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Tchem
EPHA5
Ephrin type-A receptor 5

Protein Summary
Description
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity). This gene belongs to th ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273854
  • ENSP00000273854
  • ENSG00000145242
  • ENST00000354839
  • ENSP00000346899

Symbol
  • BSK
  • EHK1
  • HEK7
  • TYRO4
  • EK7
  • CEK7
  • EHK1
  • HEK7
  • EHK-1
  • TYRO4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.99
kinase perturbation
0.81
microRNA
0.77
virus perturbation
0.72


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.64   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 487   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.64   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 487   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
2
4
95.5
self reported educational attainment
2
3
3
89.1
cognitive function measurement
1
1
1
82
intelligence
1
1
1
25.4
1
1
1
25.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
95.5
self reported educational attainment
3
89.1
cognitive function measurement
1
82
intelligence
1
25.4
1
25.4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
EPH receptor A5
VGNC:2035
461299
Macaque
EPH receptor A5
712074
Mouse
MGI:99654
13839
Rat
RGD:620831
79208
Dog
EPH receptor A5
VGNC:40408
100684553
Species
Name
OMA
EggNOG
Inparanoid
Chimp
EPH receptor A5
Macaque
EPH receptor A5
Mouse
Rat
Dog
EPH receptor A5
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P54756-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
EPH-Ephrin signaling
Reactome
EPH-ephrin mediated repulsion of cells
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
EPH-Ephrin signaling
EPH-ephrin mediated repulsion of cells
Gene Ontology Terms (30)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (120)
1 – 10 of 120
EFNA5
Tbio
Novelty: 0.00134985
p_int: 0.999997399
p_ni: 3.11e-7
p_wrong: 0.00000229
Score: 0.998
Data Source: BioPlex,STRINGDB
CST9L
Tdark
Novelty: 0.21941207
p_int: 0.999606149
p_ni: 0.000004429
p_wrong: 0.000389423
Data Source: BioPlex
TSPAN3
Tbio
Novelty: 0.06362133
p_int: 0.99769917
p_ni: 3.56e-7
p_wrong: 0.002300474
Score: 0.77
Data Source: BioPlex,STRINGDB
EFNB2
Tbio
Novelty: 0.00255095
p_int: 0.996609814
p_ni: 3.14e-7
p_wrong: 0.003389872
Score: 0.999
Data Source: BioPlex,STRINGDB
EFNA1
Tbio
Family: Kinase
Novelty: 0.00732252
Score: 0.995
Data Source: STRINGDB
EFNA3
Tbio
Novelty: 0.01819539
Score: 0.995
Data Source: STRINGDB
EFNA2
Tbio
Novelty: 0.01184859
Score: 0.995
Data Source: STRINGDB
EFNA4
Tbio
Novelty: 0.03628159
Score: 0.995
Data Source: STRINGDB
EFNB1
Tbio
Novelty: 0.00523161
Score: 0.993
Data Source: STRINGDB
EFNB3
Tbio
Novelty: 0.0120367
Score: 0.993
Data Source: STRINGDB
Publication Statistics
PubMed Score  88.64

PubMed score by year
PubTator Score  33.29

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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