You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
EPHB1
Ephrin type-B receptor 1

Protein Summary
Description
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formatio ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000398015
  • ENSP00000381097
  • ENSG00000154928
  • ENST00000493838
  • ENSP00000419574

Symbol
  • ELK
  • EPHT2
  • HEK6
  • NET
  • ELK
  • NET
  • Hek6
  • EPHT2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.99
biological process
0.82
trait
0.75
transcription factor binding site profile
0.73


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.21   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 524   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.21   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 524   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 36
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
dasatinib
chemical structure image
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metastatic colorectal cancer
1
1
0
217
62.2
disease progression measurement
1
1
0
217
62.2
metastasis measurement
1
1
0
217
62.2
appendicular lean mass
1
1
1
49.9
neuroticism measurement
1
1
1
40.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metastatic colorectal cancer
0
217
62.2
disease progression measurement
0
217
62.2
metastasis measurement
0
217
62.2
appendicular lean mass
1
49.9
neuroticism measurement
1
40.8
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
EPH receptor B1
VGNC:6219
460714
Mouse
MGI:1096337
270190
Rat
RGD:2556
24338
Dog
EPH receptor B1
VGNC:49889
485671
Opossum
EPH receptor B1
100023496
Species
Name
OMA
EggNOG
Inparanoid
Chimp
EPH receptor B1
Mouse
Rat
Dog
EPH receptor B1
Opossum
EPH receptor B1
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (84)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
EPH-Ephrin signaling
Reactome
EPH-ephrin mediated repulsion of cells
Reactome
Ephrin signaling
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
EPH-Ephrin signaling
EPH-ephrin mediated repulsion of cells
Ephrin signaling
Gene Ontology Terms (51)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (161)
1 – 10 of 161
KLRG2
Tdark
Novelty: 1.19446694
p_int: 0.999996812
p_ni: 1.44e-7
p_wrong: 0.000003044
Score: 0.243
Data Source: BioPlex,STRINGDB
EFNA5
Tbio
Novelty: 0.00134985
Score: 0.998
Data Source: STRINGDB
EFNB2
Tbio
Novelty: 0.00255095
Score: 0.998
Data Source: STRINGDB
EFNB1
Tbio
Novelty: 0.00523161
Score: 0.996
Data Source: STRINGDB
EFNA1
Tbio
Family: Kinase
Novelty: 0.00732252
Score: 0.995
Data Source: STRINGDB
EFNB3
Tbio
Novelty: 0.0120367
Score: 0.993
Data Source: STRINGDB
EFNA2
Tbio
Novelty: 0.01184859
Score: 0.993
Data Source: STRINGDB
EFNA4
Tbio
Novelty: 0.03628159
Score: 0.992
Data Source: STRINGDB
EFNA3
Tbio
Novelty: 0.01819539
Score: 0.992
Data Source: STRINGDB
NCK1
Tbio
Novelty: 0.00352084
Score: 0.978
Data Source: STRINGDB
Publication Statistics
PubMed Score  71.21

PubMed score by year
PubTator Score  38.87

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: