Tbio NAGLU Alpha-N-acetylglucosaminidase

Protein Summary

Description

Involved in the degradation of heparan sulfate. This gene encodes an enzyme that degrades heparan sulfate by hydrolysis of terminal N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides. Defects in this gene are the cause of mucopolysaccharidosis type IIIB (MPS-IIIB), also known as Sanfilippo syndrome B. This disease is characterized by the lysosomal accumulation and urinary excretion of heparan sulfate. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P54802

Gene Name

• NAGLU

Ensembl ID

• ENST00000225927
• ENSP00000225927
• ENSG00000108784

Symbol

• UFHSD1
• NAG
• CMT2V
• MPS3B
• UFHSD
• MPS-IIIB

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.9
transcription factor perturbation	0.8
cellular component	0.73
protein domain	0.73
transcription factor binding site profile	0.72

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.85   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 92   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.85   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0