Protein Classes
Protein Summary
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formatio ...more
- ENST00000398015
- ENSP00000381097
- ENSG00000154928
- ENST00000493838
- ENSP00000419574
- ELK
- EPHT2
- HEK6
- NET
- ELK
- NET
- Hek6
- EPHT2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
molecular function | 0.99 | ||
biological process | 0.82 | ||
trait | 0.75 | ||
transcription factor binding site profile | 0.73 | ||
IDG Partner Tools
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 71.21 (req: < 5)
Gene RIFs: 28 (req: <= 3)
Antibodies: 524 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 71.21 (req: >= 5)
Gene RIFs: 28 (req: > 3)
Antibodies: 524 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 36
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 5
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
Active Ligands (5)
1 – 5 of 5
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
metastatic colorectal cancer | 1 | 1 | 0 | 217 | 62.2 | ||||
disease progression measurement | 1 | 1 | 0 | 217 | 62.2 | ||||
metastasis measurement | 1 | 1 | 0 | 217 | 62.2 | ||||
appendicular lean mass | 1 | 1 | 1 | 49.9 | |||||
neuroticism measurement | 1 | 1 | 1 | 40.8 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
metastatic colorectal cancer | 0 | 217 | 62.2 | ||||
disease progression measurement | 0 | 217 | 62.2 | ||||
metastasis measurement | 0 | 217 | 62.2 | ||||
appendicular lean mass | 1 | 49.9 | |||||
neuroticism measurement | 1 | 40.8 | |||||
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (84)
Reactome (5)
KEGG (1)
PathwayCommons (5)
WikiPathways (73)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 5
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Developmental Biology | ||||
Reactome | EPH-Ephrin signaling | ||||
Reactome | EPH-ephrin mediated repulsion of cells | ||||
Reactome | Ephrin signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Axon guidance | ||||
Developmental Biology | ||||
EPH-Ephrin signaling | ||||
EPH-ephrin mediated repulsion of cells | ||||
Ephrin signaling | ||||
Gene Ontology Terms (51)
Functions (7)
Components (15)
Processes (29)
Items per page:
10
1 – 7 of 7
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (161)
1 – 10 of 161
KLRG2
Novelty: 1.19446694
p_int: 0.999996812
p_ni: 1.44e-7
p_wrong: 0.000003044
Score: 0.243
Data Source: BioPlex,STRINGDB
EFNA5
Novelty: 0.00134985
Score: 0.998
Data Source: STRINGDB
EFNB2
Novelty: 0.00255095
Score: 0.998
Data Source: STRINGDB
EFNB1
Novelty: 0.00523161
Score: 0.996
Data Source: STRINGDB
EFNA1
Family: Kinase
Novelty: 0.00732252
Score: 0.995
Data Source: STRINGDB
EFNB3
Novelty: 0.0120367
Score: 0.993
Data Source: STRINGDB
EFNA2
Novelty: 0.01184859
Score: 0.993
Data Source: STRINGDB
EFNA4
Novelty: 0.03628159
Score: 0.992
Data Source: STRINGDB
EFNA3
Novelty: 0.01819539
Score: 0.992
Data Source: STRINGDB
NCK1
Novelty: 0.00352084
Score: 0.978
Data Source: STRINGDB
Publication Statistics
PubMed Score 71.21
PubMed score by year
PubTator Score 38.87
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Ortholog Sequence Conservation
PolarG S T Y C
NeutralQ N
BasicK R H
AcidicD E
HydrophobicA V L I P W F M
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UniProt Keyword
GWAS Trait