0 (GSD-0) - a rare type of early childhood fasting hypoglycemia with decreased liver glycogen content. [provided by RefSeq, Dec 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261195
  • ENSP00000261195
  • ENSG00000111713
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
tissue sample
0.68
cell type or tissue
0.66
gene perturbation
0.58
molecular function
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.2   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.2   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bilirubin measurement
2
8
15
94.5
serum gamma-glutamyl transferase measurement
1
1
1
72.3
hemoglobin measurement
2
2
2
66.6
mean platelet volume
2
2
2
60.8
C-reactive protein measurement
1
1
1
57.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bilirubin measurement
15
94.5
serum gamma-glutamyl transferase measurement
1
72.3
hemoglobin measurement
2
66.6
mean platelet volume
2
60.8
C-reactive protein measurement
1
57.8
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glycogen synthase 2
VGNC:5412
465336
Macaque
glycogen synthase 2
706152
Mouse
MGI:2385254
232493
Rat
RGD:2773
25623
Dog
glycogen synthase 2
VGNC:41575
403737
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glycogen synthase 2
Macaque
glycogen synthase 2
Mouse
Rat
Dog
glycogen synthase 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P54840-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (35)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases of carbohydrate metabolism
Reactome
Diseases of metabolism
Reactome
Glycogen metabolism
Reactome
Glycogen storage disease type 0 (liver GYS2)
Name
Explore in Pharos
Explore in Source
Disease
Diseases of carbohydrate metabolism
Diseases of metabolism
Glycogen metabolism
Glycogen storage disease type 0 (liver GYS2)
Protein-Protein Interactions (122)
1 – 10 of 122
STBD1
Tbio
Novelty:  0.08362185
p_int:  0.826830197
p_ni:  0.173045208
p_wrong:  0.000124595
Score:  0.86
Data Source:  BioPlex,STRINGDB
PPP1R3C
Tbio
Family:  Enzyme
Novelty:  0.01784199
p_int:  0.820755438
p_ni:  0.179141065
p_wrong:  0.000103497
Score:  0.992
Data Source:  BioPlex,Reactome,STRINGDB
PPP1CA
Tchem
Family:  Enzyme
Novelty:  0.00354658
p_int:  0.8107464
p_ni:  0.189114081
p_wrong:  0.000139519
Score:  0.901
Data Source:  BioPlex,STRINGDB
GBE1
Tbio
Family:  Enzyme
Novelty:  0.00233237
Score:  0.995
Data Source:  Reactome,STRINGDB
GYG1
Tbio
Family:  Enzyme
Novelty:  0.01446978
Score:  0.989
Data Source:  STRINGDB
GYG2
Tbio
Family:  Enzyme
Novelty:  0.01520991
Score:  0.986
Data Source:  Reactome,STRINGDB
PPP1R3B
Tbio
Family:  Enzyme
Novelty:  0.0244434
Score:  0.983
Data Source:  STRINGDB
UGP2
Tbio
Family:  Enzyme
Novelty:  0.00760963
Score:  0.976
Data Source:  STRINGDB
EPM2A
Tbio
Novelty:  0.00846992
Score:  0.943
Data Source:  STRINGDB
EPM2A
Tbio
Family:  Enzyme
Novelty:  0.00846992
Score:  0.943
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  63.20

PubMed score by year
PubTator Score  15.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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