Protein Summary
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity). This gene belongs to th ...more
- ENST00000273854
- ENSP00000273854
- ENSG00000145242
- ENST00000354839
- ENSP00000346899
- BSK
- EHK1
- HEK7
- TYRO4
- EK7
- CEK7
- EHK1
- HEK7
- EHK-1
- TYRO4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 1 | ||
molecular function | 0.99 | ||
kinase perturbation | 0.81 | ||
microRNA | 0.77 | ||
virus perturbation | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 92.71 (req: < 5)
Gene RIFs: 15 (req: <= 3)
Antibodies: 487 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 92.71 (req: >= 5)
Gene RIFs: 15 (req: > 3)
Antibodies: 487 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 19
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 7
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 3
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (3)
Active Ligands (7)
Protein-Protein Interactions (120)
EFNA5
Novelty: 0.00134985
p_int: 0.999997399
p_ni: 3.11e-7
p_wrong: 0.00000229
Score: 0.998
Data Source: BioPlex,STRINGDB
CST9L
Novelty: 0.21941207
p_int: 0.999606149
p_ni: 0.000004429
p_wrong: 0.000389423
Data Source: BioPlex
TSPAN3
Novelty: 0.06362133
p_int: 0.99769917
p_ni: 3.56e-7
p_wrong: 0.002300474
Score: 0.77
Data Source: BioPlex,STRINGDB
EFNB2
Novelty: 0.00255095
p_int: 0.996609814
p_ni: 3.14e-7
p_wrong: 0.003389872
Score: 0.999
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (1)
Downstream (1)
1 – 1 of 1
Pathways (8)
Reactome (4)
KEGG (1)
PathwayCommons (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Developmental Biology | ||||
Reactome | EPH-Ephrin signaling | ||||
Reactome | EPH-ephrin mediated repulsion of cells | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Axon guidance | ||||
Developmental Biology | ||||
EPH-Ephrin signaling | ||||
EPH-ephrin mediated repulsion of cells | ||||
Viral Interactions (0)
Gene Ontology Terms (30)
Functions (6)
Components (11)
Processes (13)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
mathematical ability | 4 | 2 | 4 | 77.8 | |||||
self reported educational attainment | 2 | 3 | 3 | 72 | |||||
cognitive function measurement | 1 | 1 | 1 | 56.8 | |||||
risk-taking behaviour | 1 | 1 | 1 | 42.3 | |||||
1 | 1 | 1 | 33.1 | ||||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
mathematical ability | 4 | 77.8 | |||||
self reported educational attainment | 3 | 72 | |||||
cognitive function measurement | 1 | 56.8 | |||||
risk-taking behaviour | 1 | 42.3 | |||||
1 | 33.1 | ||||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | EPH receptor A5 | VGNC:2035 | 461299 | |||||
Macaque | EPH receptor A5 | 712074 | ||||||
Mouse | MGI:99654 | 13839 | ||||||
Rat | RGD:620831 | 79208 | ||||||
Dog | EPH receptor A5 | VGNC:40408 | 100684553 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | EPH receptor A5 | |||||
Macaque | EPH receptor A5 | |||||
Mouse | ||||||
Rat | ||||||
Dog | EPH receptor A5 | |||||
Publication Statistics
PubMed Score 92.71
PubMed score by year
PubTator Score 33.29
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (41)
GeneRif Annotations (15)
Items per page:
0 of 0
PMID | Year | Title |
---|