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Tbio
AK2
Adenylate kinase 2, mitochondrial

Protein Summary
Description
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2, and 3, have been identified in vertebrates; this gene encodes isozyme 2. Expression of these isozymes is tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis. Mutations in this gene are the cause of reticular dysgenesis. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1 and 2.[p ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354858
  • ENSP00000346921
  • ENSG00000004455
  • ENST00000373449
  • ENSP00000362548

Symbol
  • ADK2
  • ADK2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
virus perturbation
1
disease perturbation
0.97
transcription factor perturbation
0.94
microRNA
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 174.43   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 426   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 174.43   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 426   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (161)
1 – 10 of 161
AIFM1
Tbio
Novelty:  0.00940088
p_int:  0.832008101
p_ni:  0.167991899
Score:  0.31
Data Source:  BioPlex,STRINGDB
ADK
Tchem
Family:  Kinase
Novelty:  0.00196435
Score:  0.979
Data Source:  STRINGDB
ADSL
Tbio
Family:  Enzyme
Novelty:  0.0028496
Score:  0.967
Data Source:  STRINGDB
APRT
Tchem
Family:  Enzyme
Novelty:  0.00483077
Score:  0.967
Data Source:  STRINGDB
ATP5F1D
Tbio
Family:  Enzyme
Novelty:  0.07296539
Score:  0.934
Data Source:  STRINGDB
ATP5F1B
Tbio
Family:  Enzyme
Novelty:  0.01053177
Score:  0.933
Data Source:  STRINGDB
ATP5F1C
Tbio
Family:  Enzyme
Novelty:  0.07666564
Score:  0.93
Data Source:  STRINGDB
RRM2B
Tbio
Family:  Enzyme
Novelty:  0.00817283
Score:  0.929
Data Source:  STRINGDB
ATP5PD
Tbio
Family:  Enzyme
Novelty:  0.0730514
Score:  0.929
Data Source:  STRINGDB
PNPT1
Tbio
Family:  Enzyme
Novelty:  0.00339969
Score:  0.929
Data Source:  STRINGDB
Pathways (9)
Interconversion of nucleotide di- and triphosphates (R-HSA-499943)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Interconversion of nucleotide di- and triphosphates
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Name
Explore in Pharos
Explore in Source
Interconversion of nucleotide di- and triphosphates
Metabolism
Metabolism of nucleotides
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gut microbiome measurement
1
1
1
14.2
mosaic loss of chromosome Y measurement
1
1
1
3.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gut microbiome measurement
1
14.2
mosaic loss of chromosome Y measurement
1
3.8
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adenylate kinase 2
VGNC:55
456723
Macaque
adenylate kinase 2
709737
Mouse
MGI:87978
11637
Rat
RGD:2077
24184
Dog
adenylate kinase 2
VGNC:37746
478145
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adenylate kinase 2
Macaque
adenylate kinase 2
Mouse
Rat
Dog
adenylate kinase 2
Publication Statistics
PubMed Score 174.43
PubMed score by year
PubTator Score 66.13
PubTator score by year
Patents
Patents by year