You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PRRX1
Paired mesoderm homeobox protein 1

Protein Summary
Description
Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer (By similarity). The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription co-activator, enhancing the DNA-binding activity of serum response factor, a protein required for the induction of genes by growth and differentiation factors. The protein regulates muscle creatine kinase, indicating a role in the establishment of diverse mesodermal muscle types. Alternative splicing yields two isoforms that differ in abundance and expression patterns. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000239461
  • ENSP00000239461
  • ENSG00000116132
  • ENST00000367760
  • ENSP00000356734

Symbol
  • PMX1
  • PMX1
  • PRX1
  • AGOTC
  • PHOX1
  • PRX-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
PubMedID
0.77
microRNA
0.63
biological process
0.59
transcription factor binding site profile
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.28   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 371   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.28   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 371   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
2
3
96.2
2
3
0
1.1
93.4
body height
1
1
1
41.5
BMI-adjusted hip circumference
1
1
1
32.7
glomerular filtration rate
2
1
2
26.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
96.2
0
1.1
93.4
body height
1
41.5
BMI-adjusted hip circumference
1
32.7
glomerular filtration rate
2
26.7
Gene Ontology Terms (20)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (87)
1 – 10 of 87
HOXB13
Tbio
Family: TF
Novelty: 0.00644371
Score: 0.655
Data Source: STRINGDB
PAX9
Tbio
Family: TF
Novelty: 0.00581813
Score: 0.652
Data Source: STRINGDB
SRF
Tbio
Family: TF
Novelty: 0.00088839
Score: 0.647
Data Source: STRINGDB
TBX15
Tbio
Family: TF
Novelty: 0.03198241
Score: 0.645
Data Source: STRINGDB
NUP98
Tbio
Family: Enzyme
Novelty: 0.00401452
Score: 0.641
Data Source: STRINGDB
WNT9B
Tbio
Novelty: 0.01146843
Score: 0.611
Data Source: STRINGDB
SETD2
Tchem
Family: Epigenetic
Novelty: 0.00178899
Score: 0.583
Data Source: STRINGDB
SYNPO2L
Tbio
Novelty: 0.21505129
Score: 0.582
Data Source: STRINGDB
TWIST1
Tbio
Family: TF
Novelty: 0.0013639
Score: 0.581
Data Source: STRINGDB
SNAI2
Tbio
Family: TF
Novelty: 0.00096495
Score: 0.577
Data Source: STRINGDB
Publication Statistics
PubMed Score  92.28

PubMed score by year
PubTator Score  58.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: