Tchem PTPN5 Tyrosine-protein phosphatase non-receptor type 5

Protein Summary

Description

May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors.

Uniprot Accession IDs

• P54829
• B3KXG7
• B7Z386
• B7ZAF5
• D3DQY7
• Q6P1Z2
• Q8N2A1
• Q8NDP8

Gene Name

• PTPN5

Ensembl ID

• ENST00000358540
• ENSP00000351342
• ENSG00000110786
• ENST00000396168
• ENSP00000379471
• ENST00000396170
• ENSP00000379473

Symbol

• STEP
• STEP61
• PTPSTEP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.9
protein domain	0.85
tissue sample	0.72
hub protein	0.71
PubMedID	0.54

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.85   (req: < 5)

Gene RIFs: 23   (req: <= 3)

Antibodies: 280   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.85   (req: >= 5)

Gene RIFs: 23   (req: > 3)

Antibodies: 280   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 13

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0