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Tchem
EPHA4
Ephrin type-A receptor 4

Protein Summary
Description
Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. I ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000281821
  • ENSP00000281821
  • ENSG00000116106
  • ENST00000409938
  • ENSP00000386829

Symbol
  • HEK8
  • SEK
  • TYRO1
  • EK8
  • SEK
  • HEK8
  • TYRO1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
1
biological process
0.97
PubMedID
0.97
transcription factor perturbation
0.96


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 351.34   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 635   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 351.34   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 635   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 48
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
1
2
80.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
80.6
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
EPH receptor A4
VGNC:10781
470660
Macaque
EPH receptor A4
704857
Mouse
MGI:98277
13838
Rat
RGD:1560587
316539
Dog
EPH receptor A4
VGNC:40407
478925
Species
Name
OMA
EggNOG
Inparanoid
Chimp
EPH receptor A4
Macaque
EPH receptor A4
Mouse
Rat
Dog
EPH receptor A4
Protein Structure (15 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P54764-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 15
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (11)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
EPH-Ephrin signaling
Reactome
EPH-ephrin mediated repulsion of cells
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
EPH-Ephrin signaling
EPH-ephrin mediated repulsion of cells
Gene Ontology Terms (73)
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Genetic Interaction (IGI)
ARUK-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ARUK-UCL
Protein-Protein Interactions (184)
1 – 10 of 184
EFNA5
Tbio
Novelty: 0.00134985
p_int: 0.999418723
p_ni: 0.000581277
Score: 0.999
Data Source: BioPlex,STRINGDB
IARS2
Tbio
Family: Enzyme
Novelty: 0.00854621
p_int: 0.99924068
p_ni: 0.00075932
Data Source: BioPlex
CALML3
Tbio
Novelty: 0.0336689
p_int: 0.99884891
p_ni: 0.001151028
p_wrong: 6.3e-8
Data Source: BioPlex
COPZ1
Tbio
Novelty: 0.01405958
p_int: 0.998231872
p_ni: 0.001768128
p_wrong: 1e-9
Data Source: BioPlex
RSPH14
Tdark
Novelty: 0.53463266
p_int: 0.99772695
p_ni: 0.00227305
Score: 0.199
Data Source: BioPlex,STRINGDB
CPA5
Tbio
Family: Enzyme
Novelty: 0.0516555
p_int: 0.992916647
p_ni: 0.007083353
Data Source: BioPlex
TBC1D22A
Tbio
Novelty: 0.46374046
p_int: 0.992244291
p_ni: 0.007755709
Score: 0.154
Data Source: BioPlex,STRINGDB
CTLA4
Tclin
Novelty: 0.00012781
p_int: 0.987411446
p_ni: 0.012588513
p_wrong: 4e-8
Data Source: BioPlex
TUBB
Tclin
Novelty: 0.0038007
p_int: 0.98695319
p_ni: 0.01304681
Score: 0.158
Data Source: BioPlex,STRINGDB
TMEM9
Tbio
Novelty: 0.06916197
p_int: 0.98106841
p_ni: 0.01893159
Data Source: BioPlex
Publication Statistics
PubMed Score  351.34

PubMed score by year
PubTator Score  116.72

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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