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Tchem
EPHB3
Ephrin type-B receptor 3

Protein Summary
Description
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330394
  • ENSP00000332118
  • ENSG00000182580

Symbol
  • ETK2
  • HEK2
  • TYRO6
  • EK2
  • ETK2
  • HEK2
  • TYRO6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.98
PubMedID
0.82
biological process
0.78
transcription factor binding site profile
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.94   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 510   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.94   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 510   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
dasatinib
chemical structure image
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (14)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
EPH-Ephrin signaling
Reactome
EPH-ephrin mediated repulsion of cells
Reactome
Ephrin signaling
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
EPH-Ephrin signaling
EPH-ephrin mediated repulsion of cells
Ephrin signaling
Gene Ontology Terms (39)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (126)
1 – 10 of 126
EFNB2
Tbio
Novelty: 0.00309066
p_int: 0.999988876
p_ni: 0.000011124
Score: 0.998
Data Source: BioPlex,STRINGDB
C16orf58
Tdark
Novelty: 0.00625312
p_int: 0.999584618
p_ni: 0.000414807
p_wrong: 5.74e-7
Score: 0.189
Data Source: BioPlex,STRINGDB
ADGRG5
Tdark
Family: GPCR
Novelty: 0.38877844
p_int: 0.998203905
p_ni: 0.001780833
p_wrong: 0.000015262
Score: 0.159
Data Source: BioPlex,STRINGDB
EFNA5
Tbio
Novelty: 0.00173565
Score: 0.997
Data Source: STRINGDB
EFNB3
Tbio
Novelty: 0.01171599
Score: 0.995
Data Source: STRINGDB
EFNB1
Tbio
Novelty: 0.00491089
Score: 0.995
Data Source: STRINGDB
EFNA3
Tbio
Novelty: 0.01717372
Score: 0.993
Data Source: STRINGDB
EFNA2
Tbio
Novelty: 0.0109729
Score: 0.992
Data Source: STRINGDB
EFNA4
Tbio
Novelty: 0.02322294
Score: 0.992
Data Source: STRINGDB
EFNA1
Tbio
Family: Kinase
Novelty: 0.00738582
Score: 0.992
Data Source: STRINGDB
Publication Statistics
PubMed Score  100.94

PubMed score by year
PubTator Score  48.52

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer