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Tbio
RAD23A
UV excision repair protein RAD23 homolog A

Protein Summary
Description
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC. (Microbial infection) Involved in Vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 Vpr with the host proteasome. The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair. Proteins in this family have a modular do ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316856
  • ENSP00000321365
  • ENSG00000179262
  • ENST00000586534
  • ENSP00000467024
  • ENST00000592268
  • ENSP00000468674

Symbol
  • HR23A
  • HHR23A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
protein domain
0.97
kinase perturbation
0.88
cell type or tissue
0.86
disease perturbation
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.73   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 450   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.73   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 450   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (34)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
3
6
6
98.2
reticulocyte measurement
3
4
5
97.2
mean corpuscular hemoglobin concentration
3
3
3
97
erythrocyte count
3
5
5
96.7
reticulocyte count
7
4
8
96.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
6
98.2
reticulocyte measurement
5
97.2
mean corpuscular hemoglobin concentration
3
97
erythrocyte count
5
96.7
reticulocyte count
8
96.5
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAD23 homolog A, nucleotide excision repair protein
VGNC:2275
100608041
Macaque
RAD23 homolog A, nucleotide excision repair protein
717979
Mouse
MGI:105126
19358
Rat
RGD:1309899
361381
Dog
RAD23 homolog A, nucleotide excision repair protein
VGNC:45315
484922
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAD23 homolog A, nucleotide excision repair protein
Macaque
RAD23 homolog A, nucleotide excision repair protein
Mouse
Rat
Dog
RAD23 homolog A, nucleotide excision repair protein
Protein Structure (11 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P54725-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (11)
DNA Damage Recognition in GG-NER (R-HSA-5696394)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Damage Recognition in GG-NER
Reactome
DNA Repair
Reactome
Deubiquitination
Reactome
Formation of Incision Complex in GG-NER
Reactome
Global Genome Nucleotide Excision Repair (GG-NER)
Name
Explore in Pharos
Explore in Source
DNA Damage Recognition in GG-NER
DNA Repair
Deubiquitination
Formation of Incision Complex in GG-NER
Global Genome Nucleotide Excision Repair (GG-NER)
Gene Ontology Terms (24)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (345)
1 – 10 of 345
CLDN19
Tbio
Novelty:  0.02391772
p_int:  0.802292935
p_ni:  0.197707065
Data Source:  BioPlex
UBC
Tbio
Novelty:  0.00204643
Score:  0.998
Data Source:  STRINGDB
UBA52
Tbio
Novelty:  0.01637744
Score:  0.998
Data Source:  STRINGDB
XPC
Tbio
Novelty:  0.00775175
Score:  0.997
Data Source:  STRINGDB
UBB
Tbio
Novelty:  0.00661254
Score:  0.996
Data Source:  STRINGDB
PSMD4
Tbio
Family:  Enzyme
Novelty:  0.00614538
Score:  0.994
Data Source:  STRINGDB
ATXN3
Tbio
Novelty:  0.00201109
Score:  0.989
Data Source:  Reactome,STRINGDB
RPS27A
Tbio
Novelty:  0.00658124
Score:  0.984
Data Source:  STRINGDB
XPA
Tchem
Novelty:  0.00137698
Score:  0.984
Data Source:  STRINGDB
CETN2
Tbio
Novelty:  0.00641301
Score:  0.967
Data Source:  STRINGDB
Publication Statistics
PubMed Score  57.73

PubMed score by year
PubTator Score  44.15

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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