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Tchem
PTPN5
Tyrosine-protein phosphatase non-receptor type 5

Protein Summary
Description
May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358540
  • ENSP00000351342
  • ENSG00000110786
  • ENST00000396168
  • ENSP00000379471
  • ENST00000396170
  • ENSP00000379473

Symbol
  • STEP
  • STEP61
  • PTPSTEP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.9
protein domain
0.85
tissue sample
0.72
hub protein
0.71
PubMedID
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.19   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 280   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.19   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 280   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 13
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (13)
CHEMBL3398246
Rendered image for CHEMBL3398246
CHEMBL3398242
Rendered image for CHEMBL3398242
CHEMBL3398244
Rendered image for CHEMBL3398244
CHEMBL3398250
Rendered image for CHEMBL3398250
CHEMBL3398247
Rendered image for CHEMBL3398247
CHEMBL3398248
Rendered image for CHEMBL3398248
CHEMBL3398249
Rendered image for CHEMBL3398249
CHEMBL4077342
Rendered image for CHEMBL4077342
Protein-Protein Interactions (96)
MAPK3
Tchem
Family:  Kinase
Novelty:  0.00012969
Score:  0.952
Data Source:  STRINGDB
MAPK1
Tchem
Family:  Kinase
Novelty:  0.00061058
Score:  0.946
Data Source:  STRINGDB
SMAD3
Tchem
Family:  TF
Novelty:  0.00048058
Score:  0.901
Data Source:  STRINGDB
IL37
Tbio
Novelty:  0.00499186
Score:  0.9
Data Source:  STRINGDB
GRIN2B
Tclin
Family:  IC
Novelty:  0.00035058
Score:  0.896
Data Source:  STRINGDB
DUSP3
Tchem
Family:  Enzyme
Novelty:  0.00518547
Score:  0.853
Data Source:  STRINGDB
PTPRR
Tbio
Family:  Enzyme
Novelty:  0.02065754
Score:  0.827
Data Source:  STRINGDB
PTPN7
Tchem
Family:  Enzyme
Novelty:  0.02742398
Score:  0.813
Data Source:  STRINGDB
FYN
Tclin
Family:  Kinase
Novelty:  0.00072167
Score:  0.801
Data Source:  STRINGDB
MAPK14
Tchem
Family:  Kinase
Novelty:  0.00045138
Score:  0.781
Data Source:  STRINGDB
Pathways (23)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-1 family signaling
Reactome
Interleukin-37 signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-1 family signaling
Interleukin-37 signaling
Signaling by Interleukins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
1
1
1
57.8
Myopia
1
1
0
1.1
55.2
refractive error measurement
1
1
1
38.2
serum albumin measurement
1
1
1
35
apolipoprotein B measurement
1
1
1
26.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
1
57.8
Myopia
0
1.1
55.2
refractive error measurement
1
38.2
serum albumin measurement
1
35
apolipoprotein B measurement
1
26.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, non-receptor type 5
VGNC:7674
466462
Macaque
protein tyrosine phosphatase, non-receptor type 5
708151
Mouse
MGI:97807
19259
Rat
RGD:3448
29644
Dog
protein tyrosine phosphatase, non-receptor type 5
VGNC:45178
485409
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, non-receptor type 5
Macaque
protein tyrosine phosphatase, non-receptor type 5
Mouse
Rat
Dog
protein tyrosine phosphatase, non-receptor type 5
Publication Statistics
PubMed Score 93.19
PubMed score by year
PubTator Score 24.40
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title