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Tchem
EPHB3
Ephrin type-B receptor 3

Protein Summary
Description
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330394
  • ENSP00000332118
  • ENSG00000182580

Symbol
  • ETK2
  • HEK2
  • TYRO6
  • EK2
  • ETK2
  • HEK2
  • TYRO6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.98
PubMedID
0.82
biological process
0.78
transcription factor binding site profile
0.72


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.37   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 510   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.37   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 510   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
dasatinib
chemical structure image
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
nose morphology measurement
1
1
1
6.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
nose morphology measurement
1
6.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
EPH receptor B3
VGNC:1810
460894
Macaque
EPH receptor B3
701811
Mouse
MGI:104770
13845
Rat
RGD:1305602
287989
Dog
EPH receptor B3
VGNC:40412
488108
Species
Name
OMA
EggNOG
Inparanoid
Chimp
EPH receptor B3
Macaque
EPH receptor B3
Mouse
Rat
Dog
EPH receptor B3
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (14)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
EPH-Ephrin signaling
Reactome
EPH-ephrin mediated repulsion of cells
Reactome
Ephrin signaling
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
EPH-Ephrin signaling
EPH-ephrin mediated repulsion of cells
Ephrin signaling
Gene Ontology Terms (39)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (126)
1 – 10 of 126
EFNB2
Tbio
Novelty: 0.00255095
p_int: 0.999988876
p_ni: 0.000011124
Score: 0.998
Data Source: BioPlex,STRINGDB
C16orf58
Tdark
Novelty: 0.34461652
p_int: 0.999584618
p_ni: 0.000414807
p_wrong: 5.74e-7
Score: 0.189
Data Source: BioPlex,STRINGDB
ADGRG5
Tdark
Family: GPCR
Novelty: 0.26575982
p_int: 0.998203905
p_ni: 0.001780833
p_wrong: 0.000015262
Score: 0.159
Data Source: BioPlex,STRINGDB
EFNA5
Tbio
Novelty: 0.00134985
Score: 0.997
Data Source: STRINGDB
EFNB3
Tbio
Novelty: 0.0120367
Score: 0.995
Data Source: STRINGDB
EFNB1
Tbio
Novelty: 0.00523161
Score: 0.995
Data Source: STRINGDB
EFNA3
Tbio
Novelty: 0.01819539
Score: 0.993
Data Source: STRINGDB
EFNA2
Tbio
Novelty: 0.01184859
Score: 0.992
Data Source: STRINGDB
EFNA4
Tbio
Novelty: 0.03628159
Score: 0.992
Data Source: STRINGDB
EFNA1
Tbio
Family: Kinase
Novelty: 0.00732252
Score: 0.992
Data Source: STRINGDB
Publication Statistics
PubMed Score  128.37

PubMed score by year
PubTator Score  48.52

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer