Protein Summary
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis, ...more
- ENST00000330394
- ENSP00000332118
- ENSG00000182580
- ETK2
- HEK2
- TYRO6
- EK2
- ETK2
- HEK2
- TYRO6
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 1 | ||
molecular function | 0.98 | ||
PubMedID | 0.82 | ||
biological process | 0.78 | ||
transcription factor binding site profile | 0.72 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 100.94 (req: < 5)
Gene RIFs: 18 (req: <= 3)
Antibodies: 510 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 100.94 (req: >= 5)
Gene RIFs: 18 (req: > 3)
Antibodies: 510 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 31
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
Active Ligands (2)
1 – 2 of 2
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
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PDB Structure Id | M.W. | Resolution | Pub Year |
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Pathways (14)
Reactome (5)
KEGG (1)
PathwayCommons (4)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 5
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Developmental Biology | ||||
Reactome | EPH-Ephrin signaling | ||||
Reactome | EPH-ephrin mediated repulsion of cells | ||||
Reactome | Ephrin signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Axon guidance | ||||
Developmental Biology | ||||
EPH-Ephrin signaling | ||||
EPH-ephrin mediated repulsion of cells | ||||
Ephrin signaling | ||||
Gene Ontology Terms (39)
Functions (7)
Components (8)
Processes (24)
Items per page:
10
1 – 7 of 7
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (126)
1 – 10 of 126
EFNB2
Novelty: 0.00309066
p_int: 0.999988876
p_ni: 0.000011124
Score: 0.998
Data Source: BioPlex,STRINGDB
C16orf58
Novelty: 0.00625312
p_int: 0.999584618
p_ni: 0.000414807
p_wrong: 5.74e-7
Score: 0.189
Data Source: BioPlex,STRINGDB
ADGRG5
Family: GPCR
Novelty: 0.38877844
p_int: 0.998203905
p_ni: 0.001780833
p_wrong: 0.000015262
Score: 0.159
Data Source: BioPlex,STRINGDB
EFNA5
Novelty: 0.00173565
Score: 0.997
Data Source: STRINGDB
EFNB3
Novelty: 0.01171599
Score: 0.995
Data Source: STRINGDB
EFNB1
Novelty: 0.00491089
Score: 0.995
Data Source: STRINGDB
EFNA3
Novelty: 0.01717372
Score: 0.993
Data Source: STRINGDB
EFNA2
Novelty: 0.0109729
Score: 0.992
Data Source: STRINGDB
EFNA4
Novelty: 0.02322294
Score: 0.992
Data Source: STRINGDB
EFNA1
Family: Kinase
Novelty: 0.00738582
Score: 0.992
Data Source: STRINGDB
Publication Statistics
PubMed Score 100.94
PubMed score by year
PubTator Score 48.52
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Ortholog Sequence Conservation
PolarG S T Y C
NeutralQ N
BasicK R H
AcidicD E
HydrophobicA V L I P W F M
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