You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
GAS1
Growth arrest-specific protein 1

Protein Summary
Description
Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells. Growth arrest-specific 1 plays a role in growth suppression. GAS1 blocks entry to S phase and prevents cycling of normal and transformed cells. Gas1 is a putative tumor suppressor gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298743
  • ENSP00000298743
  • ENSG00000180447
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.94
gene perturbation
0.87
transcription factor perturbation
0.84
biological process
0.83
histone modification site profile
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.97   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 215   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.97   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (12)
Activation of SMO (R-HSA-5635838)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of SMO
Reactome
Hedgehog 'on' state
Reactome
Ligand-receptor interactions
Reactome
Signal Transduction
Reactome
Signaling by Hedgehog
Name
Explore in Pharos
Explore in Source
Activation of SMO
Hedgehog 'on' state
Ligand-receptor interactions
Signal Transduction
Signaling by Hedgehog
Protein-Protein Interactions (35)
1 – 10 of 35
SHH
Tchem
Novelty: 0.00033539
Score: 0.987
Data Source: Reactome,STRINGDB
PTCH1
Tbio
Novelty: 0.00096312
Score: 0.971
Data Source: Reactome,STRINGDB
CDON
Tbio
Novelty: 0.00215307
Score: 0.964
Data Source: STRINGDB
IHH
Tbio
Novelty: 0.00230273
Score: 0.95
Data Source: STRINGDB
DHH
Tbio
Novelty: 0.00436048
Score: 0.948
Data Source: STRINGDB
SMO
Tclin
Family: GPCR
Novelty: 0.04792829
Score: 0.937
Data Source: STRINGDB
GAS2
Tbio
Novelty: 0.01827625
Score: 0.932
Data Source: STRINGDB
BOC
Tbio
Novelty: 0.00268665
Score: 0.932
Data Source: STRINGDB
PTCH2
Tbio
Novelty: 0.01422381
Score: 0.897
Data Source: STRINGDB
LRP2
Tbio
Novelty: 0.002005
Score: 0.864
Data Source: STRINGDB
Publication Statistics
PubMed Score  121.97

PubMed score by year
PubTator Score  67.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: