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Tbio
NAGLU
Alpha-N-acetylglucosaminidase

Protein Summary
Description
Involved in the degradation of heparan sulfate. This gene encodes an enzyme that degrades heparan sulfate by hydrolysis of terminal N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides. Defects in this gene are the cause of mucopolysaccharidosis type IIIB (MPS-IIIB), also known as Sanfilippo syndrome B. This disease is characterized by the lysosomal accumulation and urinary excretion of heparan sulfate. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000225927
  • ENSP00000225927
  • ENSG00000108784

Symbol
  • UFHSD1
  • NAG
  • CMT2V
  • MPS3B
  • UFHSD
  • MPS-IIIB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.9
transcription factor perturbation
0.8
cellular component
0.73
protein domain
0.73
transcription factor binding site profile
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.37   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 92   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.37   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
4
2
1
91.4
waist-hip ratio
3
6
6
82
BMI-adjusted waist-hip ratio
1
4
4
76.4
sex hormone-binding globulin measurement
4
2
4
75.4
triglyceride measurement
3
2
3
68.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
91.4
waist-hip ratio
6
82
BMI-adjusted waist-hip ratio
4
76.4
sex hormone-binding globulin measurement
4
75.4
triglyceride measurement
3
68.3
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
N-acetyl-alpha-glucosaminidase
VGNC:9468
468265
Macaque
N-acetyl-alpha-glucosaminidase
707186
Mouse
MGI:1351641
27419
Rat
RGD:1564228
360630
Dog
N-acetyl-alpha-glucosaminidase
VGNC:43609
490965
Species
Name
OMA
EggNOG
Inparanoid
Chimp
N-acetyl-alpha-glucosaminidase
Macaque
N-acetyl-alpha-glucosaminidase
Mouse
Rat
Dog
N-acetyl-alpha-glucosaminidase
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P54802-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (17)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases of carbohydrate metabolism
Reactome
Diseases of metabolism
Reactome
Glycosaminoglycan metabolism
Reactome
HS-GAG degradation
Name
Explore in Pharos
Explore in Source
Disease
Diseases of carbohydrate metabolism
Diseases of metabolism
Glycosaminoglycan metabolism
HS-GAG degradation
Gene Ontology Terms (12)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (99)
1 – 10 of 99
OSBPL5
Tbio
Novelty:  0.05262202
p_int:  0.999812115
p_ni:  0.000187885
Score:  0.229
Data Source:  BioPlex,STRINGDB
TAZ
Tbio
Novelty:  0.00372301
p_int:  0.991479858
p_ni:  0.008520142
Score:  0.152
Data Source:  BioPlex,STRINGDB
RLN1
Tbio
Novelty:  0.03992636
p_int:  0.976394476
p_ni:  0.023605524
Data Source:  BioPlex
NAAA
Tchem
Family:  Enzyme
Novelty:  0.00368876
p_int:  0.974969492
p_ni:  0.025030508
Data Source:  BioPlex
SLAMF1
Tbio
Novelty:  0.00112892
p_int:  0.970279366
p_ni:  0.029720634
Data Source:  BioPlex
SCGB2A1
Tbio
Novelty:  0.01902973
p_int:  0.963881911
p_ni:  0.036118089
Data Source:  BioPlex
LGALS9
Tchem
Novelty:  0.00381766
p_int:  0.950923082
p_ni:  0.049076918
Data Source:  BioPlex
FBXO6
Tbio
Novelty:  0.02173918
p_int:  0.950593016
p_ni:  0.049406984
Data Source:  BioPlex
PLAUR
Tchem
Family:  Enzyme
Novelty:  0.00087642
p_int:  0.946934252
p_ni:  0.053065748
Data Source:  BioPlex
SUSD4
Tbio
Novelty:  0.22201938
p_int:  0.933780632
p_ni:  0.066219368
Data Source:  BioPlex
Publication Statistics
PubMed Score  112.37

PubMed score by year
PubTator Score  397.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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