Protein Summary
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis. Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divi ...more
- ENST00000358173
- ENSP00000350896
- ENSG00000196411
- ENST00000616502
- ENSP00000482702
- HTK
- MYK1
- TYRO11
- HTK
- MYK1
- HFASD
- CMAVM2
- LMPHM7
- TYRO11
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 1 | ||
molecular function | 0.98 | ||
PubMedID | 0.86 | ||
transcription factor binding site profile | 0.83 | ||
kinase perturbation | 0.81 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 294.21 (req: < 5)
Gene RIFs: 100 (req: <= 3)
Antibodies: 627 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 294.21 (req: >= 5)
Gene RIFs: 100 (req: > 3)
Antibodies: 627 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 16
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 106
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 3
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (3)
Active Ligands (106)
Protein-Protein Interactions (175)
EFNB2
Novelty: 0.00255095
p_int: 0.999998976
p_ni: 0.00000102
p_wrong: 4e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
SCGB2A2
Novelty: 0.01594053
p_int: 0.997616025
p_ni: 0.002383948
p_wrong: 2.7e-8
Score: 0.198
Data Source: BioPlex,STRINGDB
TCTN2
Novelty: 0.11617528
p_int: 0.996846043
p_ni: 0.003153951
p_wrong: 7e-9
Data Source: BioPlex
SCGB2A1
Novelty: 0.01902973
p_int: 0.996237235
p_ni: 0.003762763
p_wrong: 2e-9
Data Source: BioPlex
MANSC1
Novelty: 0.91681036
p_int: 0.996172052
p_ni: 0.003827448
p_wrong: 5.01e-7
Data Source: BioPlex
KLRG2
Novelty: 1.19446694
p_int: 0.989727321
p_ni: 0.010271095
p_wrong: 0.000001584
Score: 0.172
Data Source: BioPlex,STRINGDB
PCDHGA5
Novelty: 2.13631603
p_int: 0.986744476
p_ni: 0.013236317
p_wrong: 0.000019207
Score: 0.172
Data Source: BioPlex,STRINGDB
TMPRSS3
Family: Enzyme
Novelty: 0.0268524
p_int: 0.978692288
p_ni: 0.021119659
p_wrong: 0.000188053
Data Source: BioPlex
GABRE
Family: IC
Novelty: 0.03814541
p_int: 0.977830344
p_ni: 0.022169655
p_wrong: 1e-9
Data Source: BioPlex
HLA-DRA
Novelty: 0.0060214
p_int: 0.977205536
p_ni: 0.022792663
p_wrong: 0.000001801
Data Source: BioPlex
Nearest Tclin Targets (1)
Downstream (1)
1 – 1 of 1
Pathways (25)
Reactome (5)
KEGG (1)
PathwayCommons (4)
WikiPathways (15)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Developmental Biology | ||||
Reactome | EPH-Ephrin signaling | ||||
Reactome | EPH-ephrin mediated repulsion of cells | ||||
Reactome | Ephrin signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Axon guidance | ||||
Developmental Biology | ||||
EPH-Ephrin signaling | ||||
EPH-ephrin mediated repulsion of cells | ||||
Ephrin signaling | ||||
Viral Interactions (0)
Gene Ontology Terms (24)
Functions (6)
Components (8)
Processes (10)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (28)
Items per page:
1 – 5 of 28
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
hematocrit | 4 | 6 | 9 | 99.1 | |||||
hemoglobin measurement | 4 | 4 | 7 | 98 | |||||
sex hormone-binding globulin measurement | 6 | 3 | 6 | 96.5 | |||||
erythrocyte count | 2 | 3 | 3 | 95.8 | |||||
hair color | 1 | 3 | 0 | 1.1 | 93.5 | ||||
Items per page:
1 – 5 of 28
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
hematocrit | 9 | 99.1 | |||||
hemoglobin measurement | 7 | 98 | |||||
sex hormone-binding globulin measurement | 6 | 96.5 | |||||
erythrocyte count | 3 | 95.8 | |||||
hair color | 0 | 1.1 | 93.5 | ||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | EPH receptor B4 | VGNC:4339 | 463610 | |||||
Macaque | EPH receptor B4 | 719320 | ||||||
Mouse | MGI:104757 | 13846 | ||||||
Rat | RGD:1583193 | 686310 | ||||||
Dog | EPH receptor B4 | VGNC:40413 | 489830 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | EPH receptor B4 | |||||
Macaque | EPH receptor B4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | EPH receptor B4 | |||||
Publication Statistics
PubMed Score 294.21
PubMed score by year
PubTator Score 166.17
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (127)
GeneRif Annotations (100)
Items per page:
0 of 0
PMID | Year | Title |
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