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Tbio
RAD23B
UV excision repair protein RAD23 homolog B

Protein Summary
Description
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome. Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with CETN2 appears to stabilize XPC. May protect XPC from proteasomal degradation. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix suc ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358015
  • ENSP00000350708
  • ENSG00000119318
  • ENST00000416373
  • ENSP00000405623

Symbol
  • P58
  • HR23B
  • HHR23B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
co-expressed gene
0.97
protein domain
0.97
transcription factor binding site profile
0.94
kinase perturbation
0.93


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.26   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 428   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.26   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 428   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.4
12.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.4
12.3
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAD23 homolog B, nucleotide excision repair protein
VGNC:4843
473012
Macaque
RAD23 homolog B, nucleotide excision repair protein
711328
Mouse
MGI:105128
19359
Rat
RGD:1562958
298012
Dog
RAD23 homolog B, nucleotide excision repair protein
VGNC:45316
481656
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAD23 homolog B, nucleotide excision repair protein
Macaque
RAD23 homolog B, nucleotide excision repair protein
Mouse
Rat
Dog
RAD23 homolog B, nucleotide excision repair protein
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P54727-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (13)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
DNA Damage Recognition in GG-NER
Reactome
DNA Repair
Reactome
Deubiquitination
Reactome
Formation of Incision Complex in GG-NER
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
DNA Damage Recognition in GG-NER
DNA Repair
Deubiquitination
Formation of Incision Complex in GG-NER
Gene Ontology Terms (20)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (410)
1 – 10 of 410
XPC
Tbio
Novelty:  0.00775175
p_int:  0.999961609
p_ni:  0.000038391
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
UBL7
Tdark
Novelty:  0.20935024
p_int:  0.999809485
p_ni:  0.000190515
Score:  0.853
Data Source:  BioPlex,STRINGDB
USP25
Tchem
Family:  Enzyme
Novelty:  0.03671706
p_int:  0.999279743
p_ni:  0.000720257
Score:  0.873
Data Source:  BioPlex,STRINGDB
UBE4B
Tbio
Novelty:  0.01396546
p_int:  0.989634546
p_ni:  0.010153704
p_wrong:  0.000211749
Score:  0.978
Data Source:  BioPlex,STRINGDB
KCTD10
Tbio
Novelty:  0.10573929
p_int:  0.98663002
p_ni:  0.01336998
Score:  0.413
Data Source:  BioPlex,STRINGDB
KCTD3
Tdark
Novelty:  0.33599775
p_int:  0.979087074
p_ni:  0.020912926
Score:  0.182
Data Source:  BioPlex,STRINGDB
BTBD9
Tbio
Novelty:  0.02793632
p_int:  0.963404675
p_ni:  0.036595325
Score:  0.669
Data Source:  BioPlex,STRINGDB
DDI2
Tbio
Novelty:  0.09288646
p_int:  0.924527457
p_ni:  0.075472543
Score:  0.656
Data Source:  BioPlex,STRINGDB
NGLY1
Tbio
Family:  Enzyme
Novelty:  0.01017395
p_int:  0.850811284
p_ni:  0.149188716
Score:  0.993
Data Source:  BioPlex,STRINGDB
UBB
Tbio
Novelty:  0.00661254
Score:  0.994
Data Source:  STRINGDB
Publication Statistics
PubMed Score  142.26

PubMed score by year
PubTator Score  66.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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